Mast cells and mastocytosis

Metcalfe, Dean D.

doi:10.1182/blood-2007-11-078097

Cited by 536Mast cells and histamineGastrointestinal Tumor Research and TreatmentPlatelet Disorders and Treatments

Mast cells and mastocytosis

Open access

Metcalfe, Dean D.·2008·Blood

DOI 10.1182/blood-2007-11-078097PMC PMC2515131

Open this paper in CoChat — free account Open PDF

Abstract

Mast cells have been recognized for well over 100 years. With time, human mast cells have been documented to originate from CD34+ cells, and have been implicated in host responses in both innate and acquired immunity. In clinical immunology, they are recognized for their central role in IgE-mediated degranulation and allergic inflammation by virtue of their expression of the high-affinity receptor for IgE and release of potent proinflammatory mediators. In hematology, the clinical disease of mastocytosis is characterized by a pathologic increase of mast cells in tissues, often associated with mutations in KIT, the receptor for stem cell factor. More recently, and with increased understanding of how human mast cells are activated through receptors including the high-affinity receptor for IgE and KIT, specific tyrosine kinase inhibitors have been identified with the potential to interrupt signaling pathways and thus limit the proliferation of mast cells as well as their activation through immunoglobulin receptors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2007-11-078097

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The severity of MCA correlates with the extent of mediator release from MC during an anaphylactic reaction.
“the severity of MCA correlates with the extent of mediator release from MC during an anaphylactic reaction.”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [2]
The ‘Mast cells in inflammation’ section identifies mast cells as central to anaphylaxis, and ‘Human mast cell mediators’ describes the mediators they release. Neither section states that the severity of mast-cell activation correlates with the extent of mediator release during an anaphylactic reaction; searches for severity and correlation did not find that relationship. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Well-recognized symptoms of systemic MCA include acute urticaria, flushing, abdominal cramping, diarrhea, hypotensive syncope or near syncope, and tachycardia.
“Well-recognized symptoms of systemic MCA include, among others, acute urticaria, flushing, abdominal cramping, diarrhea, hypotensive syncope or near syncope and tachycardia (Table 3) (1-3,26-28,31).”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [2]
The section on diseases of abnormal mast-cell proliferation describes flushing, diarrhea, abdominal pain, and vascular instability as clinical features of mastocytosis. It does not specifically identify acute urticaria, abdominal cramping, hypotensive syncope or near syncope, or tachycardia as symptoms of systemic mast-cell activation; its discussion concerns mastocytosis rather than systemic MCA generally. No page number is available for the passage in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
MCA symptoms are caused by vasoactive and pro-inflammatory mediators released from MC upon activation by allergen via IgER cross-linking or other mechanisms.
“MCA symptoms are caused by several different vasoactive and pro-inflammatory mediators released from MC when these cells are activated by an allergen via IgER cross-linking or other mechanisms (1-5,29-31).”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [2]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues
Hossfeld, D. K. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf146 · Cited by 4,633 · see citing works
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., & Paul, W. E. (1989) · Nature · doi:10.1038/339064a0 · Cited by 1,170 · see citing works
The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus
Huang, E. J., Nocka, K. H., Beier, D. R., Chu, T.-Y., Buck, J., Lahm, H., Wellner, D., Leder, P., & Besmer, P. (1990) · Cell · doi:10.1016/0092-8674(90)90303-v · Cited by 1,149 · see citing works
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Murphy, R. C., Hammarström, S., & Samuelsson, B. O. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4275 · Cited by 998 · see citing works
Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
Gordon, J., & Galli, S. J. (1990) · Nature · doi:10.1038/346274a0 · Cited by 989 · see citing works
Critical protective role of mast cells in a model of acute septic peritonitis
Echtenacher, B., Männel, D. N., & Hültner, L. (1996) · Nature · doi:10.1038/381075a0 · Cited by 925 · see citing works
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.
Nagata, H., Worobec, A. S., Oh, C. K., Chowdhury, B. A., Tannenbaum, S. H., Suzuki, Y., & Metcalfe, D. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10560 · Cited by 871 · see citing works
Self-citation
Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
Anderson, D. M., Lyman, S. D., Baird, A. M., Wignall, J. M., Eisenman, J. R., Rauch, C. T., March, C. J., Boswell, H. S., Gimpel, S. D., Cosman, D. J., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90304-w · Cited by 827 · see citing works
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
Furitsu, T., Tsujimura, T., Tono, T., Ikeda, H., Kitayama, H., Koshimizu, U., Sugahara, H., Butterfield, J. H., Ashman, L. K., & Kanayama, Y. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116761 · Cited by 814 · see citing works
Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium
Zsebo, K. M., Wypych, J., McNiece, I., Lu, H. S., Smith, K. A., Karkare, S. B., Sachdev, R. K., Yuschenkoff, V. N., Birkett, N. C., Williams, L. R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90300-4 · Cited by 786 · see citing works
Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria
Valent, P., Akin, C., Escribano, L., Födinger, M., Hartmann, K., Brockow, K., Castells, M., Sperr, W. R., Kluin‐Nelemans, H. C., Hamdy, N. A. T., et al. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01807.x · Cited by 750 · see citing works
Self-citation
Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity
Ihle, J. N., Keller, J. R., Henderson, L. E. O., et al. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.5.2609.c · Cited by 689 · see citing works
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
Besmer, P., Murphy, J. E., George, P. C., et al. (1986) · Nature · doi:10.1038/320415a0 · Cited by 645 · see citing works
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm
Longley, B. J., Tyrrell, L., Lu, S.-Z., Ma, Y., Langley, K., Ding, T.-G., Duffy, T. P., Jacobs, P., Tang, L. H., & Modlin, I. M. (1996) · Nature Genetics · doi:10.1038/ng0396-312 · Cited by 606 · see citing works
Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin
Soter, N. A., Lewis, R. A., Corey, E. J., & Austen, K. F. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12531738 · Cited by 589 · see citing works
Complete structure and expression in transfected cells of high affinity IgE receptor
Blank, U., Ra, C., Miller, L., White, K., Metzger, H. P., & Kinet, J. (1989) · Nature · doi:10.1038/337187a0 · Cited by 521 · see citing works
Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity.
Ihle, J. N., Keller, J. R., Oroszlan, S., et al. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.1.282 · Cited by 506 · see citing works
Immunological studies of an atypical (myeloma) immunoglobulin.
Johansson, S. G. O., & Bennich, H. (1967) · PubMed · Cited by 473 · see citing works
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
Parravicini, V., Gadina, M., Kovářová, M., Odom, S., González‐Espinosa, C., Furumoto, Y., Saitoh, S.-I., Samelson, L. E., O’Shea, J. J., & Rivera, J. (2002) · Nature Immunology · doi:10.1038/ni817 · Cited by 449 · see citing works
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
Ma, Y., Zeng, S., Metcalfe, D. D., Akin, C., Dimitrijević, S., Butterfield, J. H., McMahon, G., & Longley, B. J. (2002) · Blood · doi:10.1182/blood.v99.5.1741 · Cited by 446 · see citing works
Self-citation
Mast cell tryptases and chymases in inflammation and host defense.
Caughey, G. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00509.x · Cited by 442 · see citing works
Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell Factor/kit-ligand in long-term culture
Valent, P., Spanblochl, E., Sperr, W., Sillaber, C., Zsebo, K., Agis, H., Strobl, H., Geissler, K., Bettelheim, P., & Lechner, K. (1992) · Blood · doi:10.1182/blood.v80.9.2237.2237 · Cited by 439 · see citing works
Physicochemical properties of reaginic antibody. V. Correlation of reaginic activity wth gamma-E-globulin antibody.
Ishizaka, K., Ishizaka, T., & Hornbrook, M. M. (1966) · PubMed · Cited by 425 · see citing works
Demonstration That Human Mast Cells Arise From a Progenitor Cell Population That Is CD34+, c-kit+, and Expresses Aminopeptidase N (CD13)
Kirshenbaum, A. S., Goff, J. P., Semere, T., Foster, B. A., Scott, L. M., & Metcalfe, D. D. (1999) · Blood · doi:10.1182/blood.v94.7.2333.419k30_2333_2342 · Cited by 420 · see citing works
Self-citation
Bronchoconstrictor Effects of Leukotriene C in Humans
Weiss, J. W., Drazen, J. M., Coles, N. A., et al. (1982) · Science · doi:10.1126/science.7063880 · Cited by 409 · see citing works
Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells
Kirshenbaum, A. S., Kessler, S., Goff, J. P., & Metcalfe, D. D. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.5.1410 · Cited by 361 · see citing works
Self-citation
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
Akin, C., Fumo, G., Yavuz, A. S., Lipsky, P. E., Neckers, L., & Metcalfe, D. D. (2003) · Blood · doi:10.1182/blood-2003-11-3816 · Cited by 359 · see citing works
Self-citation
Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3
Kulka, M., Alexopoulou, L., Flavell, R. A., & Metcalfe, D. D. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.049 · Cited by 354 · see citing works
Self-citation
Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.
Schwartz, L. B., & Bradford, T. R. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38401-6 · Cited by 348 · see citing works
Classification and Diagnosis of Mastocytosis: Current Status
Metcalfe, D. D. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12468882 · Cited by 348 · see citing works
Self-citation
Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells
Nabel, G. J., Galli, S. J., Dvořàk, A. M., Dvorak, H. F., & Cantor, H. (1981) · Nature · doi:10.1038/291332a0 · Cited by 340 · see citing works
Physicochemical Properties of Reaginic Antibody
Ishizaka, K., Ishizaka, T., & Hornbrook, M. M. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.97.6.840 · Cited by 334 · see citing works
Development of mast cells from grafted bone marrow cells in irradiated mice
Kitamura, Y., Shimada, M., Hatanaka, K., & MIYANO, Y. (1977) · Nature · doi:10.1038/268442a0 · Cited by 305 · see citing works
The mast cell and allergic diseases: role in pathogenesis and implications for therapy
Brown, J. M., Wilson, T. M., & Metcalfe, D. D. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02886.x · Cited by 289 · see citing works
Self-citation
Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells
Kirshenbaum, A. S., Goff, J. P., Kessler, S., Mican, J. M., Zsebo, K. M., & Metcalfe, D. D. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.772 · Cited by 284 · see citing works
Self-citation
The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.
Galli, S. J., Tsai, M. M., & Wershil, B. K. (1993) · PubMed · Cited by 278 · see citing works
Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement
Paolini, R., Jouvin, M., & Kinet, J. (1991) · Nature · doi:10.1038/353855a0 · Cited by 269 · see citing works
Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
Longley, B. J., Morganroth, G. S., Tyrrell, L., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305063281803 · Cited by 266 · see citing works
IgE receptors on human basophils. Relationship to serum IgE concentration.
Malveaux, F. J., Conroy, M. C., Adkinson, N. F., & Lichtenstein, L. M. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109103 · Cited by 264 · see citing works
Indolent Systemic Mast Cell Disease in Adults: Immunophenotypic Characterization of Bone Marrow Mast Cells and Its Diagnostic Implications
Escribano, L., Órfão, A., Dı́az-Agustı́n, B., Villarrubia, J., Cerveró, C. J., López, A., Marcos, M. A. G., Bellas, C., FERNANDEZCANADAS, S., Cuevas, M., et al. (1998) · Blood · doi:10.1182/blood.v91.8.2731.2731_2731_2736 · Cited by 250 · see citing works
Imatinib for systemic mast-cell disease
Pardanani, A. D., Elliott, M. A., Reeder, T. L., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14115-3 · Cited by 248 · see citing works
Cladribine therapy for systemic mastocytosis
Kluin‐Nelemans, H. C. (2003) · Blood · doi:10.1182/blood-2003-05-1699 · Cited by 246 · see citing works
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
Gotlib, J. R. (2005) · Blood · doi:10.1182/blood-2005-04-1568 · Cited by 242 · see citing works
Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria
Valent, P. (2003) · Leukemia Research · doi:10.1016/s0145-2126(02)00168-6 · Cited by 233 · see citing works
Response to Interferon Alfa-2b in a Patient with Systemic Mastocytosis
Kluin‐Nelemans, H. C., Jansen, J. H., Breukelman, H., Wolthers, B. G., Kluin, P. M., Kroon, H. M. J. A., & Willemze, R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202273260907 · Cited by 231 · see citing works
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.
Benhamou, M., Gutkind, J. S., Robbins, K. C., et al. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5327 · Cited by 229 · see citing works
Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
Akin, C., Brockow, K., D’Ambrosio, C., Kirshenbaum, A. S., Ma, Y., Longley, B. J., & Metcalfe, D. D. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00112-7 · Cited by 225 · see citing works
Self-citation
Interleukin-3 is a differentiation factor for human basophils
Valent, P., Schmidt, G., Besemer, J., Mayer, P., Zenke, G., Liehl, E., Hinterberger, W., Lechner, K., Maurer, D., & Bettelheim, P. (1989) · Blood · doi:10.1182/blood.v73.7.1763.1763 · Cited by 219 · see citing works
T Helper Cell Type 2 Cytokines Coordinately Regulate Immunoglobulin E–Dependent Cysteinyl Leukotriene Production by Human Cord Blood–Derived Mast Cells
Hsieh, F. H., LAM, B. K., Penrose, J. F., Austen, K. F., & Boyce, J. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.1.123 · Cited by 217 · see citing works
Human mast cells express functional TrkA and are a source of nerve growth factor
Nilsson, G. P., Forsberg‐Nilsson, K., Xiang, Z., Hallböök, F., Nilsson, K., & Metcalfe, D. D. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270925 · Cited by 210 · see citing works
Self-citation
Expression of a Functional High-Affinity IgG Receptor, FcγRI, on Human Mast Cells: Up-Regulation by IFN-γ
Okayama, Y., Kirshenbaum, A. S., & Metcalfe, D. D. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4332 · Cited by 205 · see citing works
Self-citation
Molecular cloning and sequence analysis of a chondroitin sulfate proteoglycan cDNA.
Bourdon, M. A., Oldberg, Å., Pierschbacher, M. D., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.5.1321 · Cited by 203 · see citing works
Expression of High-affinity Binding of Human Immunoglobulin E by Transfected Cells
Miller, L. R., Blank, U., Metzger, H., & Kinet, J. (1989) · Science · doi:10.1126/science.2523561 · Cited by 196 · see citing works
Mastocytosis: Pathology, genetics, and current options for therapy
Valent, P., Akin, C., Sperr, W. R., Mayerhofer, M., Födinger, M., Fritsche‐Polanz, R., Sotlar, K., Escribano, L., Arock, M., Horny, H., et al. (2004) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190400010775 · Cited by 195 · see citing works
Self-citation
Human mast cells are capable of serotonin synthesis and release
Kushnir‐Sukhov, N. M., Brown, J. M., Wu, Y., Kirshenbaum, A. S., & Metcalfe, D. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.09.003 · Cited by 194 · see citing works
Self-citation
A Case of Intestinal Mastocytosis Misdiagnosed as Crohn's Disease
Reggiani, S., Cosso, L., Adriani, A., Pantaleoni, S., Risso, A., Vittone, F., Chiusa, L., Sapone, N., & Astegiano, M. (2015) · Case Reports in Gastroenterology · doi:10.1159/000430946 · Cited by 193 · see citing works
Isolation of “biologically intact” mast cells
Uvnäs, B., & Thon, I. (1959) · Experimental Cell Research · doi:10.1016/0014-4827(59)90316-7 · Cited by 185 · see citing works
Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
Nigrovic, P. A., Binstadt, B. A., Monach, P. A., Johnsen, A. K., Gurish, M. F., Iwakura, Y., Benoist, C. O., Mathis, D. J., & Lee, D. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610852103 · Cited by 180 · see citing works
CD25 Indicates the Neoplastic Phenotype of Mast Cells
Sotlar, K., Horny, H., Simonitsch, I., Krokowski, M., Aichberger, K. J., Mayerhofer, M., Printz, D., Fritsch, G., & Valent, P. (2004) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000138181.89743.7b · Cited by 173 · see citing works
Mast Cell Survival and Activation by IgE in the Absence of Antigen: A Consideration of the Biologic Mechanisms and Relevance
Kawakami, T., & Kitaura, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4167 · Cited by 167 · see citing works
Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16
Rumsaeng, V., Cruikshank, W. W., Foster, B. A., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.2904 · Cited by 161 · see citing works
Treatment of Systemic Mast-Cell Disease with Cladribine
Tefferi, A., Li, C., Butterfield, J. H., & Hoagland, H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101253440415 · Cited by 160 · see citing works
Mast Cell Leukemia: Report of a Case and Review of the Literature
Travis, W. D., Li, C., Hoagland, H. C., Travis, L. B., & BANKS, P. M. (1986) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62636-6 · Cited by 159 · see citing works
Hematologic manifestations of systemic mast cell disease: A prospective study of laboratory and morphologic features and their relation to prognosis
Lawrence, J. B., Friedman, B. S., Travis, W. D., Chinchilli, V. M., Metcalfe, D. D., & Gralnick, H. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90214-i · Cited by 157 · see citing works
Self-citation
The Capacity of Human Immunoglobulin E to Mediate the Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung
Ishizaka, T., Ishizaka, K., Orange, R. P., et al. (1970) · The Journal of Immunology · doi:10.4049/jimmunol.104.2.335 · Cited by 155 · see citing works
Isolation and Characterization of Heparin from Human Lung
Metcalfe, D. D., Lewis, R. A., Silbert, J. E., ROSENBERG, R. D., Wasserman, S. I., & Austen, K. F. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109613 · Cited by 155 · see citing works
Self-citation
The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells
Maurer, M., Echtenacher, B., Hültner, L., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2343 · Cited by 150 · see citing works
Histamine in Tissue Mast Cells
RILEY, J. F. (1953) · Science · doi:10.1126/science.118.3064.332 · Cited by 149 · see citing works
Urticaria pigmentosa; a report of a case with autopsy.
Jm, E. (1949) · PubMed · Cited by 149 · see citing works
TREATMENT OF SYSTEMIC MAST CELL DISORDERS
Worobec, A. S. (2000) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70301-4 · Cited by 136 · see citing works
The biology of Kit in disease and the application of pharmacogenetics
Akin, C., & Metcalfe, D. D. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.04.046 · Cited by 131 · see citing works
Self-citation
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc RI aggregation
Tkaczyk, C. (2004) · Blood · doi:10.1182/blood-2003-08-2769 · Cited by 130 · see citing works
Frequency and characterization of antigen-specific IL-4– and IL-13– producing basophils and T cells in peripheral blood of healthy and asthmatic subjects
Devouassoux, G., Foster, B. A., Scott, L. M., et al. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70292-7 · Cited by 122 · see citing works
KIT D816V–associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities
Marić, I., Robyn, J. A., Metcalfe, D. D., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.05.024 · Cited by 112 · see citing works
Self-citation
A Comparison of Mediators Released or Generated by IFN-γ-Treated Human Mast Cells Following Aggregation of FcγRI or FcεRI
Okayama, Y., Hagaman, D. D., & Metcalfe, D. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4705 · Cited by 109 · see citing works
Self-citation
Rare forms of urticaria
Nettleship, E. (1869) · Medical Entomology and Zoology · Cited by 105 · see citing works
IL-3-dependent growth of basophil-like cells and mastlike cells from human bone marrow.
Kirshenbaum, A. S., Goff, J. P., Dreskin, S. C., et al. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.7.2424 · Cited by 104 · see citing works
Silica-Directed Mast Cell Activation Is Enhanced by Scavenger Receptors
Brown, J. M., Swindle, E. J., Kushnir‐Sukhov, N. M., Holian, A., & Metcalfe, D. D. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0197oc · Cited by 100 · see citing works
Self-citation
ANTIGEN-INDUCED RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-ARAT) IN RATS PREPARED WITH HOMOLOGOUS ANTIBODY
Orange, R. P., Valentine, M. D., & Austen, K. F. (1968) · The Journal of Experimental Medicine · doi:10.1084/jem.127.4.767 · Cited by 95 · see citing works
Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines.
Ehrenreich, H., Burd, P. R., Rottem, M., Hültner, L., Hylton, J. B., Garfield, M. K., Coligan, J. E., Metcalfe, D. D., & Fauci, A. S. (1992) · PubMed · Cited by 83 · see citing works
Self-citation
Lysophosphatidic acid accelerates the development of human mast cells
Bagga, S., Price, K. S., Lin, D. A., et al. (2004) · Blood · doi:10.1182/blood-2004-03-1166 · Cited by 80 · see citing works
Occurrence of Heparin in the Invertebrate Styela plicata (Tunicata) Is Restricted to Cell Layers Facing the Outside Environment
Cavalcante, M. C. M., Allodi, S., Valente, A. P., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005830200 · Cited by 75 · see citing works
Cutting Edge: Interleukin 4-Dependent Mast Cell Proliferation Requires Autocrine/Intracrine Cysteinyl Leukotriene-Induced Signaling
Jiang, Y., Kanaoka, Y., Feng, C., Nocka, K. H., Rao, S. S., & Boyce, J. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2755 · Cited by 64 · see citing works
A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis
Nakamura, R., Chakrabarti, S., Akin, C., et al. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705245 · Cited by 63 · see citing works
Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA.
Avraham, S., Stevens, R. L., Nicodemus, C. F., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3763 · Cited by 62 · see citing works
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: Correlation with dermal mast-cell numbers and mast-cell tryptase
Brockow, K., Akin, C., Huber, M., Scott, L. M., Schwartz, L. B., & Metcalfe, D. D. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.120524 · Cited by 61 · see citing works
Self-citation
Polydispersity of rat mast cell heparin. Implications for proteoglycan assembly.
Metcalfe, D. D., Smith, J. A., Austen, K. F., et al. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70198-7 · Cited by 56 · see citing works
Self-citation
Peritoneal reactions in the white rat, with especial reference to the mast cells
Webb, R. L. (1931) · American Journal of Anatomy · doi:10.1002/aja.1000490206 · Cited by 53 · see citing works
Typical and atypical mast cells of the rat gastrointestinal system: Distribution and correlation with tissue histamine
Saavedra‐Delgado, A. M., Turpin, S., & Metcalfe, D. D. (1984) · Inflammation Research · doi:10.1007/bf01966825 · Cited by 53 · see citing works
Self-citation
On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts
Valent, P., Ghannadan, M., Akin, C., Krauth, M. T., Selzer, E., Mayerhofer, M., Sperr, W. R., Arock, M., Samorapoompichit, P., Horny, H. ‐., et al. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.0960-135x.2004.01369.x · Cited by 51 · see citing works
Self-citation
Association of the Q576R polymorphism in the interleukin-4 receptor α chain with indolent mastocytosis limited to the skin
Daley, T., Metcalfe, D. D., & Akin, C. (2001) · Blood · doi:10.1182/blood.v98.3.880 · Cited by 51 · see citing works
Self-citation
AN UNUSUAL CAUSE OF PAIN AND HAEMATURIA
Ellis, E. (1928) · BMJ · doi:10.1136/bmj.2.3528.323-d · Cited by 50 · see citing works
Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion
Lahortiga, I., Akin, C., Cools, J., et al. (2007) · Haematologica · doi:10.3324/haematol.11836 · Cited by 49 · see citing works
Inhibition of human mast cell growth and differentiation by interferon gamma-1b.
Kirshenbaum, A. S., Worobec, A. S., Davis, T. A., et al. (1998) · PubMed · Cited by 45 · see citing works
High-resolution tracking of cell division demonstrates differential effects of TH1 and TH2 cytokines on SCF-dependent human mast cell production in vitro:correlation with apoptosis and Kit expression
Kulka, M., & Metcalfe, D. D. (2004) · Blood · doi:10.1182/blood-2004-07-2838 · Cited by 45 · see citing works
Self-citation
Mast cells in cutaneous mastocytosis: accumulation of the MCTC type
Irani, A.-M. A., Garriga, M. M., Metcalfe, D. D., & Schwartz, L. B. (1990) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1990.tb02775.x · Cited by 44 · see citing works
Self-citation
ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG
Austen, K. F., & Brocklehurst, W. E. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.113.3.541 · Cited by 43 · see citing works
Heparin: Its Chemistry, Physiology and Application in Medicine
(1940) · JAMA · doi:10.1001/jama.1940.02810040060034 · Cited by 42 · see citing works
Splenectomy in the management of systemic mast cell disease.
Friedman, B. S., Darling, G. E., Norton, J., et al. (1990) · PubMed · Cited by 41 · see citing works
Oxidative degradation of rat mast-cell heparin proteoglycan
Metcalfe, D. D., Thompson, H. L., Klebanoff, S. J., & Henderson, W. R. (1990) · Biochemical Journal · doi:10.1042/bj2720051 · Cited by 34 · see citing works
Self-citation
Human gastric mucosal mast cells are chondroitin sulphate E-containing mast cells.
GILEAD, L. T., Livni, N., Eliakim, R., et al. (1987) · PubMed · Cited by 32 · see citing works
IN VITRO PASSIVE SENSITIZATION OF CHOPPED GUINEA PIG LUNG BY GUINEA PIG 7S ANTIBODIES.
Ar, B., Bloch, K. J., & Kf, A. (1964) · PubMed · Cited by 31 · see citing works
Secretion of Interleukin-1 Receptor Antagonist from Human Mast Cells after Immunoglobulin E–Mediated Activation and after Segmental Antigen Challenge
Hagaman, D. D., Okayama, Y., D’Ambrosio, C., Prussin, C., Gilfillan, A. M., & Metcalfe, D. D. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.6.4541 · Cited by 24 · see citing works
Self-citation
Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen‐specific ige and parenteral challenge with specific antigen
Malone, D. G., & Metcalfe, D. D. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310820 · Cited by 23 · see citing works
Self-citation
Inefficacy of imatinib-mesylate in sporadic, aggressive systemic mastocytosis
Musto, P., Falcone, A. P., Sanpaolo, G., et al. (2003) · Leukemia Research · doi:10.1016/j.leukres.2003.09.001 · Cited by 22 · see citing works
Cytogenetic abnormalities and their lack of relationship to the Asp816Val c-kit mutation in the pathogenesis of mastocytosis
Worobec, A. S., Akin, C., Scott, L. M., et al. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70144-7 · Cited by 21 · see citing works
In Vitro Passive Sensitization of Chopped Guinea Pig Lung by Guinea Pig 7S Antibodies
Baker, A. R., Bloch, K. J., & Austen, K. F. (1964) · The Journal of Immunology · doi:10.4049/jimmunol.93.4.525 · Cited by 21 · see citing works
Thrombopoietin alone or in the presence of stem cell factor supports the growth of KIT(CD117)low/ MPL(CD110)+ human mast cells from hematopoietic progenitor cells
Kirshenbaum, A. S., Akin, C., Goff, J. P., et al. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.12.005 · Cited by 20 · see citing works
The mast cell and allergic diseases: role in pathogenesis and implications for therapy
Edwards, A. M. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03000.x · Cited by 19 · see citing works
Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. J. Immunol. 1966. 97: 840–853
Ishizaka, K., Ishizaka, T., & Hornbrook, M. M. (2017) · The Journal of Immunology · doi:10.1093/jimmunol/198.1.16 · Cited by 6 · see citing works
[Mastocytosis].
DEGOS, R. (2003) · PubMed · Cited by 3 · see citing works
Untitled work
(1998) · doi:10.1002/(sici)1096-8652(199801)57:1

Flagged first, then by citations

Research works printed but not linked: 14

[5]5. Ehrlich P. Beitrage zur theorie und praxis der his- tologischen fa ¨rbung [thesis]. Leipzig, Germany: University of Leipzig; 1878.
[6]6. Unna PG. Die spezifische fa ¨rbung der mastzel- lenko ¨rnung. Monatsh Prakt Dermatol. 1894;19: 367-368.
[15]15. Sangster A. An anomalous mottled rash, accom- panied by pruritus, factitious urticaria and pig- mentation, "urticaria pigmentosa?" Trans Clin Soc London. 1878;11:161-163.
[17]17. Degos R. Les mastocytoses. Bull Soc Med Ho ˆp (Paris). 1956;72:111-121.
[31]31. Iran A-MA, Garriga MM, Metcalfe DD, Schwartz LB. Mast cells in cutaneous mastocystosis: accu- mulation of the MC TC type. Clin Exp Allergy. 1990;20:53-58.
[39]39. Ehrenreich H, Burd PR, Rottem M, et al. Endo- thelins belong to the assortment of mast cell de- rived and mast cell associated cytokines. New Biologist. 1992;4:147-156.
[43]43. Hagaman DD, Okayama Y, Ambrosio CD, Gilfillan AM, Prussin C, Metcalfe DD. Secretion of inter- leukin-1 receptor antagonist from human mast cells following IgE mediated activation and follow- ing segmental antigen challenge. Am J Resp Cell Mol Biol. 2001;25:685-691.
[44]44. Devouassoux G, Foster B, Scott LM, Metcalfe DD, Prussin C. Frequency and characterization of antigen-specific IL-4 and IL-13 producing ba- sophils and T cells in peripheral blood of normals and asthmatics. J Allergy Clin Immunol. 1999; 104:811-819.
[48]48. Ihle JN, Keller J, Oroszlan S, et al. Biologic prop- erties of homogenous interleukin 3. J Immunol. 1983;131:282-287.
[49]49. Kirshenbaum AS, Goff JP, Irani A-M, Schwartz LB, Metcalfe DD. Interleukin 3-dependent growth of basophil-like cells and mast-like cells from hu- man bone marrow. J Immunol. 1989;83:595-601.
[50]50. Valent P, Schmidt G, Besemer J, et al. Interleu- kin-3 is a differentiation factor for human ba- sophils. Blood. 1989;73:1763-1769.
[66]66. Prausnitz C, Kustner H. Studien u ¨ber die Verber- empFindlichkeit. Z Bakt. 1921;86:160-163.
[75]75. Tkaczyk C, Horejsi V, Iwaki S, et al. NTAL phos- phorylation is a pivotal link between the signaling cascades leading to human mast cell degranula- tion following Kit activation and Fc␧R1 aggrega- tion. Blood. 2004;104:207-214.
[87]87. Akin C, Metcalfe DD. The biology of Kit in disease and the application of pharmacogenetics. J Al- lergy Clin Immunol. 2004;114:13-19.

Sorted by citations

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal
Valent, P., Akin, C., Arock, M., Brockow, K., Butterfield, J. H., Carter, M. C., Castells, M., Escribano, L., Hartmann, K., Lieberman, P., et al. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000328760 · Cited by 654 · see citing works
Self-citation
Anaphylaxis—a practice parameter update 2015
Lieberman, P., Nicklas, R. A., Randolph, C., Oppenheimer, J., Bernstein, D., Bernstein, J., Ellis, A., Golden, D. B. K., Greenberger, P., Kemp, S., et al. (2015) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2015.07.019 · Cited by 474 · see citing works
Self-citation
Mast cell activation syndrome: Proposed diagnostic criteria
Akin, C., Valent, P., & Metcalfe, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.035 · Cited by 327 · see citing works
Self-citation
Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal
Valent, P., Akin, C., Hartmann, K., Alvarez-Twose, I., Brockow, K., Hermine, O., Niedoszytko, M., Schwaab, J., Lyons, J. J., Carter, M. C., et al. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000646 · Cited by 317 · see citing works
Self-citation
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis
Arock, M., Sotlar, K., Akin, C., Broesby-Olsen, S., Hoermann, G., Escribano, L., Kristensen, T. K., Kluin-Nelemans, H. C., Hermine, O., Dubreuil, P., et al. (2015) · Leukemia · doi:10.1038/leu.2015.24 · Cited by 290 · see citing works
Self-citation
Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome
Valent, P., Akin, C., Bonadonna, P., Hartmann, K., Brockow, K., Niedoszytko, M., Nedoszytko, B., Siebenhaar, F., Sperr, W. R., Oude Elberink, J. N. G., et al. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.01.006 · Cited by 220 · see citing works
“Severe or even life-threatening MCA may develop when (1) the burden of MCs is high, (2) when MCs are in a “hyperactivated” state, and (3) when comorbidities make the patient less tolerant to MCA events.”
BackgroundMethodInfluentialSelf-citation
Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis
Valent, P., Escribano, L., Broesby‐Olsen, S., Hartmann, K., Grattan, C., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, J. N. G., Kristensen, T., et al. (2014) · Allergy · doi:10.1111/all.12436 · Cited by 174 · see citing works
Self-citation
Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome
Valent, P., Bonadonna, P., Hartmann, K., Broesby-Olsen, S., Brockow, K., Butterfield, J. H., Triggiani, M., Lyons, J. J., Oude Elberink, J. N. G., Arock, M., et al. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000501079 · Cited by 146 · see citing works
Self-citation
The mastocytosis society survey on mast cell disorders: patient experiences and perceptions
Jennings, S., Russell, N., Jennings, B., Slee, V., Sterling, L., Castells, M., Valent, P., & Akin, C. (2014) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2013.09.004 · Cited by 143 · see citing works
Mast cell activation syndromes: definition and classification
Valent, P. (2013) · Allergy · doi:10.1111/all.12126 · Cited by 120 · see citing works
Omalizumab prevents anaphylaxis and improves symptoms in systemic mastocytosis: efficacy and safety observations
Broesby‐Olsen, S., Vestergaard, H., Mortz, C. G., Jensen, B., Havelund, T., Hermann, A. P., Siebenhaar, F., Møller, M. B., Kristensen, T. K., Bindslev‐Jensen, C., et al. (2018) · Allergy · doi:10.1111/all.13237 · Cited by 112 · see citing works
Mast Cells Are Critical Regulators of Bone Fracture–Induced Inflammation and Osteoclast Formation and Activity
Kroner, J., Kovtun, A., Kemmler, J., Messmann, J. J., Strauss, G., Seitz, S., Schinke, T., Amling, M., Kotrba, J., Froebel, J., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3234 · Cited by 95 · see citing works
Global classification of mast cell activation disorders: an ICD-10-CM–adjusted proposal of the ECNM-AIM Consortium
Valent, P., Hartmann, K., Bonadonna, P., Gülen, T., Brockow, K., Alvarez-Twose, I., Hermine, O., Niedoszytko, M., Carter, M. C., Hoermann, G., et al. (2022) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2022.05.007 · Cited by 90 · see citing works
Self-citation
Mast Cells in Allergic and Inflammatory Diseases
Sismanopoulos, N., Delivanis, D.-A., Alysandratos, K.-D., Angelidou, A., Therianou, A., Kalogeromitros, D., & C. Theoharides, T. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212800165997 · Cited by 87 · see citing works
Digital PCR: A Sensitive and Precise Method for KIT D816V Quantification in Mastocytosis
Greiner, G., Gurbisz, M., Ratzinger, F., Witzeneder, N., Simonitsch-Klupp, I., Mitterbauer-Hohendanner, G., Mayerhofer, M., Müllauer, L., Sperr, W. R., Valent, P., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2017.277897 · Cited by 83 · see citing works
Mastocytosis: The puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease
Gülen, T., Hägglund, H., Dahlén, B., & Nilsson, G. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12410 · Cited by 75 · see citing works
Personalized management strategies in mast cell disorders: ECNM-AIM user’s guide for daily clinical practice
Valent, P., Hartmann, K., Schwaab, J., Alvarez-Twose, I., Brockow, K., Bonadonna, P., Hermine, O., Niedoszytko, M., Carter, M. C., Hoermann, G., et al. (2022) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2022.03.007 · Cited by 72 · see citing works
Self-citation
Omalizumab therapy for mast cell-mediator symptoms in patients with ISM, CM, MMAS, and MCAS
Lemal, R., Fouquet, G., Terriou, L., Vaes, M., Livideanu, C. B., Frenzel, L., Barete, S., Canioni, D., Lhermitte, L., Rossignol, J., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.03.039 · Cited by 70 · see citing works
Clinical relevance of inherited genetic differences in human tryptases
Glover, S. C., Carter, M. C., Korošec, P., Bonadonna, P., Schwartz, L. B., Milner, J. D., Caughey, G. H., Metcalfe, D. D., & Lyons, J. J. (2021) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2021.08.009 · Cited by 64 · see citing works
Self-citation
Mast cell activation disorders
Akin, C. (2014) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2014.03.007 · Cited by 56 · see citing works
Recognizing mastocytosis in patients with anaphylaxis: value of KIT D816V mutation analysis of peripheral blood
Broesby-Olsen, S., Oropeza, A. R., Bindslev-Jensen, C., Vestergaard, H., Møller, M. B., Siebenhaar, F., Kristensen, T., & Mortz, C. G. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.031 · Cited by 54 · see citing works
Massive release of the histamine‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients
Boehm, T., Reiter, B., Ristl, R., Petroczi, K., Sperr, W., Stimpfl, T., Valent, P., & Jilma, B. (2019) · Allergy · doi:10.1111/all.13663 · Cited by 53 · see citing works
Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond
Sprinzl, B., Greiner, G., Uyanik, G., Arock, M., Haferlach, T., Sperr, W. R., Valent, P., & Hoermann, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052458 · Cited by 51 · see citing works
Inherited and acquired determinants of serum tryptase levels in humans
Lyons, J. J. (2021) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2021.06.019 · Cited by 52 · see citing works
Mast cell mediators of significance in clinical practice in mastocytosis
Butterfield, J. H., Ravi, A., & Pongdee, T. (2018) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2018.04.011 · Cited by 48 · see citing works
Doctor, I think I am suffering from MCAS: differential diagnosis and separating facts from fiction
Valent, P., & Akin, C. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2018.11.045 · Cited by 47 · see citing works
Immunology and clinical manifestations of non-clonal mast cell activation syndrome
Cardet, J.-C., Castells, M. C., & Hamilton, M. J. (2013) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0326-8 · Cited by 39 · see citing works
Review and updates on systemic mastocytosis and related entities
Li, J. Y., Ryder, C. B., Zhang, H., Cockey, S. G., Hyjek, E., Moscinski, L. C., Sagatys, E., & Song, J. (2023) · Cancers · doi:10.3390/cancers15235626 · Cited by 31 · see citing works
Tryptase is not cleared by the kidneys into the urine
Simon, M. R., Jan, M., Yee, J., Nori, U. S., Hu, J., Akin, C., & Schwartz, L. B. (2010) · International Archives of Allergy and Immunology · doi:10.1159/000260080 · Cited by 21 · see citing works

Stem Cell Factor Has a Suppressive Activity to IgE-Mediated Chemotaxis of Mast Cells
Sawada, J., Shimizu, S., Tamatani, T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3626 · Cited by 29 · see citing works
Prevention of F ‐actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells
Smrž, D., Bandara, G., Beaven, M. A., Metcalfe, D. D., & Gilfillan, A. M. (2013) · European Journal of Immunology · doi:10.1002/eji.201243214 · Cited by 27 · see citing works
Self-citation
Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis
Smeets, T. J. M., Dolhain, R. J. E. M., Breedveld, F. C., & Tak, P. P. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199809)186:1 · Cited by 136 · see citing works
c-Kit and c-kit mutations in mastocytosis and other hematological diseases
Boissan, M., Féger, F., Guillosson, J., & Arock, M. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.2.135 · Cited by 123 · see citing works
The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function.
Wershil, B. K., Tsai, M. M., Geissler, E. N., Zsebo, K. M., & Galli, S. J. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.245 · Cited by 140 · see citing works

Authors: Metcalfe, D. D.
Affiliations: National Institutes of Health (US)
Corresponding author: Metcalfe, Dean D.
ORCID: Metcalfe, Dean D.
Venue: Blood
Publisher: American Society of Hematology
Published: 2008-08-15
Volume: 112
Issue: 4
Pages: 946-956
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2007-11-078097
PMC: PMC2515131
OpenAlex: W2012512942
Cited by: 536
References: 112
Citations by year: 2026: 9 · 2025: 14 · 2024: 18 · 2023: 21 · 2022: 23 · 2021: 33 · 2020: 27 · 2019: 33 · 2018: 29 · 2017: 39 · 2016: 17 · 2015: 35 · 2014: 55 · 2013: 42 · 2012: 41
FWCI: 2.46
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases
National Institutes of Health
National Institute of Allergy and Infectious Diseases
NHLBI Division of Intramural Research
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords: mast cells, mastocytosis, CD34+ cells, IgE receptor, KIT mutations, stem cell factor, mast cell degranulation, allergic inflammation, tyrosine kinase inhibitors, mast cell activation, innate and adaptive immunity
MeSH terms: Animals, Humans, Inflammation, Mast Cells, Mastocytosis, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mast cells and mastocytosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks