The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Carbohydrate Metabolism in Non-Insulin-Dependent Diabetes Mellitus
Abstract
DIABETES mellitus is characterized by both fasting hyperglycemia and exaggerated postprandial increases in the plasma glucose level. Understanding the causes of these abnormalities is important for the rational use of current treatments and for developing more effective therapy. In this seminar, we review the physiology of normal carbohydrate metabolism and the pathophysiology of abnormalities in diabetes mellitus.Normal Physiology: Postabsorptive StateThe term "postabsorptive state" refers to the period 6 to 12 hours after a meal during which the transition from the postprandial to the fasting state occurs. At this time plasma glucose levels are at a nearly steady state; . . .
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“The rise in plasma glucose concentration stimulates insulin secretion, which results in suppression of glucose release and stimulation of glucose uptake (12,31).”
From Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects (2004) · cites this paper as [12]
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Metadata
- Authors
- Dinneen, S., Gerich, J., & Rizza, R.
- Affiliations
- From the Department of Medicine, Mayo Clinic, Rochester, Minn. (S.D., R.R.), and the Department of Biochemistry, Whittier Institute for Diabetes and Endocrinology, La Jolla, Calif. (J.G.). Address reprint requests to Dr. Rizza at the Endocrine Research Unit, Rm. 5–164, W. Joseph Bldg., Mayo Clinic, Rochester, MN 55905.
- Mayo Clinic (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-09-03
- Volume
- 327
- Issue
- 10
- Pages
- 707-713
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2074366941
- Cited by
- 279
- References
- 59
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 13 · 2014: 12 · 2013: 6 · 2012: 14
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-20411, DK 29953)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- carbohydrate metabolism, type 2 diabetes, fasting hyperglycemia, postprandial hyperglycemia, postabsorptive state, plasma glucose regulation, diabetes pathophysiology
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Carbohydrate Metabolism
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