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Cited by 438

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

A Controlled Trial of Scheduled Replacement of Central Venous and Pulmonary-Artery Catheters

Open access
Cobb, David K., High, Kevin P., Sawyer, Robert G., Sable, Carole A., Adams, Reid B., Lindley, Dwight A., Pruett, Timothy L., Schwenzer, Karen J., Farr, Barry M.·1992·New England Journal of Medicine
DOI 10.1056/nejm199210083271505
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Abstract

BACKGROUND: The incidence of infection increases with the prolonged use of central vascular catheters, but it is unclear whether changing catheters every three days, as some recommend, will reduce the rate of infection, It is also unclear whether it is safer to change a catheter over a guide wire or insert it at a new site. METHODS: We conducted a controlled trial in adult patients in intensive care units who required central venous or pulmonary-artery catheters for more than three days. Patients were assigned randomly to undergo one of four methods of catheter exchange: replacement every three days either by insertion at a new site (group 1) or by exchange over a guide wire (group 2), or replacement when clinically indicated either by insertion at a new site (group 3) or by exchange over a guide wire (group 4). RESULTS: Of the 160 patients, 5 percent had catheter-related bloodstream infections, 16 percent had catheters that became colonized, and 9 percent had major mechanical complications. The incidence rates (per 1000 days of catheter use) of bloodstream infection were 3 in group 1, 6 in group 2, 2 in group 3, and 3 in group 4; the incidence rates of mechanical complications were 14, 4, 8, and 3, respectively. Patients randomly assigned to guide-wire-assisted exchange were more likely to have bloodstream infection after the first three days of catheterization (6 percent vs. 0, P = 0.06). Insertions at new sites were associated with more mechanical complications (5 percent vs. 1 percent, P = 0.005). CONCLUSIONS: Routine replacement of central vascular catheters every three days does not prevent infection. Exchanging catheters with the use of a guide wire increases the risk of bloodstream infection, but replacement involving insertion of catheters at new sites increases the risk of mechanical complications.

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Crossref · 10.1056/nejm199210083271505

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Metadata

Authors
Cobb, D. K., High, K. P., Sawyer, R. G., Sable, C. A., Adams, R. B., Lindley, D. A., Pruett, T. L., Schwenzer, K. J., & Farr, B. M.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1992-10-08
Volume
327
Issue
15
Pages
1062-1068
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199210083271505
OpenAlex
W2335979543
Cited by
438
References
22
FWCI
34.45
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A Controlled Trial of Scheduled Replacement of Central Venous and Pulmonary-Artery Catheters. https://app.cochat.ai/papers/10.1056/nejm199210083271505
The paper
Cobb, D. K., High, K. P., Sawyer, R. G., Sable, C. A., Adams, R. B., Lindley, D. A., Pruett, T. L., Schwenzer, K. J., & Farr, B. M. (1992). A Controlled Trial of Scheduled Replacement of Central Venous and Pulmonary-Artery Catheters. New England Journal of Medicine. https://doi.org/10.1056/nejm199210083271505

Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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