Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support
Open accessAbstract
BACKGROUND: Radiolabeled monoclonal antibodies recognizing B-lymphocyte surface antigens represent a potentially effective new therapy for lymphomas. We assessed the biodistribution, toxicity, and efficacy of anti-CD20 (B1 and 1F5) and anti-CD37 (MB-1) antibodies labeled with iodine-131 in 43 patients with B-cell lymphoma in relapse. METHODS: Sequential biodistribution studies were performed with escalating doses of antibody (0.5, 2.5, and 10 mg per kilogram of body weight) trace-labeled with 5 to 10 mCi of 131I. The doses of radiation absorbed by tumors and normal organs were estimated by serial gamma-camera imaging and tumor biopsies. Patients whose tumors were estimated to receive greater doses of radiation than the liver, lungs, or kidneys (i.e., patients with a favorable biodistribution) were eligible for therapeutic infusion of 131I-labeled antibodies according to a phase 1 dose-escalation protocol. RESULTS: Twenty-four patients had a favorable biodistribution, and 19 received therapeutic infusions of 234 to 777 mCi of 131I-labeled antibodies (58 to 1168 mg) followed by autologous marrow reinfusion, resulting in complete remission in 16, a partial response in 2, and a minor response (25 to 50 percent regression of tumor) in 1. Nine patients have remained in continuous complete remission for 3 to 53 months. Toxic effects included myelosuppression, nausea, infections, and two episodes of cardiopulmonary toxicity, and were moderate in patients treated with doses of 131I-labeled antibodies that delivered less than 27.25 Gy to normal organs. CONCLUSIONS: High-dose radioimmunotherapy with 131I-labeled antibodies is associated with a high response rate in patients with B-cell lymphoma in whom antibody biodistribution is favorable.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lister, T. A., Crowther, D., Sutcliffe, S. B., GLATSTEIN, E. J., Canellos, G. P., Young, R. C., Rosenberg, S. A., Coltman, C. A., & Tubiana, M. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.11.1630 · Cited by 1,628 · see citing works
Regimen-related toxicity in patients undergoing bone marrow transplantation.
Bearman, S. I., Appelbaum, F. R., Buckner, C. D., et al. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.10.1562 · Cited by 891 · see citing works
Self-citationRadioimmunotherapy of B-Cell Lymphoma with [131I]Anti-B1 (Anti-CD20) Antibody
Kaminski, M. S., Zasadny, K. R., Francis, I. R., Milik, A. W., Ross, C. W., Moon, S. D., Crawford, S. M., Burgess, J. M., Petry, N. A., Butchko, G. M., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308123290703 · Cited by 547 · see citing works
Self-citationTreatment of Non-Hodgkin's Lymphoma
Wood, A. J. J., & Armitage, J. O. (1993) · New England Journal of Medicine · doi:10.1056/nejm199304083281409 · Cited by 381 · see citing works
Monoclonal antibody 1F5 (anti-CD20) serotherapy of human B cell lymphomas
Press, O. W., Appelbaum, F. R., Ledbetter, J. A., Martin, P., Zarling, J. M., Kidd, P. G., & Thomas, E. D. (1987) · Blood · doi:10.1182/blood.v69.2.584.584 · Cited by 361 · see citing works
Self-citationTreatment of refractory non-Hodgkin's lymphoma with radiolabeled MB-1 (anti-CD37) antibody.
Press, O. W., Eary, J. F., Badger, C. C., et al. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.8.1027 · Cited by 276 · see citing works
Self-citationEndocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies.
Press, O. W., Farr, A. G., Borroz, K. I., Anderson, S. K., & Martin, P. J. (1989) · PubMed · Cited by 248 · see citing works
Self-citationAppelbaum, F. R., Sullivan, K. M., Buckner, C. D., Clift, R., Deeg, H. J., Fefer, A., Hill, R. S., Mortimer, J. E., NEIMAN, P. E., & Sanders, J. E. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.9.1340 · Cited by 233 · see citing works
Self-citationMonoclonal antibody-based therapies of leukemia and lymphoma
Grossbard, M., Press, O. W., Appelbaum, F., et al. (1992) · Blood · doi:10.1182/blood.v80.4.863.863 · Cited by 212 · see citing works
Self-citationGoldenberg, D. M., Horowitz, J. A., Sharkey, R. M., Hall, T. C., Murthy, S., Goldenberg, H., Lee, R. E., Stein, R., Siegel, J. A., & Izon, D. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.4.548 · Cited by 199 · see citing works
Freedman, A., Takvorian, T., Anderson, K., et al. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.5.784 · Cited by 165 · see citing works
Kaminski, M. S., Fig, L. M., Zasadny, K. R., Koral, K. F., Delrosario, R., Francis, I. R., Hanson, C. A., Normolle, D. P., Mudgett, E. E., & Liu, C. P. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.11.1696 · Cited by 152 · see citing works
Tumor size: effect on monoclonal antibody uptake in tumor models.
Hagan, P. L., Halpern, S. E., Dillman, R. O., et al. (1986) · PubMed · Cited by 134 · see citing works
Hantgan, R., Hindriks, G., Taylor, R., Sixma, J. J., & de Groot, P. G. (1990) · Blood · doi:10.1182/blood.v76.2.345.345 · Cited by 123 · see citing works
Vriesendorp, H. M., Herpst, J., Germack, M. A., Klein, J., Leichner, P. K., Loudenslager, D. M., & Order, S. E. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.6.918 · Cited by 119 · see citing works
Imaging and treatment of B-cell lymphoma.
Eary, J. F., Press, O. W., Badger, C. C., et al. (1990) · PubMed · Cited by 111 · see citing works
Self-citationThe Multichain Interleukin-2 Receptor: A Target for Immunotherapy
Waldmann, T. A., Pastan, I. H., Gansow, O. A., & Junghans, R. P. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-2-148 · Cited by 97 · see citing works
Scheinberg, D. A., Straus, D. J., Yeh, S.-D., Divgi, C. R., Garin‐Chesa, P., Graham, M. C., Pentlow, K. S., Coit, D. G., Oettgen, H. F., & Old, L. J. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.5.792 · Cited by 89 · see citing works
Determinants of the antitumor effect of radiolabeled monoclonal antibodies.
Knox, S. J., Levy, R., Miller, R., et al. (1990) · PubMed · Cited by 86 · see citing works
Preliminary validation of the opposing view method for quantitative gamma camera imaging
Eary, J. F., Appelbaum, F. L., Durack, L., et al. (1989) · Medical Physics · doi:10.1118/1.596347 · Cited by 71 · see citing works
Self-citationTreatment of Lymphoma With Radiolabeled Antibody: Elimination of Tumor Cells Lacking Target Antigen
Nourigat, C., Badger, C. C., & Bernstein, I. D. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.1.47 · Cited by 58 · see citing works
Self-citationIn vitro measurement of avidity of radioiodinated antibodies
Badger, C. C., Krohn, K. A., & Bernstein, I. D. (1987) · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · doi:10.1016/0883-2897(87)90033-x · Cited by 30 · see citing works
Self-citationProgress in the treatment of cutaneous T cell lymphomas with radiolabeled monoclonal antibodies
Rosen, S. T., Zimmer, A., Goldman-Leikin, R. E., et al. (1989) · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · doi:10.1016/0883-2897(89)90093-7 · Cited by 21 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [3]3. Freedman AS, Takvorian T, Anderson KC, et al. Autologous bone marrow ann v s o n oent related mortality in 100 patients in sensitive relapse. J Clin Oncol 1990; 8:784-91.
- [10]10. Fisher DR, Badger CC, Breitz H, et al. Internal radiation dosimetry for clinical testing of radiolabeled monoclonal antibodies. Antibody Immunoconjugates Radiopharm 1991;4:655-64.
- [15]15. Zimmer AM, Kaplan EH, Kazikiewicz JM, et al. Pharmacokinetics of I-131 T101 monoclonal antibody in patients with chronic lymphocytic leukemia. Antibody Immunoconjugates Radiopharm 1988;1:291-303.
Cited by
Sorted by citations
Kaminski, M. S., Estes, J., Zasadny, K. R., Francis, I. R., Ross, C. W., Tuck, M., Regan, D., Fisher, S., Gutierrez, J., Kroll, S., et al. (2000) · Blood · doi:10.1182/blood.v96.4.1259 · Cited by 525 · see citing works
Antibody-targeted radiation cancer therapy
Milenic, D. E., Brady, E. D., & Brechbiel, M. W. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1413 · Cited by 380 · see citing works
Vegt, E., de Jong, M., Wetzels, J. F. M., Masereeuw, R., Melis, M., Oyen, W. J. G., Gotthardt, M., & Boerman, O. C. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.075101 · Cited by 334 · see citing works
Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns
Wahl, R. L., Sgouros, G., Iravani, A., Jacene, H., Pryma, D., Saboury, B., Capala, J., & Graves, S. A. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262751 · Cited by 95 · see citing works
Tumor rim cells: From resistance to vascular targeting agents to complete tumor ablation
Seidi, K., Jahanban-Esfahlan, R., & Zarghami, N. (2017) · Tumor Biology · doi:10.1177/1010428317691001 · Cited by 41 · see citing works
- Authors
- Press, O. W., Eary, J. F., Appelbaum, F. R., Martin, P. J., Badger, C. C., Nelp, W. B., Glenn, S., Butchko, G., Fisher, D., Porter, B., Matthews, D. C., Fisher, L. D., & Bernstein, I. D.
- Affiliations
- University of Washington (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1993-10-21
- Volume
- 329
- Issue
- 17
- Pages
- 1219-1224
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320751441
- Cited by
- 644
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 4 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 18 · 2014: 13 · 2013: 13 · 2012: 15
- FWCI
- 38.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01 CA44991, P01CA044991)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- B-cell lymphoma, radioimmunotherapy, iodine-131, monoclonal antibodies, anti-CD20 monoclonal antibody, antibody biodistribution, relapsed lymphoma, dose escalation, myelosuppression, cardiopulmonary toxicity, complete remission
- MeSH terms
- Antibodies, Monoclonal, Antigens, Differentiation, B-Lymphocyte, Antigens, Neoplasm, Combined Modality Therapy, Glycoproteins, Humans, Iodine Radioisotopes, Middle Aged, Remission Induction, Spleen, Transplantation, Autologous, Antigens, CD, Bone Marrow Transplantation, Lymphoma, B-Cell, Radioimmunotherapy, Antigens, CD20, Tetraspanins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
