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The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease
Open accessAbstract
BACKGROUND: Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. We tested these interventions in 840 patients with various chronic renal diseases. METHODS: In study 1, 585 patients with glomerular filtration rates of 25 to 55 ml per minute per 1.73 m2 of body-surface area were randomly assigned to a usual-protein diet or a low-protein diet (1.3 or 0.58 g of protein per kilogram of body weight per day) and to a usual- or a low-blood-pressure group (mean arterial pressure, 107 or 92 mm Hg). In study 2, 255 patients with glomerular filtration rates of 13 to 24 ml per minute per 1.73 m2 were randomly assigned to the low-protein diet (0.58 g per kilogram per day) or a very-low-protein diet (0.28 g per kilogram per day) with a keto acid-amino acid supplement, and a usual- or a low-blood-pressure group (same values as those in study 1). An 18-to-45-month follow-up was planned, with monthly evaluations of the patients. RESULTS: The mean follow-up was 2.2 years. In study 1, the projected mean decline in the glomerular filtration rate at three years did not differ significantly between the diet groups or between the blood-pressure groups. As compared with the usual-protein group and the usual-blood-pressure group, the low-protein group and the low-blood-pressure group had a more rapid decline in the glomerular filtration rate during the first four months after randomization and a slower decline thereafter. In study 2, the very-low-protein group had a marginally slower decline in the glomerular filtration rate than did the low-protein group (P = 0.07). There was no delay in the time to the occurrence of end-stage renal disease or death. In both studies, patients in the low-blood-pressure group who had more pronounced proteinuria at base line had a significantly slower rate of decline in the glomerular filtration rate. CONCLUSIONS: Among patients with moderate renal insufficiency, the slower decline in renal function that started four months after the introduction of a low-protein diet suggests a small benefit of this dietary intervention. Among patients with more severe renal insufficiency, a very-low-protein diet, as compared with a low-protein diet, did not significantly slow the progression of renal disease.
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“Compared with a noneproteinlimited diet, a low-protein diet of 0.6 g/kg BW/d can prevent a decline in GFR of approximately 1 mL/min per year per 1.73 m 2 and is associated with a 30% decrease in reaching a dialysisdependent stage.114,115”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [115]
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“Reducing the amount of dietary protein below the recommended daily allowance of 0.8 g/kg/day is not recommended because it does not alter blood glucose levels, cardiovascular risk measures, or the course of GFR decline (46).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [46]
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“In people with CKD and diabetes, consuming protein below the recommended daily allowance of 0.8 g/kg/day is not recommended, because it does not alter blood glucose levels, cardiovascular risk measures, or the course of GFR decline (48).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [48]
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“Under those conditions, the development of malnutrition during a low-protein diet is an extremely rare event.115”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [115]
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923
(1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410020010002 · Cited by 1,974
Anthropometric standards for the assessment of growth and nutritional status
(1991) · Clinical Nutrition · doi:10.1016/0261-5614(91)90103-j · Cited by 1,197
The modification of diet in renal disease study group
Beck, G. J., Berg, R. L., Coggins, C. H., Gassman, J., Hunsicker, L. G., SCHLUCHTER, M. D., & Williams, G. W. (1991) · Controlled Clinical Trials · doi:10.1016/0197-2456(91)90069-x · Cited by 818
Self-citationA method for estimating nitrogen intake of patients with chronic renal failure
Maroni, B. J., Steinman, T. I., & Mitch, W. E. (1985) · Kidney International · doi:10.1038/ki.1985.10 · Cited by 789
Hemodynamically mediated glomerular injury and the progressive nature of kidney disease
Brenner, P. D. B. M. (1983) · Kidney International · doi:10.1038/ki.1983.72 · Cited by 617
PROSPECTIVE RANDOMISED TRIAL OF EARLY DIETARY PROTEIN RESTRICTION IN CHRONIC RENAL FAILURE
Rosman, J. B., ter Wee, P. M., Truus, S. M., Piers-Becht, P. M., Sluiter, W., & Donker, A. M. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90818-3 · Cited by 554
The Modification of Diet in Renal Disease Study
Klahr, S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198903303201310 · Cited by 454
Self-citation
Research works printed but not linked: 6
- Hunsicker LG, 1989, Semin Nephrol, 9, 380
- 10.1001/archinte.153.2.154 · DOI
- Levey AS, 1989, Kidney Int Suppl, 27, S
- Kopple JD, 1989, Kidney Int Suppl, 27, S
- Greene T, 1993, J Am Soc Nephrol, 3, 1819
- 10.2307/2281868 · DOI · Paper page
Cited by
Sorted by citations
Items 401–500 of 1,000
Should protein intake be restricted in predialysis patients?
Walser, M., Mitch, W. E., Maroni, B. J., & Kopple, J. D. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.055003771.x · Cited by 85
Urine Potassium Excretion, Kidney Failure, and Mortality in CKD
Leonberg‐Yoo, A. K., Tighiouart, H., Levey, A. S., Beck, G. J., & Sarnak, M. J. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.03.431 · Cited by 87
Self-citationProtein intake in renal disease.
Pollock, C. A., Ibels, L. S., Zhu, F. Y., Warnant, M., Caterson, R. J., Waugh, D. A., & Mahony, J. F. (1997) · Journal of the American Society of Nephrology · doi:10.1681/asn.v85777 · Cited by 85
Incident CKD after Radical or Partial Nephrectomy
Leppert, J. T., Lamberts, R. W., Thomas, I., Chung, B. I., Sonn, G. A., Skinner, E. C., Wagner, T. H., Chertow, G. M., & Brooks, J. D. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017020136 · Cited by 84
Chuahirun, T., Khanna, A., Kimball, K. T., & Wesson, D. E. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50009 · Cited by 84
Dussol, B., Moussi‐Francès, J., Morange, S., Somma-Delpéro, C., MUNDLER, O., & Berland, Y. (2004) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh650 · Cited by 84
Genetic Variation in the Renin-Angiotensin System and Progression of Diabetic Nephropathy
Jacobsen, P. K., Tarnow, L., Carstensen, B., Hovind, P. H., Poirier, O., & Parving, H. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092139.19587.51 · Cited by 82
Dussol, B., Iovanna, C., Raccah, D., Darmon, P., Morange, S., Vague, P., Vialettes, B., Oliver, C., Loundoun, A., & Berland, Y. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2005.07.003 · Cited by 84
Wang, L., Zhang, C., Chen, Z., Wang, X., Wang, K., Li, Y., Wang, R., Luo, X., Li, Y., & Li, J. (2018) · Journal of Cereal Science · doi:10.1016/j.jcs.2018.10.004 · Cited by 83
Weir, M. R., & Fink, J. C. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.08.041 · Cited by 83
Nitrogen Balance and Protein Requirements for Critically Ill Older Patients
Dickerson, R. N. (2016) · Nutrients · doi:10.3390/nu8040226 · Cited by 89
Koppe, L., Fouque, D. P., & Soulage, C. O. (2018) · Toxins · doi:10.3390/toxins10040155 · Cited by 86
Maroni, B. J., Staffeld, C., Young, V. R., Manatunga, A. K., & Tom, K. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119432 · Cited by 82
Human immunodeficiency virus-associated glomerulosclerosis
Humphreys, M. H. (1995) · Kidney International · doi:10.1038/ki.1995.299 · Cited by 83
Kovell, L. C., Ahmed, H. M., Misra, S. K., Whelton, S. P., Prokopowicz, G. P., Blumenthal, R. S., & McEvoy, J. W. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002315 · Cited by 91
Proteinuria predicting outcome in renal disease: Nondiabetic nephropathies (REIN)
Remuzzi, G., Chiurchiu, C. R., & Ruggenenti, P. L. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.09221.x · Cited by 81
Progression of Chronic Renal Disease in the Dog
Finco, D. R., Brown, S. A., Brown, C. A., Crowell, W. A., Cooper, T. A., & Barsanti, J. A. (1999) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1999.tb02204.x · Cited by 82
Hansen, H. P., Rossing, P. R., Tarnow, L., Nielsen, F. S., Jensen, B. R., & Parving, H. (1995) · Kidney International · doi:10.1038/ki.1995.238 · Cited by 82
Advances in the management of chronic kidney disease
Chen, T. K., Hoenig, M. P., Nitsch, D., & Grams, M. E. (2023) · BMJ · doi:10.1136/bmj-2022-074216 · Cited by 100
Cass, A., Cunningham, J., Wang, Z., Hoy, W. E., Arnold, P. C., & Snelling, P. L. (2002) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2002.tb04698.x · Cited by 79
Inhibition of RAS in diabetic nephropathy
Campbell, K. N., & Yacoub, R. (2015) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s37893 · Cited by 80
Long-term outcomes in nondiabetic chronic kidney disease
Menon, V., Wang, X., Sarnak, M. J., Hunsicker, L. G., Madero, M., Beck, G. J., Collins, A. J., Kusek, J. W., Levey, A. S., & Greene, T. (2008) · Kidney International · doi:10.1038/ki.2008.67 · Cited by 81
Self-citationKestenbaum, B. R., Seliger, S. L., Gillen, D. L., Wasse, H., Young, B. A., Sherrard, D. J., Weiss, N. S., & Stehman‐Breen, C. O. (2003) · Kidney International · doi:10.1111/j.1523-1755.2004.00368.x · Cited by 81
on behalf of the Low-Protein Diet Study Group, Koya, D., Haneda, M., Inomata, S., Suzuki, Y., Suzuki, D., Makino, H., Shikata, K., Murakami, Y., Tomino, Y., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1467-8 · Cited by 83
Peters, H., Border, W. A., & Noble, N. A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00994.x · Cited by 80
Juarez, G. M. F., Luño, J., Barrio, V., de Vinuesa, S. G., Praga, M., Goicoechea, M., Cachofeiro, V., Nieto, J., Vega, F. F., Tato, A., et al. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.07.011 · Cited by 82
Selamet, U., Tighiouart, H., Sarnak, M. J., Beck, G. J., Levey, A. S., Block, G. A., & Ix, J. H. (2015) · Kidney International · doi:10.1038/ki.2015.284 · Cited by 81
Self-citationBody Mass Index and Mortality in CKD
Madero, M., Sarnak, M. J., Wang, X., Castaneda‐Sceppa, C., Greene, T., Beck, G. J., Kusek, J. W., Collins, A. J., Levey, A. S., & Menon, V. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.06.004 · Cited by 79
Self-citationAdaptive Response to a Low-Protein Diet in Predialysis Chronic Renal Failure Patients
BERNHARD, J., Accent]RE, B. B. G., Laville, M., & Fouque, D. P. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1261249 · Cited by 79
Hirschberg, R. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118755 · Cited by 79
Mixed‐effects models for slope‐based endpoints in clinical trials of chronic kidney disease
Vonesh, E., Tighiouart, H., Ying, J., Heerspink, H. L., Lewis, J., Staplin, N., Inker, L., & Greene, T. (2019) · Statistics in Medicine · doi:10.1002/sim.8282 · Cited by 78
Modifiable Lifestyle Behaviors and CKD Progression: A Narrative Review
Schrauben, S. J., Apple, B. J., & Chang, A. R. (2022) · Kidney360 · doi:10.34067/kid.0003122021 · Cited by 83
Urinary sodium excretion and kidney failure in nondiabetic chronic kidney disease
Fan, L., Tighiouart, H., Levey, A. S., Beck, G. J., & Sarnak, M. J. (2014) · Kidney International · doi:10.1038/ki.2014.59 · Cited by 77
Self-citationNew insights into protein intake and progression of renal disease
Lentine, K. L., & Wrone, E. M. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200405000-00011 · Cited by 78
Effects of dual blockade of the renin-angiotensin system in primary proteinuric nephropathies
Luño, J., Barrio, V., Goicoechea, M. Á., González, C., de Vinuesa, S. G., Gómez-Preciado, F., Bernis, C., Espinosa, M., Ahijado, F. J., Gómez, J., et al. (2002) · Kidney International · doi:10.1046/j.1523-1755.62.s82.10.x · Cited by 78
Angiotensin-converting enzyme inhibitors and kidney protection: the AIPRI trial
Maschio, G., Alberti, D., Locatelli, F., Mann, J. F. E., Motolese, M., Ponticelli, C., Ritz, E., Janin, G., & Zucchelli, P. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199900001-00004 · Cited by 77
Sarafidis, P. A., & Ruilope, L. M. (2013) · Kidney International · doi:10.1038/ki.2013.355 · Cited by 75
Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy
Weldegiorgis, M., de Zeeuw, D., Li, L., Parving, H., Hou, F. F., Remuzzi, G., Greene, T., & Heerspink, H. J. L. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2017.08.010 · Cited by 77
Reducing the Risks of Cardiovascular Disease in Liver Allograft Recipients
Mells, G. F., & Neuberger, J. (2007) · Transplantation · doi:10.1097/01.tp.0000262706.28513.6a · Cited by 76
Romer, A., Seiler, D., Marincek, N., Brunner, P., Koller, M., Ng, Q. K. T., Maëcke, H. R., Müller‐Brand, J., Rochlitz, C. F., Briel, M., et al. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-013-2559-8 · Cited by 78
Beto, J. A., Ramirez, W. E., & Bansal, V. (2014) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.12.009 · Cited by 77
Xie, D., Joffe, M. M., Brunelli, S. M., Beck, G. J., Chertow, G. M., Fink, J. C., Greene, T., Hsu, C., Kusek, J. W., Landis, J. R., et al. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05631207 · Cited by 77
Self-citationBabazono, T., Nyumura, I., Toya, K., Hayashi, T., Ohta, M., Suzuki, K., Kiuchi, Y., & Iwamoto, Y. (2009) · Diabetes Care · doi:10.2337/dc08-2151 · Cited by 77
Ellis, D., Vats, A. N., Moritz, M. L., Reitz, S., Grosso, M. J., & Janosky, J. E. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00279-8 · Cited by 77
The Dietary Approaches to Stop Hypertension (DASH) Eating Pattern in Special Populations
Tyson, C. C., Nwankwo, C., Lin, P., & Svetkey, L. P. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0296-1 · Cited by 85
Effects of Severe Protein Restriction with Ketoanalogues in Advanced Renal Failure
Malvy, D. J.-M., Maingourd, C., Pengloan, J., Bagros, P., & Nivet, H. (1999) · Journal of the American College of Nutrition · doi:10.1080/07315724.1999.10718887 · Cited by 76
Frank, H., Gräf, J., Amann‐Gassner, U., Bratke, R., Daniel, H., Heemann, U. W., & Hauner, H. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27601 · Cited by 76
Parati, G., Ochoa, J. E., Bilo, G., Agarwal, R., Covic, A., Dekker, F. W., Fliser, D., Heine, G. H., Jager, K. J., Gargani, L., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06895 · Cited by 76
Can Renal Replacement Be Deferred by a Supplemented Very Low Protein Diet?
Walser, M., & Hill, S. B. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v101110 · Cited by 77
Ohya, Y., Arakawa, K., Arata, N., Arima, S., Arima, H., Asayama, K., Dohi, Y., Fukami, A., Furuhashi, M., Goto, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-025-02462-y · Cited by 91
Golik, M. V., & Lawrence, K. R. (2008) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.28.9.1125 · Cited by 77
Cardiovascular risk factors in patients with chronic kidney disease
van der Zee, S. A., Baber, U., Elmariah, S., Winston, J. A., & Fuster, V. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.121 · Cited by 82
Phisitkul, K., Hegazy, K., Chuahirun, T., Hudson, C., Wesson, D. E., Simoni, J. M., & Rajab, H. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e318156b799 · Cited by 75
Achievement of target blood pressure levels in chronic kidney disease: a salty question?
Nicola, L. D., Minutolo, R., Bellizzi, V., Zoccali, C., Cianciaruso, B., Andreucci, V. E., Fuíano, G., & Conte, G. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.01.009 · Cited by 74
Brinkworth, G. D., Buckley, J. D., Noakes, M., & Clifton, P. M. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.12.016 · Cited by 74
North American experience with Low protein diet for Non-dialysis-dependent chronic kidney disease
Kalantar‐Zadeh, K., Moore, L. W., Tortorici, A. R., Chou, J. A., St‐Jules, D. E., Aoun, A., Rojas‐Bautista, V., Tschida, A. K., Rhee, C. M., Shah, A. P., et al. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0304-9 · Cited by 74
Association of Systemic Hypertension with Renal Injury in Dogs with Induced Renal Failure
Finco, D. R. (2004) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2004.tb02547.x · Cited by 74
Retarding the progression of renal disease
Brenner, B. M. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.t01-2-00052.x · Cited by 74
Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure
Noels, H., van der Vorst, E. P. C., Rubin, S., Emmett, A., Marx, N., Tomaszewski, M., & Jankowski, J. (2025) · Circulation Research · doi:10.1161/circresaha.124.325488 · Cited by 92
Very long-term follow-up of living kidney donors
Fournier, C., Pallet, N., Cherqaoui, Z., Pucheu, S., Kreis, H., Méjean, A., Timsit, M., Landais, P., & Legendre, C. M. (2012) · Transplant International · doi:10.1111/j.1432-2277.2012.01439.x · Cited by 73
Ku, E., Glidden, D. V., Johansen, K. L., Sarnak, M. J., Tighiouart, H., Grimes, B. A., & Hsu, C. (2014) · Kidney International · doi:10.1038/ki.2014.376 · Cited by 75
Ribichini, F. L., Graziani, M. S., Gambaro, G., Pasoli, P., Pighi, M., Pesarini, G., Abaterusso, C., Yabarek, T., Brunelleschi, S., Rizzotti, P., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.02.026 · Cited by 73
Mathur, S., Syme, H. M., Brown, C. A., Elliot, J., Moore, P. A., Newell, M. A., Munday, J. S., Cartier, L. M., Sheldon, S. E., & Brown, S. A. (2002) · American Journal of Veterinary Research · doi:10.2460/ajvr.2002.63.833 · Cited by 73
Imran, T. F., Yick, F., Verma, S., Estiverne, C., Ogbonnaya-Odor, C., Thiruvarudsothy, S., Reddi, A. S., & Kothari, N. (2015) · Clinical and Experimental Nephrology · doi:10.1007/s10157-015-1179-y · Cited by 72
Taki, K., Nakamura, S., Miglinas, M., Enomoto, A., & Niwa, T. (2006) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2006.04.020 · Cited by 72
Caldeira, D., Amaral, T., David, C., & Sampaio, C. (2011) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2010.11.006 · Cited by 72
Late referral: loss of chance for the patient, loss of money for society
Jungers, P. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.3.371 · Cited by 72
Ketoacid Analogues Supplementation in Chronic Kidney Disease and Future Perspectives
Koppe, L., de Oliveira, M. C., & Fouque, D. P. (2019) · Nutrients · doi:10.3390/nu11092071 · Cited by 75
End-stage renal disease in China
Leishi, L. (1996) · Kidney International · doi:10.1038/ki.1996.41 · Cited by 71
Sharma, S. K., Zou, H., Togtokh, A., Ene‐Iordache, B., Carminati, S., Remuzzi, A., Wiebe, N., Ayyalasomayajula, B., Perico, N., Remuzzi, G., et al. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.06.022 · Cited by 73
Jiang, N., Qian, J., Sun, W., Lin, A., Cao, L., Wang, Q., Ni, Z., Wan, Y. P., Linholm, B., Axelsson, J., et al. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp085 · Cited by 71
Causes and Consequences of Chronic Kidney Disease: Implications for Managed Health Care
Weiner, D. E. (2007) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2007.13.s3.1 · Cited by 71
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Long-Term Effects of High-Protein Diets on Renal Function
Kamper, A., & Strandgaard, S. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034426 · Cited by 76
Management of hypertension in chronic kidney disease
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Georgianos, P. I., & Agarwal, R. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad118 · Cited by 92
Greene, T., Teng, C., Inker, L. A., Redd, A. M., Ying, J., Woodward, M., Coresh, J., & Levey, A. S. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.08.019 · Cited by 70
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August, P., & Suthanthiran, M. (2003) · Kidney International · doi:10.1046/j.1523-1755.64.s87.15.x · Cited by 70
Evidence‐based guide to slowing the progression of early renal insufficiency
Johnson, D. W. (2004) · Internal Medicine Journal · doi:10.1111/j.1444-0903.2004.t01-6-.x · Cited by 70
Dyslipidaemia and the progression of renal disease in chronic renal failure patients
Massy, Z. A., Nguyen‐Khoa, T., Lacour, B., Descamps‐Latscha, B., Man, N. K., & Jungers, P. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.10.2392 · Cited by 70
Systolic BP and Mortality in Older Adults with CKD
Weiss, J. W., Peters, D., Yang, X., Petrik, A. F., Smith, D. H., Johnson, E. S., Thorp, M. L., Morris, C. D., & O’Hare, A. M. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11391114 · Cited by 69
Predialysis Nephrology Care of Older Patients Approaching End-stage Renal Disease
Winkelmayer, W. C. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.360 · Cited by 71
A Comparison of Iothalamate-GFR and Serum Creatinine-Based Outcomes
Lewis, J. B., Greene, T., Appel, L. J., Contreras, G. N., Douglas, J. G., Lash, J., Toto, R. D., Lente, F. V., Wang, X., & Wright, J. T. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000146688.74084.a3 · Cited by 69
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Brown, W. W., Collins, A., Chen, S., King, K., Molony, D. A., Gannon, M. R., Politoski, G., & Keane, W. F. (2003) · Kidney International · doi:10.1046/j.1523-1755.63.s83.11.x · Cited by 68
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García-García, G., Tilde]o-Rentería, G. B., Luquin-Arellano, V. H., Gao, Z., Gill, J., & Tonelli, M. A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006121388 · Cited by 67
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Kelly, D., & Rothwell, P. M. (2019) · Stroke · doi:10.1161/strokeaha.119.025442 · Cited by 70
Post-translational modifications in kidney diseases and associated cardiovascular risk
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Terai, K., Nara, H., Takakura, K., Mizukami, K., Sanagi, M., Fukushima, S., Fujimori, A., Itoh, H., & Okada, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00108.x · Cited by 67
Yuen, D. A., Connelly, K. A., Advani, A., Liao, C., Kuliszewski, M. A., Trogadis, J. E., Thai, K., Advani, S. L., Zhang, Y., Kelly, D. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009543 · Cited by 67
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Hansen, H. P., Christensen, P. K., Tauber-Lassen, E., Klausen, A., Jensen, B. R., & Parving, H. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00274.x · Cited by 67
Cianciaruso, B., Bellizzi, V., Minutolo, R., Colucci, G., Bisesti, V., Russo, D., Conte, G., & Nicola, L. D. (1996) · Journal of the American Society of Nephrology · doi:10.1681/asn.v72306 · Cited by 67
Metadata
- Authors
- Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G.
- Affiliations
- National Institutes of Health (US)
- Tufts Medical Center (US)
- Cleveland Clinic (US)
- University of Pittsburgh (US)
- University of Iowa Hospitals and Clinics (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1994-03-31
- Volume
- 330
- Issue
- 13
- Pages
- 877-884
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2321986725
- Semantic Scholar
- 01e2c22d0073b85c7e2ba3a9327f2c898329d6af
- Cited by
- 2,328
- References
- 30
- Citations by year
- 2026: 25 · 2025: 53 · 2024: 56 · 2023: 66 · 2022: 64 · 2021: 74 · 2020: 73 · 2019: 82 · 2018: 81 · 2017: 98 · 2016: 82 · 2015: 84 · 2014: 100 · 2013: 92 · 2012: 92
- FWCI
- 51.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chronic kidney disease, protein restriction, very low protein diet, low-protein diet, blood pressure control, hypertension, glomerular filtration rate decline, end-stage renal disease, proteinuria, renal failure, disease progression, mortality, renal function decline, end-stage renal disease prevention, mortality prevention
- MeSH terms
- Blood Pressure, Chronic Disease, Dietary Proteins, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Hypertension, Kidney Diseases, Kidney Failure, Chronic, Polycystic Kidney Diseases, Male, Middle Aged, Linear Models
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