The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease
Open accessAbstract
BACKGROUND: Restricting protein intake and controlling hypertension delay the progression of renal disease in animals. We tested these interventions in 840 patients with various chronic renal diseases. METHODS: In study 1, 585 patients with glomerular filtration rates of 25 to 55 ml per minute per 1.73 m2 of body-surface area were randomly assigned to a usual-protein diet or a low-protein diet (1.3 or 0.58 g of protein per kilogram of body weight per day) and to a usual- or a low-blood-pressure group (mean arterial pressure, 107 or 92 mm Hg). In study 2, 255 patients with glomerular filtration rates of 13 to 24 ml per minute per 1.73 m2 were randomly assigned to the low-protein diet (0.58 g per kilogram per day) or a very-low-protein diet (0.28 g per kilogram per day) with a keto acid-amino acid supplement, and a usual- or a low-blood-pressure group (same values as those in study 1). An 18-to-45-month follow-up was planned, with monthly evaluations of the patients. RESULTS: The mean follow-up was 2.2 years. In study 1, the projected mean decline in the glomerular filtration rate at three years did not differ significantly between the diet groups or between the blood-pressure groups. As compared with the usual-protein group and the usual-blood-pressure group, the low-protein group and the low-blood-pressure group had a more rapid decline in the glomerular filtration rate during the first four months after randomization and a slower decline thereafter. In study 2, the very-low-protein group had a marginally slower decline in the glomerular filtration rate than did the low-protein group (P = 0.07). There was no delay in the time to the occurrence of end-stage renal disease or death. In both studies, patients in the low-blood-pressure group who had more pronounced proteinuria at base line had a significantly slower rate of decline in the glomerular filtration rate. CONCLUSIONS: Among patients with moderate renal insufficiency, the slower decline in renal function that started four months after the introduction of a low-protein diet suggests a small benefit of this dietary intervention. Among patients with more severe renal insufficiency, a very-low-protein diet, as compared with a low-protein diet, did not significantly slow the progression of renal disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Compared with a noneproteinlimited diet, a low-protein diet of 0.6 g/kg BW/d can prevent a decline in GFR of approximately 1 mL/min per year per 1.73 m 2 and is associated with a 30% decrease in reaching a dialysisdependent stage.114,115”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [115]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Reducing the amount of dietary protein below the recommended daily allowance of 0.8 g/kg/day is not recommended because it does not alter blood glucose levels, cardiovascular risk measures, or the course of GFR decline (46).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [46]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In people with CKD and diabetes, consuming protein below the recommended daily allowance of 0.8 g/kg/day is not recommended, because it does not alter blood glucose levels, cardiovascular risk measures, or the course of GFR decline (48).”
From 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [48]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Under those conditions, the development of malnutrition during a low-protein diet is an extremely rare event.115”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923
(1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410020010002 · Cited by 1,974
Anthropometric standards for the assessment of growth and nutritional status
(1991) · Clinical Nutrition · doi:10.1016/0261-5614(91)90103-j · Cited by 1,197
The modification of diet in renal disease study group
Beck, G. J., Berg, R. L., Coggins, C. H., Gassman, J., Hunsicker, L. G., SCHLUCHTER, M. D., & Williams, G. W. (1991) · Controlled Clinical Trials · doi:10.1016/0197-2456(91)90069-x · Cited by 818
Self-citationA method for estimating nitrogen intake of patients with chronic renal failure
Maroni, B. J., Steinman, T. I., & Mitch, W. E. (1985) · Kidney International · doi:10.1038/ki.1985.10 · Cited by 789
Hemodynamically mediated glomerular injury and the progressive nature of kidney disease
Brenner, P. D. B. M. (1983) · Kidney International · doi:10.1038/ki.1983.72 · Cited by 617
PROSPECTIVE RANDOMISED TRIAL OF EARLY DIETARY PROTEIN RESTRICTION IN CHRONIC RENAL FAILURE
Rosman, J. B., ter Wee, P. M., Truus, S. M., Piers-Becht, P. M., Sluiter, W., & Donker, A. M. (1984) · The Lancet · doi:10.1016/s0140-6736(84)90818-3 · Cited by 554
The Modification of Diet in Renal Disease Study
Klahr, S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198903303201310 · Cited by 454
Self-citation
Research works printed but not linked: 6
- Hunsicker LG, 1989, Semin Nephrol, 9, 380
- 10.1001/archinte.153.2.154 · DOI
- Levey AS, 1989, Kidney Int Suppl, 27, S
- Kopple JD, 1989, Kidney Int Suppl, 27, S
- Greene T, 1993, J Am Soc Nephrol, 3, 1819
- 10.2307/2281868 · DOI · Paper page
Cited by
Sorted by citations
Items 801–900 of 1,000
Intensive BP Control in Patients with CKD and Risk for Adverse Outcomes
Ku, E., McCulloch, C. E., Inker, L. A., Tighiouart, H., Schaefer, F. S., Wühl, E., Ruggenenti, P. L., Remuzzi, G., Grimes, B. A., & Sarnak, M. J. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000072 · Cited by 35
A Retrospective Review Assessing the Efficacy and Safety of Nitrofurantoin in Renal Impairment
Bains, A., Buna, D., & Hoag, N. A. (2009) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.3821/1913-701x-142.5.248 · Cited by 33
Nutritional Therapy, Phosphate Control and Renal Protection
Carrero, J. J., & Cozzolino, M. G. (2014) · Nephron Clinical Practice · doi:10.1159/000357679 · Cited by 34
Essential hypertension and risk of nephropathy: a reappraisal
Murea, M., & Freedman, B. I. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283366344 · Cited by 33
Hirsch, S., Hirsch, J., Bhatt, U. Y., & Rovin, B. H. (2012) · American Journal of Nephrology · doi:10.1159/000343453 · Cited by 33
A Primer on the Design, Conduct, and Interpretation of Clinical Trials
Appel, L. J. (2006) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02850806 · Cited by 33
Pruijm, M. T., Lu, Y., Megdiche, F., Piskunowicz, M., Milani, B., Stuber, M., Bachtler, M., Vogt, B., Burnier, M., & Pasch, A. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001406 · Cited by 33
Progression of Chronic Renal Disease
Klahr, S. (2001) · Heart Disease · doi:10.1097/00132580-200105000-00013 · Cited by 33
Self-citationSlowing the progression of renal failure
Praga, M. (2002) · Kidney International · doi:10.1046/j.1523-1755.61.s80.5.x · Cited by 33
Management of Chronic Kidney Disease in an Academic Primary Care Clinic
Israni, A. K., Korzelius, C. A., Townsend, R. R., & Mesler, D. E. (2002) · American Journal of Nephrology · doi:10.1159/000066296 · Cited by 33
Diabetic Renal Disease in African Americans
Crook, E. D. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200202000-00004 · Cited by 33
Protein restriction for diabetic renal disease
Waugh, N., & Robertson, A. (1997) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002181 · Cited by 33
Chronic Kidney Disease in the Older Adult Patient with Diabetes
Ravender, R., Roumelioti, M., Schmidt, D. W., Unruh, M. L., & Argyropoulos, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020348 · Cited by 34
Renin-Angiotensin-Aldosterone System Inhibition
Mercier, K., Smith, H. D., & Biederman, J. I. (2014) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2014.08.002 · Cited by 34
Dual blockade of the renin–angiotensin–aldosterone system in cardiac and renal disease
Slagman, M. C. J., Navis, G. J., & Laverman, G. D. (2010) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283361887 · Cited by 32
Phosphorus Additives and Albuminuria in Early Stages of CKD: A Randomized Controlled Trial
Chang, A. R., Miller, E. R., Anderson, C. A. M., Juraschek, S. P., Melough, M. M., White, K. N., Henry-Barron, B. J., Krekel, C., Oh, S., Charleston, J. B., et al. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.08.029 · Cited by 32
Li, Q., Wen, F., Wang, Y., Li, S., Lin, S., Qi, C., Chen, Z., Qiu, X., Zhang, Y., Zhang, S., et al. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00952-5 · Cited by 38
Hypertension in Chronic Kidney Disease (CKD): Diagnosis, Classification, and Therapeutic Targets
Georgianos, P. I., & Agarwal, R. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa209 · Cited by 34
Bellizzi, V., Garofalo, C., Ferrara, C., & Calella, P. (2022) · Nutrients · doi:10.3390/nu14030441 · Cited by 34
Zhang, P., Song, P. X. ‐., Qu, A., & Greene, T. (2007) · Biometrics · doi:10.1111/j.1541-0420.2007.00824.x · Cited by 32
Branched-Chain Amino Acids: Metabolism, Physiological Function, and Application
Cynober, L., & Harris, R. A. (2006) · Cited by 32
Tuttle, K. R., Dworkin, L. D., Henrich, W. L., Greco, B., Steffes, M. W., Tobe, S. W., Shapiro, J. I., Jamerson, K., Lyass, A., Pencina, K. M., et al. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.10491015 · Cited by 32
Fassett, R. G., Ball, M. J., Robertson, I. K., GERAGHTY, D. P., & Coombes, J. S. (2008) · BMC Nephrology · doi:10.1186/1471-2369-9-4 · Cited by 32
Chronic renal insufficiency: Current understandings and their implications
Bolton, W. K., & Kliger, A. S. (2000) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2000.19926 · Cited by 32
Percy, C., Freedman, D. S., Gilbert, T. J., White, L. L., Ballew, C., & Mokdad, A. H. (1997) · Journal of Nutrition · doi:10.1093/jn/127.10.2114s · Cited by 32
Hypertension in Chronic Kidney Disease: An Update on Diagnosis and Management
Gupta, A., Nagaraju, S. P., Bhojaraja, M. V., Swaminathan, S. M., & Mohan, P. B. (2023) · Southern Medical Journal · doi:10.14423/smj.0000000000001516 · Cited by 31
Sarafidis, P. A., Schmieder, R. E., Burnier, M., Persu, A., Januszewicz, A., Halimi, J., Arıcı, M., Ortíz, A., Wanner, C., Mancia, G., et al. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae041 · Cited by 34
MACGREGOR, M. S., & Taal, M. W. (2011) · Nephron Clinical Practice · doi:10.1159/000328062 · Cited by 31
Current Uses of Dietary Therapy for Patients with Far-Advanced CKD
Hanafusa, N., Lodebo, B. T., & Kopple, J. D. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09340916 · Cited by 34
Rebholz, C. M., Zheng, Z., Grams, M. E., Appel, L. J., Sarnak, M. J., Inker, L. A., Levey, A. S., & Coresh, J. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy202 · Cited by 31
Self-citationHopley, C. W., Kavanagh, S. T., Patel, M. R., Ostrom, C., Baumgärtner, I., Berger, J. S., Blomster, J., Fowkes, F. G. R., Jones, W. S., Katona, B. G., et al. (2019) · Vascular Medicine · doi:10.1177/1358863x19864172 · Cited by 32
Birudaraju, D., Cherukuri, L., Kinninger, A., Chaganti, B. T., Shaikh, K. A., Hamal, S. A., Flores, F. R., Roy, S. K., & Budoff, M. J. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.09.011 · Cited by 32
Optimal Protein Intake in Pre-Dialysis Chronic Kidney Disease Patients with Sarcopenia: An Overview
Isaka, Y. (2021) · Nutrients · doi:10.3390/nu13041205 · Cited by 35
Association of Plant Protein Intake With Risk of Incident CKD: A UK Biobank Study
Heo, G. Y., Koh, H. B., Kim, H. J., Kim, K. W., Jung, C., Kim, H. W., Chang, T. I., Park, J. T., Yoo, T., Kang, S., et al. (2023) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2023.05.007 · Cited by 32
Current and potential treatment options for hyperphosphatemia
Carfagna, F., Vecchio, L. D., Pontoriero, G., & Locatelli, F. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1476487 · Cited by 31
Hypertensive nephrosclerosis in African Americans
Toto, R. B. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00333.x · Cited by 31
Slowing the Progression of Adult Chronic Kidney Disease
Taal, M. W. (2004) · Drugs · doi:10.2165/00003495-200464200-00002 · Cited by 31
Post-transplant diabetes mellitus
Salvadori, M., Bertoni, E., Rosati, A., & Zanazzi, M. (2003) · Journal of Nephrology · doi:10.1093/joneph/16.5.626 · Cited by 31
Adequacy of dialysis revisited
Blake, P. G. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00891.x · Cited by 30
Komenda, P. V. J., & Levin, A. (2005) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000191911.57657.35 · Cited by 31
Diabetic Renal Disease: The Quest for Normotension—and Beyond
Mogensen, C. E. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb02077.x · Cited by 31
Dietary Protein Restriction in CKD: The Debate Continues
Ikizler, T. A. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.12.014 · Cited by 31
Marincek, N., Jörg, A.-C., Brunner, P., Schindler, C., Koller, M., Rochlitz, C. F., Müller‐Brand, J., Maëcke, H. R., Briel, M., & Walter, M. A. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-17 · Cited by 30
Kidney Disease and the Westernization and Industrialization of Food.
Kramer, H. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.11.012 · Cited by 27
Olivo, R. E., Davenport, C. A., Diamantidis, C. J., Bhavsar, N. A., Tyson, C. C., Hall, R. K., Bidulescu, A., Young, B. A., Mwasongwe, S. E., Pendergast, J., et al. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx230 · Cited by 30
Owada, A., Suda, S., & Hata, T. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01567-x · Cited by 30
Mehta, R. C., & Drawz, P. E. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0217-8 · Cited by 30
Prognostic impact of renal function in precapillary pulmonary hypertension
Kaiser, R., Seiler, S., Held, M., Bals, R., & Wilkens, H. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12131 · Cited by 31
Functional principal component analysis of glomerular filtration rate curves after kidney transplant
Dong, J. J., Wang, L., Gill, J., & Cao, J. (2017) · Statistical Methods in Medical Research · doi:10.1177/0962280217712088 · Cited by 30
Lin, Y., Lai, Y., Lin, Y., Peng, C., Chen, K., Chuang, M., Wu, K., & Chang, T. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12423 · Cited by 31
Preventive Effects of an Oral Sorbent on Nephropathy in Rats
Aoyama, I., Miyazaki, T., & Niwa, T. (1999) · Mineral and Electrolyte Metabolism · doi:10.1159/000057476 · Cited by 30
Metabolic Acidosis in CKD: Pathogenesis, Adverse Effects, and Treatment Effects
Raphael, K. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105187 · Cited by 29
Dumont, R. A., Seiler, D., Marincek, N., Brunner, P., Radojewski, P., Rochlitz, C. F., Müller‐Brand, J., Maëcke, H. R., Briel, M., & Walter, M. A. (2015) · Europe PMC (PubMed Central) · doi:10.7892/boris.67183 · Cited by 29
Landelijke Transmurale Afspraak Chronische nierschade
Hah, K., & Cajm, G. (2009) · Cited by 29
Intensive Versus Conventional Therapy to Slow the Progression of Idiopathic Glomerular Diseases
Bianchi, S., Bigazzi, R., & Campese, V. M. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.11.006 · Cited by 29
Resistant Hypertension Workup and Approach to Treatment
Makris, A. P., Seferou, M., & Papadopoulos, D. P. (2010) · International Journal of Hypertension · doi:10.4061/2011/598694 · Cited by 29
Piccoli, G. B., Nazha, M., Capizzi, I., Vigotti, F. N., Scognamiglio, S., Consiglio, V., Mongilardi, E., Bilocati, M., Avagnina, P., & Versino, E. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0413-5 · Cited by 29
Cost-Effective Strategies in the Prevention of Diabetic Nephropathy
Rippin, J. D., Barnett, A. H., & Bain, S. C. (2004) · PharmacoEconomics · doi:10.2165/00019053-200422010-00002 · Cited by 29
Ong, A. C. M., Newby, L. J., & Dashwood, M. R. (2003) · Nephron Experimental Nephrology · doi:10.1159/000068518 · Cited by 29
The Renoprotective Potential of Pentoxifylline in Chronic Kidney Disease
Lin, S., Chiang, W., Chen, Y., Lai, C., Tsai, T., & Hsieh, B. (2005) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70228-x · Cited by 29
Nutritional support in chronic renal failure: systematic review
Zarazaga, A., GARCÍA-DE-LORENZO, L., García‐Luna, P. P., García-Peris, P., Martínez, J. L., Lorenzo, V., Quecedo, L., & del Llano, J. (2001) · Clinical Nutrition · doi:10.1054/clnu.2001.0388 · Cited by 29
Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
Caletti, M. G., Lejarraga, H., Kelmansky, D., & Missoni, M. (2004) · Pediatric Nephrology · doi:10.1007/s00467-004-1516-y · Cited by 29
Rahman, M., & Smith, M. C. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.16.1743 · Cited by 29
Dosing angiotensin II blockers—beyond blood pressure
Peters, H., & Ritz, E. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.11.2568 · Cited by 29
HALL, W., Kusek, J. W., Kirk, K., Appel, L., Schulman, G., Agodoa, L., Glassock, R. J., Grim, C. E., Randall, O. S., & Massry, S. G. (1997) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(97)90125-6 · Cited by 29
Self-citationEnd-Stage Renal Disease Therapy
Friedman, E. A. (1996) · JAMA · doi:10.1001/jama.1996.03530380060032 · Cited by 29
Risk-directed management of chronic kidney disease
Blum, M. F., Neuen, B. L., & Grams, M. E. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00931-8 · Cited by 32
Fermentable carbohydrate and digestive nitrogen excretion
Younes, H., Alphonse, J.-C., Hadj-Abdelkader, M., & Rémésy, C. (2001) · Journal of Renal Nutrition · doi:10.1053/jren.2001.24359 · Cited by 28
Dietary Acid-Base Load and Risk of Chronic Kidney Disease in Adults: Tehran Lipid and Glucose Study.
Mirmiran, P., Yuzbashian, E., Bahadoran, Z., Asghari, G., & Azizi, F. (2016) · Iranian Journal of Kidney Diseases · Cited by 28
Rizzetto, F., Leal, V. D. O., Bastos, L. S., Fouque, D. P., & Mafra, D. (2017) · Renal Failure · doi:10.1080/0886022x.2017.1282374 · Cited by 28
Wiederkehr, M. R., Toto, R. D., Fenves, A. Z., & Ram, C. V. S. (2005) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2005.02.008 · Cited by 28
Li, H., Long, Q., Shao, C., Fan, H. Z., Li, Y., Huang, B., Gu, Y., Lin, S., Hao, C., & Chen, J. (2010) · Blood Purification · doi:10.1159/000321376 · Cited by 28
The Role of Liver in Determining Serum Colon-Derived Uremic Solutes
Lin, C., Liou, T., Pan, C., Wu, P., Sun, F., Liu, H., Chen, H., & Wu, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134590 · Cited by 28
Role of 24-h ambulatory blood pressure monitoring in children with chronic kidney disease
Gupta, D., Chaturvedi, S., Chandy, S., & Agarwal, I. (2015) · Indian Journal of Nephrology · doi:10.4103/0971-4065.148305 · Cited by 28
Role of observational studies versus clinical trials in ESRD research
Port, F. K. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07402.x · Cited by 28
Therapeutic measures in proteinuric nephropathy
Praga, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.09925.x · Cited by 28
Doi, S. Q., Rasaiah, S. B., Tack, I., Mysore, J. V., Kopchick, J. J., Moore, J. D., Hirszel, P., Striker, L. J., & Striker, G. E. (2001) · American Journal of Nephrology · doi:10.1159/000046270 · Cited by 28
Self-citationWhich Diet for Which Renal Failure
Beto, J. A. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00248-0 · Cited by 28
Shigihara, T., Sato, A., Hayashi, K., & Saruta, T. (2000) · Hypertension Research · doi:10.1291/hypres.23.219 · Cited by 28
Stoycheff, N., Pandya, K. A., Okparavero, A., Schiff, A. E., Levey, A. S., Greene, T., & Stevens, L. A. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq525 · Cited by 25
Self-citationKitada, M., Ogura, Y., Suzuki, T., Monno, I., Kanasaki, K., Watanabe, A., & Koya, D. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0255-1 · Cited by 26
Hall, J. A., Fritsch, D. A., Jewell, D. E., Burris, P. A., & Gross, K. L. (2018) · Veterinary Record · doi:10.1136/vr.104865 · Cited by 27
Dietary Protein, Kidney Function and Mortality: Review of the Evidence from Epidemiological Studies
Bilancio, G., Cavallo, P., Ciacci, C., & Círillo, M. (2019) · Nutrients · doi:10.3390/nu11010196 · Cited by 27
CKD Progression and Economic Burden in Individuals With CKD Associated With Type 2 Diabetes
Mullins, C. D., Pantalone, K. M., Betts, K. A., Song, J., Wu, A., Chen, Y., Kong, S. X., & Singh, R. (2022) · Kidney Medicine · doi:10.1016/j.xkme.2022.100532 · Cited by 26
Kidney Failure Detection and Predictive Analytics for ckd Using Machine Learning Procedures
Nimmagadda, S. M., Agasthi, S. S., Shai, A., Khandavalli, D. K. R., & Vatti, J. R. (2022) · Archives of Computational Methods in Engineering · doi:10.1007/s11831-022-09866-w · Cited by 27
Low-Protein Diet for Diabetic Nephropathy
Otoda, T., Kanasaki, K., & Koya, D. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0523-z · Cited by 27
Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
Mezzano, S. A., & Aros, C. (2005) · Revista médica de Chile · doi:10.4067/s0034-98872005000300011 · Cited by 27
Feasibility of providing nephrology services to remote communities with videoconferencing
Campbell, M., Akbari, A., Amos, S., & Keyes, C. (2011) · Journal of Telemedicine and Telecare · doi:10.1258/jtt.2011.110321 · Cited by 27
Trevest, K., Treadway, H., der Cingel, G. H.-V., Bailey, C., & Abdelhafiz, A. H. (2014) · Clinical Diabetes · doi:10.2337/diaclin.32.4.158 · Cited by 27
Shah, B., & Patel, Z. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0360-1 · Cited by 27
Pro: The rationale for dietary therapy for patients with advanced chronic kidney disease
Kopple, J. D., & Fouque, D. P. (2018) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx333 · Cited by 30
Very Low Protein Diet for Patients with Chronic Kidney Disease: Recent Insights
Micco, L. D., Lullo, L. D., Bellasi, A., & Iorio, B. R. D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050718 · Cited by 27
Glen W. Hartman Lecture. Science, creativity, and serendipity.
Meyers, M. A. (1995) · American Journal of Roentgenology · doi:10.2214/ajr.165.4.7676963 · Cited by 27
Younes, H., Alphonse, J.-C., Behr, S. R., Demigné, C., & Rémésy, C. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70213-1 · Cited by 27
Cardiovascular Mortality and Morbidity in Dialysis Patients
Eknoyan, G. (1999) · Mineral and Electrolyte Metabolism · doi:10.1159/000057429 · Cited by 27
Blood pressure management in the kidney transplant recipient
Weir, M. R. (2004) · Advances in Chronic Kidney Disease · doi:10.1053/j.arrt.2004.01.004 · Cited by 27
Genetic Initiation of Hypertensive and Diabetic Nephropathy
Freedman, B. I. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00481-0 · Cited by 27
Management of hypertension in patients with chronic kidney disease
Hamrahian, S. M. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0739-9 · Cited by 26
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
Estrella, M. M., Ballew, S. H., Sang, Y., Grams, M. E., Coresh, J., Surapaneni, A., de Pinho, N. A., Ärnlöv, J., Brenner, H., Carrero, J. J., et al. (2025) · JAMA · doi:10.1001/jama.2025.17578 · Cited by 26
Self-citationRenoprotective strategies in lupus nephritis: beyond immunosuppression
Griffin, B., & Lightstone, L. (2013) · Lupus · doi:10.1177/0961203313505927 · Cited by 26
Metadata
- Authors
- Klahr, S., Levey, A. S., Beck, G. J., Caggiula, A. W., Hunsicker, L., Kusek, J. W., & Striker, G.
- Affiliations
- National Institutes of Health (US)
- Tufts Medical Center (US)
- Cleveland Clinic (US)
- University of Pittsburgh (US)
- University of Iowa Hospitals and Clinics (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1994-03-31
- Volume
- 330
- Issue
- 13
- Pages
- 877-884
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2321986725
- Semantic Scholar
- 01e2c22d0073b85c7e2ba3a9327f2c898329d6af
- Cited by
- 2,328
- References
- 30
- Citations by year
- 2026: 25 · 2025: 53 · 2024: 56 · 2023: 66 · 2022: 64 · 2021: 74 · 2020: 73 · 2019: 82 · 2018: 81 · 2017: 98 · 2016: 82 · 2015: 84 · 2014: 100 · 2013: 92 · 2012: 92
- FWCI
- 51.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chronic kidney disease, protein restriction, very low protein diet, low-protein diet, blood pressure control, hypertension, glomerular filtration rate decline, end-stage renal disease, proteinuria, renal failure, disease progression, mortality, renal function decline, end-stage renal disease prevention, mortality prevention
- MeSH terms
- Blood Pressure, Chronic Disease, Dietary Proteins, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Hypertension, Kidney Diseases, Kidney Failure, Chronic, Polycystic Kidney Diseases, Male, Middle Aged, Linear Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
