Cited by 484Nephrotoxicity and Medicinal PlantsInflammatory mediators and NSAID effectsAcute Kidney Injury Research

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Risk of Kidney Failure Associated with the Use of Acetaminophen, Aspirin, and Nonsteroidal Antiinflammatory Drugs

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Perneger, Thomas V., Whelton, Paul K., Klag, Michael J.·1994·New England Journal of Medicine

DOI 10.1056/nejm199412223312502

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Abstract

BACKGROUND: People who take analgesic drugs frequently may be at increased risk of end-stage renal disease (ESRD), but the extent of this risk remains unclear. METHODS: We studied 716 patients treated for ESRD and 361 control subjects of similar age from Maryland, Virginia, West Virginia, and Washington, D.C. The study participants were interviewed by telephone about their past use of medications containing acetaminophen, aspirin, and other nonsteroidal antiinflammatory drugs (NSAIDs). For each analgesic drug, the average use (in pills per year) and the cumulative intake (in pills) were examined for any association with ESRD. RESULTS: Heavier acetaminophen use was associated with an increased risk of ESRD in a dose-dependent fashion. When persons who took an average of 0 to 104 pills per year were used for reference, the odds ratio of ESRD was 1.4 (95 percent confidence interval, 0.8 to 2.4) for those who took 105 to 365 pills per year and 2.1 (95 percent confidence interval, 1.1 to 3.7) for those who took 366 or more pills per year, after adjustment for race, sex, age, and intake of other analgesic drugs. When persons who had taken fewer than 1000 pills containing acetaminophen in their lifetime were used for reference, the odds ratio was 2.0 (95 percent confidence interval, 1.3 to 3.2) for those who had taken 1000 to 4999 pills and 2.4 (95 percent confidence interval, 1.2 to 4.8) for those who had taken 5000 or more pills. Approximately 8 to 10 percent of the overall incidence of ESRD was attributable to acetaminophen use. A cumulative dose of 5000 or more pills containing NSAIDs was also associated with an increased odds of ESRD (odds ratio, 8.8), but the use of aspirin was not. CONCLUSIONS: People who often take acetaminophen or NSAIDs have an increased risk of ESRD, but not those who often take aspirin.

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Applied logistic regression
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Estimating the population attributable risk for multiple risk factors using case-control data.
BRUZZI, P., GREEN, S. B., BYAR, D. P., BRINTON, L. A., & SCHAIRER, C. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114174 · Cited by 1,214
Best Subsets Logistic Regression
Hosmer, D. W., Jovanovic, B. D., & Lemeshow, S. A. (1989) · Biometrics · doi:10.2307/2531779 · Cited by 1,175
Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage
Nath, K. A. (1992) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80312-x · Cited by 977
Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease
Ciabattoni, G., Cinotti, G. A., Pierucci, A., Simonetti, B. M., Manzi, M., Pugliese, F. R., Barsotti, P., Pecci, G., Taggi, F., & Patrono, C. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402023100502 · Cited by 329
Analgesic Use and Chronic Renal Disease
Sandler, D. P., Smith, J. C., Weinberg, C. R., Buckalew, V. M., Dennis, V. W., Blythe, W. B., & Burgess, W. P. (1989) · New England Journal of Medicine · doi:10.1056/nejm198905113201903 · Cited by 254
Nonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal Disease
Sandler, D. P., Burr, F. R., & Weinberg, C. R. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-3-165 · Cited by 213
Renal Effects of Ibuprofen, Piroxicam, and Sulindac in Patients with Asymptomatic Renal Failure
Whelton, A., Stout, R. L., Spilman, P. S., & Klassen, D. K. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-8-568 · Cited by 203
An Epidemiologic Study of Abuse of Analgesic Drugs
Dubach, U. C., ROSNER, B. A., & Stürmer‎, T. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101173240304 · Cited by 123
Regular Analgesic Intake and the Risk of End-Stage Renal Failure
Pommer, W., Bronder, E., Greiser, E. M., Helmert, U., dagger, H. J. J., Klimpel, A., Borner, K., & Molzahn, M. (2008) · American Journal of Nephrology · doi:10.1159/000168002 · Cited by 111

Show all 15 references

Research works printed but not linked: 1

Spuhler O, 1953, Z Klin Med, 151, 1

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Yen, C., Sun, C., Leu, S., Wallace, C. G., Lin, Y., Chang, L., Chen, Y., Tsa, T.-H., Kao, Y. H., Shao, P., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-147 · Cited by 20
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Rathbun, W. B., Killen, C. E., Holleschau, A. M., & Nagasawa, H. T. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00144-x · Cited by 19
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Hansen, D. L., Hansen, E. H., & Holstein, B. E. (2009) · Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine · doi:10.1177/1363459309103918 · Cited by 18
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Singh, K., Betensky, R. A., Wright, A. T., Curhan, G. C., Bates, D. W., & Waikar, S. S. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.02420316 · Cited by 18
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Lavonas, E. J., Fries, J. F., Furst, D. E., Rothman, K. J., Stergachis, A. S., Vaida, A. J., Zelterman, D. A., Reynolds, K. M., Green, J. L., & Dart, R. C. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2012.629782 · Cited by 18
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Ruiz, J. G., & Lowenthal, D. T. (1997) · Geriatric Nephrology and Urology · doi:10.1023/a:1008288532636 · Cited by 18
“A cross-sectional study revealed that heavier acetaminophen use was associated with an increased risk of ESRD in a dose-dependent fashion [ 21 ].”
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Infante, A. F., Olmos, L. G., Gamarra, A. G., Meis, M. J. M., & Rodríguez, B. M. (2002) · Atención Primaria · doi:10.1016/s0212-6567(02)79120-8 · Cited by 18
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Sramek, J. J., Veroff, A. E., & Cutler, N. R. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.4.741 · Cited by 16
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Background
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Giltay, E. J., van Schaardenburg, D., Gooren, L. J., Kostense, P. J., & Dijkmans, B. A. C. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.9.541 · Cited by 14
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Background
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Norris, K. C., & Agodoa, L. Y. C. (2002) · PubMed Central · Cited by 15
Non-steroidal anti-inflammatory drugs
Whelton, A., Stürmer‎, T., & Porter, G. A., Jr. (2003) · Springer eBooks · doi:10.1007/1-4020-2586-6_14 · Cited by 15
Acute Effects of Acetaminophen on Renal Function and Urinary Excretion of Some Proteins and Enzymes in Patients with Kidney Disease
Mitic-Zlatkovic, M., & Stefanovic, V. (1999) · Renal Failure · doi:10.3109/08860229909045192 · Cited by 14
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“ForNSAIDs and analgesics, we divided subjects by the annual total number of pills receivedwithin the previous year into≦104 and>104 pills [24].”
Background
A longitudinal study of serum creatinine levels in patients of rheumatoid arthritis on long term NSAID therapy.
Pathan, E., Gaitonde, S., Rajadhyaksha, S. B., Sule, A., Mittal, G., & Joshi, V. (2003) · PubMed · Cited by 13
Diclofenac--Acetaminophen Combination Induced Acute Kidney Injury In Postoperative Pain Relief
Zhu, Y., Xu, P., Wáng, Q., Luo, J., Xiao, Y., Li, Y.-Y., Zhou, Y., Cave, A., & Banh, H. L. (2018) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3sh21 · Cited by 13
“A study investigating patients after general surgery reported an eight-fold increase in mortality in patients with perioperative AKI (11).”
Background
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Lee, J. J., & Simmons, D. L. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00054-9 · Cited by 13
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Ajuoga, E., Sansgiry, S. S., Ngo, C., & Yeh, R. F. (2008) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2007.08.001 · Cited by 13
Drug Treatment for Rheumatoid Arthritis
Langenegger, T., & Michel, B. A. (1999) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199909000-00004 · Cited by 13
Paracetamol und Metamizol in der Therapie chronischer Schmerzen
Hackenthal, E. (1997) · Der Schmerz · doi:10.1007/s004820050097 · Cited by 13
Commentary on the national kidney foundation position paper on analgesics and the kidney
Delzell, E., & Shapiro, S. (1996) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(96)90266-8 · Cited by 13
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Park, W. Y. (2020) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.20.027 · Cited by 17
“With similar pathophysiology, concurrent nephrotoxicity induced by acetaminophen has been raised as a concern over the past few decades [3,4].”
Background
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen
Weinstein, R. B., Ryan, P. B., Berlin, J. A., Schuemie, M. J., Swerdel, J. N., & Fife, D. (2020) · Drug Safety · doi:10.1007/s40264-020-00950-3 · Cited by 12
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Tang, K. S., & Shah, A. D. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1856369 · Cited by 12
“incidence is attributable to NSAID and acetaminophen use [73,80].”
Background
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Lecchi, M., D’Alonzo, L., Negro, A., & Martelletti, P. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.952631 · Cited by 12
“Similarly, aspirin is the NSAID associated to the lowest risk of developing hypertension when compared to other NSAIDs and paracetamol [63,64] and, probably for this reason, it is the only NSAID not associated to the development of kidney disease [65,66].”
Background
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AL‐Musawe, L., Torre, C., Guerreiro, J., Rodrigues, A. T., Raposo, J. F., Mota‐Filipe, H., & Martins, A. P. (2021) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-021-03107-y · Cited by 12
7 Pharmacotherapy and osteoarthritis
Brady, S. J., Brooks, P., Conaghan, P. G., & Kenyon, L. M. (1997) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(97)80008-8 · Cited by 12
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Heaton, P. C., Cluxton, R. J., & Moomaw, C. J. (2003) · Journal of the American Pharmacists Association · doi:10.1331/154434503322642606 · Cited by 12
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Soliman, S., Ahmed, R. M., Ahmed, M., Attia, A., & Soliman, A. R. (2024) · Romanian Journal of Internal Medicine · doi:10.2478/rjim-2024-0029 · Cited by 11
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Davey, G., Duncan, P., Aref-Adib, G., Venn, A. J., & Britton, J. R. (2006) · East African Medical Journal · doi:10.4314/eamj.v83i1.9358 · Cited by 11
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Yen, C., Lin, K., Leu, S., Sun, C., Chang, L., Chai, H., Chung, S., Chang, H., Ko, S., Chen, Y.-T., et al. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.03.009 · Cited by 11
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McGettigan, P., Platona, A., & Henry, D. A. (2000) · Inflammopharmacology · doi:10.1163/15685600052062734 · Cited by 11
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Chiang, S.-S., Tai, C.-W., Chung, C., Shiue, H.-S., Chen, J., Su, C., & Hsueh, Y. (2009) · Nutrition · doi:10.1016/j.nut.2009.04.021 · Cited by 10
“An early study reported that lifetime regular acetaminophen use was related to CKD [37], and another study found that subjects who often take acetaminophen or non-steroidal anti-inflammatory drugs have an increased risk of end-stage renal disease, but not for those who often take aspirin [38].”
Background
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BackgroundInfluential
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Harty, T., O'Shaughnessy, M. M., & Harney, S. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac460 · Cited by 10
Pharmacologic Pain Management Before and After Total Joint Replacement of the Hip and Knee
Bono, J. V., Robbins, C. E., Mehio, A. K., Aghazadeh, M., & Talmo, C. T. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.05.004 · Cited by 10
Analgesic Nephropathy–-A Painful Progression
Sampathkumar, K., Rajiv, A., & Sampathkumar, D. (2016) · Clinical Medicine Insights Urology · doi:10.4137/cmu.s13179 · Cited by 10
Over-the-counter medication use in residents of senior living communities: A survey study
Paliwal, Y., Jones, R. M., Moczygemba, L. R., Gendron, T. L., Nadpara, P. A., Parab, P. N., & Slattum, P. W. (2021) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2021.05.023 · Cited by 10
Temporary kidney dysfunction: supplementation with Meriva® in initial, transient kidney micro-macro albuminuria
Ledda, A. G., Belcaro, G. V., Feragalli, B., Hosoi, M., Cacchio, M., Luzzi, R., Dugall, M., & Cotellese, R. (2020) · Panminerva Medica · doi:10.23736/s0031-0808.18.03575-9 · Cited by 10
The disproportionate burden of kidney disease in those who can least afford it
Agodoa, L. Y. C., Norris, K. C., & Pugsley, D. J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.09700.x · Cited by 10
III. Incidence and causes of treated ESRD
(1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90082-9 · Cited by 10
Effects of Acetaminophen Exposure on Outcomes of Patients Receiving Immune Checkpoint Inhibitors for Advanced Non-Small-Cell Lung Cancer: A Propensity Score-Matched Analysis
Nelli, F., Virtuoso, A., Giannarelli, D., Fabbri, A., Berrìos, J. R. G., Marrucci, E., Fiore, C., & Ruggeri, E. M. (2023) · Current Oncology · doi:10.3390/curroncol30090589 · Cited by 9
“Exposure to APAP in our series was based on the level of intake according to relevant toxicological standards [35,36].”
Method
Prevalence of Chronic Kidney Disease in a High-Risk Population in Urban Lahore, Pakistan: A Cross-sectional Study
Khan, A., Cheema, M. F., Fatima, R., Cheema, S. S., Butt, Z. A., Gillani, S., Ahmad, A. K., Ullah, M. S., Jalal, U., & Cheema, S. U. R. (2024) · Cureus · doi:10.7759/cureus.63296 · Cited by 9
Safe and appropriate use of diclofenac in chronic kidney disease
Sheth, S., Thakur, S., Thorat, A. V., & Gupta, P. (2021) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_2358_20 · Cited by 9
Paracetamol and analgesic nephropathy: Are you kidneying me?
Waddington, F., Naunton, M., & Thomas, J. (2014) · International Medical Case Reports Journal · doi:10.2147/imcrj.s71471 · Cited by 9
“However, this study failed to adjust for the potential for patients using paracetamol to be concurrently using either phenacetin or NSAIDs when assessing association with renal failure.(20) O”
Influential
Chronic non-cancer pain in older people: current evidence for prescribing
Cowan, D. T. (2002) · British Journal of Community Nursing · doi:10.12968/bjcn.2002.7.8.10648 · Cited by 9
Pain Management in Pediatric Chronic Kidney Disease
Reis, A., Luecke, C. M., Davis, T. K., & Kakajiwala, A. K. (2018) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-23.3.192 · Cited by 9
Techniques d'analgésie conventionnelle: morphiniques et non morphiniques. Indications, effets indésirables et surveillance
Mazoit, J. (1998) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/s0750-7658(98)80041-5 · Cited by 9
NSAID: can renal side effects be avoided?
Frölich, J. C., & Stichtenoth, D. O. (1996) · Springer eBooks · doi:10.1007/978-94-010-9029-2_12 · Cited by 9
Renal Failure, Types, Causes and Etiology: A Review Article
Mohsen, I. H., Maaroof, R. J., & HarjanMohsen, A. (2023) · International Journal of Medical Science and Clinical Research Studies · doi:10.47191/ijmscrs/v3-i8-41 · Cited by 8
Acetaminophen (Tylenol): Johnson & Johnson and Consumer Safety
Trinkhaus, J., Nathan, J., Beane, L., & Meltzer, B. (1997) · The Journal of Law Medicine & Ethics · doi:10.1111/j.1748-720x.1997.tb01396.x · Cited by 8
“acetaminophen-based over-the-counter (OTC) analgesics, suggesting (1) development of hepatotoxicity, and (2) an increased risk of end-stage renal disease (ESRD).”
Background
Non-steroidal anti-inflammatory drugs
Olyaei, A. J., Whelton, A., Stürmer‎, T., & Porter, G. A., Jr. (2008) · Springer eBooks · doi:10.1007/978-0-387-84843-3_18 · Cited by 8
“[96], individuals judged to be taking an average annual dose of NSAID were not at additional risk of developing ESRD (adjusted RR 1.”
Background
Quality analysis of different marketed brands of paracetamol available in Bangladesh
Kar, A., Amin, M. N., Hossain, M. S., Mukul, M. E. H., Rashed, M. S. U., & Ibrahim, M. (2015) · International Current Pharmaceutical Journal · doi:10.3329/icpj.v4i9.24473 · Cited by 8
“There is a dose-dependent relationship between chronic use of paracetamol and an enhanced risk of end-stage renal disease, as demonstrated by a casecontrol study involving 1,077 individuals (Perneger et al., 1994).”
Background
Pros and Cons of Aspirin Prophylaxis for Prevention of Cardiovascular Events in Kidney Transplantation and Review of Evidence
Khalil, M. A. M., Khalil, M. S. U. D., Khamis, S. S. A., Alam, S., Daiwajna, R. G., Rajput, A. S., Alhaji, M. M., Chong, V. H., & Tan, J. C. (2019) · Advances in Preventive Medicine · doi:10.1155/2019/6139253 · Cited by 8
“Some studies implicated acetaminophen and phenacetin in the development of CKD but not aspirin [8, 9].”
Caffeine as a promoter of analgesic‐associated nephropathy – where is the evidence?
Fox, J. M., & Siebers, U. (2003) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00174.x · Cited by 8
The Effect of Descurainia Sophia Seed Extract on Nephrotoxicity Markers Induced by Acetaminophen in Mice
Moshaie-Nezhad, P., Bahari, Z., Jangravi, Z., Zarei, S. M., & Iman, M. (2021) · Journal of Advances in Medical and Biomedical Research · doi:10.30699/jambs.29.134.139 · Cited by 7
“The Mechanism of acetaminophen-induced renal damage had been reported previously (19-23).”
Background
Repeated preexposure or coexposure to arsenic differentially alters acetaminophen‐induced oxidative stress in rat kidney
Manimaran, A., Sarkar, S. N., & Sankar, P. (2009) · Environmental Toxicology · doi:10.1002/tox.20551 · Cited by 7
“Epidemiological studies show that longterm regular consumption of AP increases the relative risk of chronic renal disease (Sandler et al., 1989; Perneger et al., 1994).”
Background
Long-term toxicological effects of paracetamol in rats
Majeed, S., Ramadhan, M. A. K., & Saleh, W. M. M. (2013) · Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences · doi:10.33899/ijvs.2013.82959 · Cited by 7
“4 for cumulative lifetime intake of more than 5000 tablets containing paracetamol (7).”
BackgroundInfluential
Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice
Moshaie-Nezhad, P., Hosseini, S. M., Yahyapour, M., Iman, M., & Khamesipour, A. (2019) · Journal of Herbmed Pharmacology · doi:10.15171/jhp.2019.11 · Cited by 7
SURVEY FOR POTENTIAL RISK FACTORS FOR SUSCEPTIBILITY TO CHRONIC KIDNEY DISEASE IN HAIL REGION, KSA
Ginawi, I., Ahmed, H., Ashankyty, I., Altamimi, T. N., Almogbel, M., Alsuedaa, A., Akbar, D., Albeladi, F., Alrashdan, A., Jastaniah, S., et al. (2013) · Management in Health · doi:10.5233/mih.v17i2.269 · Cited by 9
Safe pharmacologic treatment strategies for osteoarthritis pain in African Americans with hypertension, and renal and cardiac disease.
Johnson, J. C., & Weinryb, J. (2006) · PubMed Central · Cited by 7
Patterns and Predictors of Non-Prescription Medicine Use among Malaysian Pharmacy Patrons: A National Cross Sectional Study
Hassali, M. A., Yahaya, A. H. M., Shafie, A. A., Saleem, F., Chua, G. N., & Aljadhey, H. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059231 · Cited by 7
“The misuse of such medicines could lead to potential risks such as gastrointestinal bleeding and renal impairment [17,18].”
Background
Postępowanie w okresie okołooperacyjnym u chorych z ryzykiem wystąpienia ostrego uszkodzenia nerek, poddawanych operacjom kardiochirurgicznym
Krzych, Ł. J., Wybraniec, M. T., Chudek, J. T., & Bochenek, A. A. (2013) · Anestezjologia, Intensywna Terapia · doi:10.5603/ait.2013.0033 · Cited by 7
Estimated Risks of Fatal Events Associated with Acetaminophen, Ibuprofen, and Naproxen Sodium Used for Analgesia
Rothman, K. J. (2013) · Advances in Pharmacoepidemiology & Drug Safety · doi:10.4172/2167-1052.1000124 · Cited by 7
“For naproxen sodium, low estimates resulted in an estimate of an increase of 86 deaths per million person-years for those switching from acetaminophen to naproxen, and 53 deaths per million personyears for the high estimates [17-27].”
Background
Papillary necrosis in a ballet dancer with no history of analgesic abuse
Brenke, B., Nahm, A., & Ritz, E. (1996) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/11.12.2501 · Cited by 7
Nonsteroidal Anti-inflammatory Drugs
Ballou, L. R., & Wang, B. W. E. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10054-3 · Cited by 7

Authors: Perneger, T. V., Whelton, P. K., & Klag, M. J.
Affiliations: University of Geneva (CH)
Johns Hopkins University (US)
ORCID: Perneger, Thomas V.
Whelton, Paul K.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1994-12-22
Volume: 331
Issue: 25
Pages: 1675-1679
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199412223312502
OpenAlex: W2320758398
Cited by: 484
References: 15
Citations by year: 2026: 3 · 2025: 5 · 2024: 18 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 21 · 2019: 19 · 2018: 11 · 2017: 10 · 2016: 16 · 2015: 17 · 2014: 17 · 2013: 20 · 2012: 20
FWCI: 20.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Agency for Healthcare Research and Quality (R03-HS06978-01)
National Center for Research Resources (5MOIRR00722, RR 00035)
Topics: Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
Keywords: end-stage renal disease, renal failure, paracetamol, aspirin, nonsteroidal anti-inflammatory drugs, analgesic use, dose-response relationship, attributable risk, drug-induced nephrotoxicity
MeSH terms: Acetaminophen, Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Drug Utilization, Female, Humans, Kidney Failure, Chronic, Male, Middle Aged, Risk Factors, Causality, Confidence Intervals, Odds Ratio, Case-Control Studies

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Risk of Kidney Failure Associated with the Use of Acetaminophen, Aspirin, and Nonsteroidal Antiinflammatory Drugs

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