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Risk of Kidney Failure Associated with the Use of Acetaminophen, Aspirin, and Nonsteroidal Antiinflammatory Drugs
Open accessAbstract
BACKGROUND: People who take analgesic drugs frequently may be at increased risk of end-stage renal disease (ESRD), but the extent of this risk remains unclear. METHODS: We studied 716 patients treated for ESRD and 361 control subjects of similar age from Maryland, Virginia, West Virginia, and Washington, D.C. The study participants were interviewed by telephone about their past use of medications containing acetaminophen, aspirin, and other nonsteroidal antiinflammatory drugs (NSAIDs). For each analgesic drug, the average use (in pills per year) and the cumulative intake (in pills) were examined for any association with ESRD. RESULTS: Heavier acetaminophen use was associated with an increased risk of ESRD in a dose-dependent fashion. When persons who took an average of 0 to 104 pills per year were used for reference, the odds ratio of ESRD was 1.4 (95 percent confidence interval, 0.8 to 2.4) for those who took 105 to 365 pills per year and 2.1 (95 percent confidence interval, 1.1 to 3.7) for those who took 366 or more pills per year, after adjustment for race, sex, age, and intake of other analgesic drugs. When persons who had taken fewer than 1000 pills containing acetaminophen in their lifetime were used for reference, the odds ratio was 2.0 (95 percent confidence interval, 1.3 to 3.2) for those who had taken 1000 to 4999 pills and 2.4 (95 percent confidence interval, 1.2 to 4.8) for those who had taken 5000 or more pills. Approximately 8 to 10 percent of the overall incidence of ESRD was attributable to acetaminophen use. A cumulative dose of 5000 or more pills containing NSAIDs was also associated with an increased odds of ESRD (odds ratio, 8.8), but the use of aspirin was not. CONCLUSIONS: People who often take acetaminophen or NSAIDs have an increased risk of ESRD, but not those who often take aspirin.
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“Renal damage is also produced by chronic use of paracetamol; in a case-control study involving 1,077 subjects who frequently took paracetamol, a dose-dependent relationship between heavier paracetamol use and an increased risk of end-stage renal disease was demonstrated (160).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [160]
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Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Estimating the population attributable risk for multiple risk factors using case-control data.
BRUZZI, P., GREEN, S. B., BYAR, D. P., BRINTON, L. A., & SCHAIRER, C. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114174 · Cited by 1,214
Best Subsets Logistic Regression
Hosmer, D. W., Jovanovic, B. D., & Lemeshow, S. A. (1989) · Biometrics · doi:10.2307/2531779 · Cited by 1,175
Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage
Nath, K. A. (1992) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(12)80312-x · Cited by 977
Effects of Sulindac and Ibuprofen in Patients with Chronic Glomerular Disease
Ciabattoni, G., Cinotti, G. A., Pierucci, A., Simonetti, B. M., Manzi, M., Pugliese, F. R., Barsotti, P., Pecci, G., Taggi, F., & Patrono, C. (1984) · New England Journal of Medicine · doi:10.1056/nejm198402023100502 · Cited by 329
Analgesic Use and Chronic Renal Disease
Sandler, D. P., Smith, J. C., Weinberg, C. R., Buckalew, V. M., Dennis, V. W., Blythe, W. B., & Burgess, W. P. (1989) · New England Journal of Medicine · doi:10.1056/nejm198905113201903 · Cited by 254
Nonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal Disease
Sandler, D. P., Burr, F. R., & Weinberg, C. R. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-3-165 · Cited by 213
Renal Effects of Ibuprofen, Piroxicam, and Sulindac in Patients with Asymptomatic Renal Failure
Whelton, A., Stout, R. L., Spilman, P. S., & Klassen, D. K. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-8-568 · Cited by 203
An Epidemiologic Study of Abuse of Analgesic Drugs
Dubach, U. C., ROSNER, B. A., & Stürmer, T. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101173240304 · Cited by 123
Regular Analgesic Intake and the Risk of End-Stage Renal Failure
Pommer, W., Bronder, E., Greiser, E. M., Helmert, U., dagger, H. J. J., Klimpel, A., Borner, K., & Molzahn, M. (2008) · American Journal of Nephrology · doi:10.1159/000168002 · Cited by 111
Research works printed but not linked: 1
- Spuhler O, 1953, Z Klin Med, 151, 1
Cited by
Sorted by citations
KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease
Stevens, P. E., Ahmed, S. B., Carrero, J. J., Foster, B., Francis, A., Hall, R. K., Herrington, W. G., Hill, G., Inker, L. A., Kazancıoğlu, R., et al. (2024) · Kidney International · doi:10.1016/j.kint.2023.10.018 · Cited by 8,530
Chronic kidney disease: the global challenge
Nahas, A. M. E., & Bello, A. K. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17789-7 · Cited by 1,191
Guidelines for the medical management of osteoarthritis
Hochberg, M. C., Altman, R. D., Brandt, K. D., Clark, B. M., Dieppe, P. A., Griffin, M. R., Moskowitz, R. W., & Schnitzer, T. J. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780381103 · Cited by 966
Risk factors for chronic kidney disease: an update
Kazancıoğlu, R. (2013) · Kidney International Supplements · doi:10.1038/kisup.2013.79 · Cited by 750
Paracetamol: New Vistas of an Old Drug
Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., & Leone, S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00250.x · Cited by 674
Brandow, A. M., Carroll, C. P., Creary, S. E., Edwards, R., Glassberg, J., Hurley, R. W., Kutlar, A., Seisa, M. O., Stinson, J., Strouse, J. J., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001851 · Cited by 486
RONS and Oxidative Stress: An Overview of Basic Concepts
Aranda‐Rivera, A. K., Cruz‐Gregorio, A., Arancibia‐Hernández, Y. L., Cruz, E. Y. H., & Pedraza‐Chaverrí, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 430
“For example, NSAIDs and rifampin are common causes of acute inflammation of the interstitial tissue, while acyclovir and antibiotics such as ampicillin have been common causes of insoluble crystal formation in kidney tissue [170].”
Bioactive lipids, inflammation and chronic diseases
Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 373
Garg, A. X., KIBERD, B. A., Clark, W. F., Haynes, R. B., & Clase, C. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00356.x · Cited by 355
Drug-associated renal dysfunction and injury
Choudhury, D., & Ahmed, Z. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0076 · Cited by 345
“acetaminophen and aspirin) found that people taking large cumulative doses of acetaminophen and NSAIDs were at increased risk of developing end-stage renal disease”
Oral and Dental Aspects of Chronic Renal Failure
Proctor, R., Kumar, N., Stein, A., Moles, D. R., & Porter, S. R. (2005) · Journal of Dental Research · doi:10.1177/154405910508400301 · Cited by 344
“Impaired renal function can result in high blood levels of drugs or their metabolites (Perneger et al., 1994); thus, it may be necessary to reduce the dosage of many drugs or use alternative agents (Bennett et al., 1983).”
BackgroundRisk of developing end-stage renal disease in a cohort of mass screening
Iseki, K., Iseki, C., Ikemiya, Y., & Fukiyama, K. (1996) · Kidney International · doi:10.1038/ki.1996.111 · Cited by 340
NSAID Use and Progression of Chronic Kidney Disease
Gooch, K. L., Culleton, B. F., Manns, B., Zhang, J., Alfonso, H. S., Tonelli, M. A., Frank, C., Klarenbach, S. W., & Hemmelgarn, B. R. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.02.015 · Cited by 333
Nonsteroidal Antiinflammatory Drugs, Acetaminophen, and the Risk of Cardiovascular Events
Chan, A. T., Manson, J. E., Albert, C. M., Chae, C. U., Rexrode, K. M., Curhan, G. C., Rimm, E. B., Willett, W. C., & Fuchs, C. S. (2006) · Circulation · doi:10.1161/circulationaha.105.595793 · Cited by 319
Antidepressant-Induced Sexual Dysfunction
Gregorian, R. S., Golden, K. A., Bahce, A., Goodman, C., Kwong, W. J., & Khan, Z. M. (2002) · Annals of Pharmacotherapy · doi:10.1345/aph.1a195 · Cited by 320
Long‐term adverse effects of paracetamol – a review
McCrae, J. C., Morrison, E. E., MacIntyre, I. M., Dear, J. W., & Webb, D. J. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13656 · Cited by 308
“with ~10% of the overall incidence of ESRD attributable to paracetamol use [113].”
BackgroundAround-the-Clock, Controlled-Release Oxycodone Therapy for Osteoarthritis-Related Pain
Roth, S. H., Fleischmann, R., Burch, F., Dietz, F., Bockow, B. I., Rapoport, R. J., Rutstein, J. E., & Lacouture, P. G. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.6.853 · Cited by 305
Nonsteroidal Anti-Inflammatory Drugs and the Kidney
Hörl, W. H. (2010) · Pharmaceuticals · doi:10.3390/ph3072291 · Cited by 298
“In contrast, some case-control studies found an association between NSAIDs and the risk of chronic renal dysfunction [215,219].”
ResultDrug-Induced Nephrotoxicity and Its Biomarkers
Kim, S. Y., & Moon, A. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.3.268 · Cited by 289
“Chronic interstitial nephritis occurs frequently by long-term use of calcineurin inhibitors, lithium, some anticancer drugs or analgesics (Perneger et al., 1994; Fored et al., 2001; Isnard Bagnis, et al., 2004; Rodriguez-Iturbe and Garcia Garcia, 2010).”
BackgroundAcetaminophen, Aspirin, and Chronic Renal Failure
Fored, C. M., Ejerblad, E., Lindblad, P., Fryzek, J. P., Dickman, P. W., Signorello, L. B., Lipworth, L., Elinder, C., Blot, W. J., McLaughlin, J. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010323 · Cited by 289
Predicting initiation and progression of chronic kidney disease: Developing renal risk scores
Taal, M. W., & Brenner, B. M. (2006) · Kidney International · doi:10.1038/sj.ki.5001794 · Cited by 294
Clinical practice guideline on pregnancy and renal disease
Wiles, K., Chappell, L. C., Clark, K., Elman, L., Hall, M., Lightstone, L., Mohamed, G., Mukherjee, D., Nelson‐Piercy, C., Webster, P., et al. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1560-2 · Cited by 305
Baker, M. L., & Perazella, M. A. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.03.023 · Cited by 250
“Similarly, a casecontrol study found an association between stage 5 CKD development and NSAIDs only in users of the highest quantities.(79)”
BackgroundLai, M., Wang, S., Chen, P., Chen, Y., & Wang, J.-D. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp467 · Cited by 233
“an increased risk of renal damage or renal cancer in previous studies (23,24), to prevent confounding of our results by analgesic use, we excluded subjects who were ever prescribed more than a total of”
A randomized trial of acupuncture as an adjunctive therapy in osteoarthritis of the knee
Berman, B. (1999) · British journal of rheumatology · doi:10.1093/rheumatology/38.4.346 · Cited by 225
“Management of OA, mechanism of acupuncture analgesia [16, 17] provided however, is often ineffective and pharmacological agents, an overview of the neural, humoral and biomagnetic especially NSAIDs, have the potential to cause unpleasmechanisms that may contribute to the production of ant and sometimes dangerous side-…”
BackgroundThe global challenge of chronic kidney disease
Nahas, M. E. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00774.x · Cited by 200
Paulose‐Ram, R., Hirsch, R., Dillon, C. F., Losonczy, K. G., Cooper, M., & Ostchega, Y. (2002) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.755 · Cited by 199
“Multiple studies have identified an increased risk of acetaminophen-related renal or hepatic toxicity with the ingestion of large or repeated doses of acetaminophen, after recent fasting, or with concurrent alcohol intake.(15,13,10) Although dosage information was not collected in NHANES III, this study showed that ap…”
BackgroundGuidelines for monitoring drug therapy in rheumatoid arthritis
American College of Rheumatology AD Hoc Committee on Clinical Guidelines (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390503 · Cited by 193
The renal effects of nonsteroidal anti-inflammatory drugs: Summary and recommendations
Bennett, W. M., Henrich, W. L., & Stoff, J. S. (1996) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(96)90570-3 · Cited by 190
Oyelade, T., Alqahtani, J. S., & Canciani, G. (2020) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed5020080 · Cited by 194
“Although the majority of CKD cases are linked to diabetes and hypertension [8], other risk factors, including genetics [9], recreational drugs and alcohol consumption [10], obesity [11], gender [12,13], age [12], lower birth weight [14], smoking status [15,16], ethnicity [17], family history of CKD [18] and acute kidn…”
BackgroundDENTAL CONSIDERATIONS FOR THE PATIENT WITH RENAL DISEASE RECEIVING HEMODIALYSIS
Rossi, S. S. D., & Glick, M. (1996) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1996.0171 · Cited by 184
Confounding by Indication in Epidemiologic Studies of Commonly Used Analgesics
Signorello, L. B., McLaughlin, J. K., Lipworth, L., Friis, S. R., Sørensen, H. T., & Blot, W. J. (2002) · American Journal of Therapeutics · doi:10.1097/00045391-200205000-00005 · Cited by 178
Simms, R. W., Kwoh, C. K., Anderson, L. G., Erlandson, D. M., Greene, J. M., Kelleher, M. E., O’Dell, J. R., Partridge, A. J., Roberts, W. N., Robbins, M. L., et al. (1996) · PubMed · Cited by 178
Epidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs
Hernández–Dı́az, S., & García‐Rodríguez, L. A. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00682-3 · Cited by 175
Lifetime Nonnarcotic Analgesic Use and Decline in Renal Function in Women
Curhan, G. C., Knight, E. L., ROSNER, B. A., Hankinson, S. E., & Stampfer, M. J. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.14.1519 · Cited by 165
Massage Therapy for Osteoarthritis of the Knee
Perlman, A. I. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2533 · Cited by 169
Nefropatía terminal en pacientes de un hospital de referencia en El Salvador
Gárcía-Trabanino, R., Aguilar, R., Silva, C. R., Mercado, M. O., & Merino, R. L. (2002) · Revista Panamericana de Salud Pública · doi:10.1590/s1020-49892002000900009 · Cited by 160
Pharmacologic treatments for temporomandibular disorders
Dionne, R. A. (1997) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/s1079-2104(97)90104-9 · Cited by 158
Herbal medicines for the treatment of osteoarthritis: a systematic review
Long, L., Soeken, K. L., & Ernst, E. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.7.779 · Cited by 155
Antidepressants and suicide: what is the balance of benefit and harm
Gunnell, D., & Ashby, D. (2004) · BMJ · doi:10.1136/bmj.329.7456.34 · Cited by 150
Non-steroidal anti-inflammatory drugs and chronic kidney disease progression: a systematic review
Nderitu, P., Doos, L., Jones, P. W., Davies, S. J., & Kadam, U. T. (2013) · Family Practice · doi:10.1093/fampra/cms086 · Cited by 150
Paracetamol-Induced Renal Tubular Injury
Lorz, C., Justo, P., Sanz, A. B., Subirá, D., Egido, J., & Ortíz, A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000111289.91206.b0 · Cited by 149
Drugs for pain management in dentistry
Hargreaves, K., & Abbott, P. V. (2005) · Australian Dental Journal · doi:10.1111/j.1834-7819.2005.tb00378.x · Cited by 146
“Despite this, it has been suggested that the use of 6000mg per day for a short period of time may have therapeutic benefit without unduly increasing risks.(47)”
BackgroundInfluentialEvolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease
Li, Z., Polhemus, D. J., & Lefer, D. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311134 · Cited by 142
The efficacy of combination analgesic therapy in relieving dental pain
MEHLISCH, D. R. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0300 · Cited by 141
De Broe, M. E., & Elseviers, M. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380707 · Cited by 139
Nonsteroidal Anti-inflammatory Drugs and the Risk of Hospitalization for Acute Renal Failure
Perez‐Gutthann, S. (1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440200041005 · Cited by 141
Nonsteroidal Antiinflammatory Drugs as a Trigger of Clinical Heart Failure
Rodríguez, L. A. G., & Hernández–Dı́az, S. (2003) · Epidemiology · doi:10.1097/01.ede.0000034633.74133.c3 · Cited by 138
Risk of End-stage Renal Disease Associated with Alcohol Consumption
Perneger, T., Whelton, P. K., Puddey, I. B., & Klag, M. J. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009958 · Cited by 137
“Modifiable risk factors for kidney failure that have been identified in population-ba sed studies include high blood pressure (2), diabetes mellitus (3), exposure to occupational nephrotoxins (4), and chronic use of analgesics ( 5 ).”
BackgroundSelf-citationStricker, B. H. C., & Stijnen, T. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9451-7 · Cited by 127
Analgesic Use and Renal Function in Men
Rexrode, K. M. (2001) · JAMA · doi:10.1001/jama.286.3.315 · Cited by 122
“When we examined men who consumed 7000 or more pills of each analgesic during the study (.500 pills/ year) the RRs of elevated creatinine levels were 0.51 (95% CI, 0.16-1.67) for acetaminophen, 1.35 (95% CI, 0.57-3.18) for aspirin, and 1.61 (95% CI, 0.90-2.90) for other NSAIDs.”
BackgroundInfluentialPlantinga, L., Grubbs, V., Sarkar, U., Hsu, C., Hedgeman, E., Robinson, B. M., Saran, R., Geiss, L. S., Burrows, N. R., Eberhardt, M. S., et al. (2011) · The Annals of Family Medicine · doi:10.1370/afm.1302 · Cited by 117
The genotoxicity and carcinogenicity of paracetamol: a regulatory (re) view
Bergman, K., Müller, L., & Teigen, S. W. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(95)00185-9 · Cited by 116
Perioperative Management of Patients With End-Stage Renal Disease
Kanda, H., Hirasaki, Y., Iida, T., Kanao-Kanda, M., Toyama, Y., Chiba, T., & Kunisawa, T. (2017) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2017.04.019 · Cited by 126
Use and abuse of over-the-counter analgesic agents.
Abbott, F. V., & Fraser, M. I. (1998) · PubMed Central · Cited by 115
Over-the-Counter Analgesics in Older Adults
Roumie, C. L., & Griffin, M. R. (2004) · Drugs & Aging · doi:10.2165/00002512-200421080-00001 · Cited by 114
ISFM and AAFP Consensus Guidelines: Long-Term use of NSAIDs in Cats
Sparkes, A., Heiene, R., Lascelles, B. D. X., Malík, R., Sampietro, L. R., Robertson, S. A., Scherk, M. A., & Taylor, P. M. (2010) · Journal of Feline Medicine and Surgery · doi:10.1016/j.jfms.2010.05.004 · Cited by 112
Möller, B., Pruijm, M. T., Adler, S., Scherer, A., Villiger, P. M., & Finckh, A. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204078 · Cited by 113
Regular use of analgesics is a risk factor for renal cell carcinoma
Gago-Domínguez, M., Yuan, J.-M., Castelao, J. E., Ross, R. K., & Yu, M. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690728 · Cited by 110
“Aspirin, non-aspirin NSAID, phenacetin and ac minophen used alone or in combination have been reported associated with chronic nephropathy, chronic renal failure or stage renal disease in several case–control studies (Pomme 1989; Sandler et al, 1989; 1991; Perneger et al, 1994).”
BackgroundRisk of end-stage renal disease associated with gout: a nationwide population study
Yu, K., Kuo, C., Luo, S., See, L., Chou, I., Chang, H.-C., & Chiou, M. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3806 · Cited by 108
“Moreover, patients with gout are more likely to have received non-steroid anti-inflammatory drugs, which have been documented to be a risk factor for ESRD [34].”
BackgroundPaulose‐Ram, R., Hirsch, R., Dillon, C. F., & Gu, Q. (2004) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.983 · Cited by 99
(2008) · Arthritis Care & Research · doi:10.1002/art.23929 · Cited by 98
Lai, M., Lai, J., Chen, P., Hsieh, S.-C., Hu, F.-C., & Wang, J. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.10.055 · Cited by 96
Ejaz, P., Bhojani, K. S., & Joshi, V. (2004) · PubMed · Cited by 93
Agodoa, L. Y. C., & Eggers, P. W. (2007) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2007.00350.x · Cited by 91
Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids for The Management of Canine Osteoarthritis
Johnston, S. A., & Budsberg, S. C. (1997) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(97)50083-0 · Cited by 91
Ferrell, B. A. (2003) · Springer eBooks · doi:10.1007/0-387-22621-4_28 · Cited by 90
A review of the toxicology presence and removal of ketoprofen through adsorption technology
Georgin, J., Franco, D. S. P., Martinello, K. D. B., Lima, E. C., & Silva, L. F. O. (2022) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2022.107798 · Cited by 89
Use of Nonsteroidal Anti-Inflammatory Drugs Following Exercise-Induced Muscle Injury
Lanier, A. B. (2003) · Sports Medicine · doi:10.2165/00007256-200333030-00002 · Cited by 88
Hsu, P.-C., Tsai, Y., Lai, J., Wu, C., Lin, S., & Huang, C. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.08.029 · Cited by 86
Nonsteroidal anti-inflammatory drugs: Practical and theoretical considerations in their selection
Polisson, R. P. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)89544-7 · Cited by 86
Analgesic use and chronic renal failure: A critical review of the epidemiologic literature
McLaughlin, J. K., Lipworth, L. P., Chow, W., & Blot, W. J. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00043.x · Cited by 85
“For instance, in a study conducted in the Mid-Atlantic region of the United States [16], the majority of the cases were male (58%) and black (54%), while the controls were predominantly female (65%) and white (86%).”
BackgroundInfluentialA Benefit-Risk Assessment of Caffeine as an Analgesic Adjuvant
Zhang, W. (2001) · Drug Safety · doi:10.2165/00002018-200124150-00004 · Cited by 85
Ingrasciotta, Y., Sultana, J., Giorgianni, F., Fontana, A., Santangelo, A., Tari, D. U., Santoro, D., Arcoraci, V., Perrotta, M., Ibáñez, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122899 · Cited by 84
“NSAIDs were found to be associated with an increase in the risk of CKD in two case-control studies [38, 39], but not in three cohort studies in healthy subjects [23–25, 40].”
ResultAnalgesic use and the risk for progression of chronic kidney disease
Kuo, H., Tsai, S., Tiao, M., Liu, Y., Lee, I., & Yang, C. (2010) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1962 · Cited by 83
Cabassi, A., Tedeschi, S., Perlini, S., Verzicco, I., Volpi, R., Gonzi, G., & Canale, S. D. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319848105 · Cited by 86
“The latter, coupled with age-related progressive decline in renal function makes the elderly more vulnerable to the noxious effects of many drugs, especially NSAIDs.6 Their potential toxicity is further aggravated by the fact that their use is often inappropriate, and without real control by doctors.”
BackgroundInfluentialMa, S., Song, W., Xu, Y., Si, X., Zhang, D., Lv, S., Yang, C., Ma, L., Tang, Z., & Chen, X. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119676 · Cited by 81
The clinical spectrum of tubulointerstitial nephritis
Rastegar, A., & Kashgarian, M. J. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00001.x · Cited by 80
“Control groups were drawn from hospitalized patients [18], a normal population [21, 45, 46], outpatient clinic patients [20], and both normal populations as well as patients with renal failure without papillary necrosis [43].”
BackgroundMethodInfluentialAnalgesic use and change in kidney function in apparently healthy men
Kurth, T., Glynn, R. J., Walker, A. M., Rexrode, K. M., Buring, J. E., Stampfer, M. J., Hennekens, C. H., & Gaziano, J. M. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00647-4 · Cited by 80
Rohla, M., Weiss, T. W., Pecen, L., Patti, G., Siller-Matula, J. M., Schnabel, R. B., SCHILLING, R. J., Kotecha, D., Lucerna, M., Huber, K., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-022478 · Cited by 84
Lai, M., Lai, J., Chen, P., Tseng, W., CHEN, Y., Hwang, J., & WANG, J. (2008) · Nephrology · doi:10.1111/j.1440-1797.2008.01061.x · Cited by 78
“The crude analysis in Table 1 and crude HR in Table 2 appeared to have increased risks of CKD for NSAIDs and acetaminophen with dose–response associations, compatible with previous reports indicating the potential nephrotoxic effects of NSAIDs and acetaminophen.(34,35) However, there was multi-collinearity among hyper…”
ResultBalancing benefits and harms: the example of non-steroidal anti-inflammatory drugs
Dieppe, P. A., Bartlett, C., Davey, P., Doyal, L., & Ebrahim, S. B. J. (2004) · BMJ · doi:10.1136/bmj.329.7456.31 · Cited by 78
Chrysohoou, C. A., Panagiotakos, D. B., Pitsavos, C. E., Skoumas, J., Zeimbekis, A., Kastorini, C.-M., & Stefanadis, C. (2009) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2009.08.006 · Cited by 77
Complementary and alternative medicine in early-stage breast cancer
Tagliaferri, M. A., Cohen, I., & Tripathy, D. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90049-1 · Cited by 76
Rousseau, P. C. (1995) · Disease-a-Month · doi:10.1016/s0011-5029(95)90103-5 · Cited by 77
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial.
Pavličević, I., Kuzmanić, M., Rumboldt, M., & Rumboldt, Z. (2008) · PubMed · Cited by 75
Nelson, D. A., Marks, E. S., Deuster, P. A., O’Connor, F. G., & Kurina, L. M. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.7896 · Cited by 74
(1998) · JAMA · doi:10.1001/jama.280.18.1636 · Cited by 74
Elseviers, M. M., Schepper, A. D., Corthouts, R., Bosmans, J., Cosyn, L., Lins, R. L., Lornoy, W., Matthys, E. G. J., Roose, R., D, V. C., et al. (1995) · Kidney International · doi:10.1038/ki.1995.416 · Cited by 72
Pahor, M., Guralnik, J. M., Wan, J. Y., Ferrucci, L., Penninx, B. W. J. H., Lyles, A., Ling, S. M., & Fried, L. P. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.6.930 · Cited by 71
Patterns of Opioid Analgesic Prescription Among Patients with Osteoarthritis
Dominick, K. L., Bosworth, H. B., Dudley, T. K., Waters, S. J., Campbell, L. C., & Keefe, F. J. (2004) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/j354v18n01_03 · Cited by 69
Molecular pathways driving omeprazole nephrotoxicity
Fontecha‐Barriuso, M., Martín‐Sánchez, D., Martinez-Moreno, J. M., Cárdenas-Villacrés, D. E., Carrasco, S., Sánchez-Niño, M. D., Ruiz‐Ortega, M., Ortíz, A., & Sanz, A. B. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101464 · Cited by 70
Launay‐Vacher, V., Karie, S., Fau, J., Izzedine, H., & Deray, G. (2005) · Journal of Pain · doi:10.1016/j.jpain.2004.11.009 · Cited by 68
Recreational drug use: A neglected risk factor for end-stage renal disease
Perneger, T., Klag, M. J., & Whelton, P. K. (2001) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2001.25181 · Cited by 68
Self-citationPharmacological Treatments for Persistent Non-Malignant Pain in Older Persons
Nikolaus, T., & Zeyfang, A. (2004) · Drugs & Aging · doi:10.2165/00002512-200421010-00003 · Cited by 66
Acetaminophen, aspirin and progression of advanced chronic kidney disease
Evans, M., Fored, C. M., Bellocco, R., Fitzmaurice, G. M., Fryzek, J. P., McLaughlin, J. K., Nyrén, O., & Elinder, C. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn745 · Cited by 66
A Review of Epidemiologic Studies of Nonnarcotic Analgesics and Chronic Renal Disease
Delzell, E., & Shapiro, S. (1998) · Medicine · doi:10.1097/00005792-199803000-00003 · Cited by 66
Over-the-Counter Analgesic Use
Broe, M. E. D., & Elseviers, M. M. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008101097 · Cited by 64
Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms
Kennon‐McGill, S., & McGill, M. R. (2017) · Journal of Clinical and Translational Research · doi:10.18053/jctres.03.201703.005 · Cited by 64
“cause analgesic nephropathy [107,108], although that has been questioned by findings from very large studies of “healthy” individuals who regularly use over-the-counter analgesics including APAP [108].”
BackgroundRelationship between nonphenacetin combined analgesics and nephropathy: A review
Feinstein, A. R., Heinemann, L. A. J., Curhan, G. C., Delzell, E., DeSchepper, P. J., Fox, J. M., Graf, H., Luft, F. C., Michielsen, P., Mihatsch, M. J., et al. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00410.x · Cited by 63
Metadata
- Authors
- Perneger, T. V., Whelton, P. K., & Klag, M. J.
- Affiliations
- University of Geneva (CH)
- Johns Hopkins University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1994-12-22
- Volume
- 331
- Issue
- 25
- Pages
- 1675-1679
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320758398
- Cited by
- 484
- References
- 15
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 18 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 21 · 2019: 19 · 2018: 11 · 2017: 10 · 2016: 16 · 2015: 17 · 2014: 17 · 2013: 20 · 2012: 20
- FWCI
- 20.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agency for Healthcare Research and Quality (R03-HS06978-01)
- National Center for Research Resources (5MOIRR00722, RR 00035)
- Topics
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- end-stage renal disease, renal failure, paracetamol, aspirin, nonsteroidal anti-inflammatory drugs, analgesic use, dose-response relationship, attributable risk, drug-induced nephrotoxicity
- MeSH terms
- Acetaminophen, Adult, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Drug Utilization, Female, Humans, Kidney Failure, Chronic, Male, Middle Aged, Risk Factors, Causality, Confidence Intervals, Odds Ratio, Case-Control Studies
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