The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass
Abstract
BACKGROUND: Deep hypothermia with either total circulatory arrest or low-flow cardiopulmonary bypass is used to support vital organs during heart surgery in infants. We compared the developmental and neurologic sequelae of these two strategies one year after surgery. METHODS: Infants with D-transposition of the great arteries who underwent an arterial-switch operation were randomly assigned to a method of support consisting predominantly of circulatory arrest or a method consisting predominantly of low-flow bypass. Developmental and neurologic evaluations and magnetic resonance imaging (MRI) were performed at one year of age. RESULTS: Of the 171 patients enrolled in the study, 155 were evaluated. After adjustment for the presence or absence of a ventricular septal defect, the infants assigned to circulatory arrest, as compared with those assigned to low-flow bypass, had a lower mean score on the Psychomotor Development Index of the Bayley Scales of Infant Development (a 6.5-point deficit, P = 0.01) and a higher proportion had scores < or = 80 (i.e., 2 SD or more below the population mean) (27 percent vs. 12 percent, P = 0.02). The score on the Psychomotor Development Index was inversely related to the duration of circulatory arrest (P = 0.02). The risk of neurologic abnormalities increased with the duration of circulatory arrest (P = 0.04). The method of support was not associated with the prevalence of abnormalities on MRI scans of the brain, scores on the Mental Development Index of the Bayley Scale, or scores on a test of visual-recognition memory. Perioperative electroencephalographic seizure activity was associated with lower scores on the Psychomotor Development Index (P = 0.002) and an increased likelihood of abnormalities on MRI scans of the brain (P < 0.001). CONCLUSIONS: Heart surgery performed with circulatory arrest as the predominant support strategy is associated with a higher risk of delayed motor development and neurologic abnormalities at the age of one year than is surgery with low-flow bypass as the predominant support strategy.
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Cites
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,988
Manual for the Bayley Scales of Infant Development
Bayley, N. (1969) · Medical Entomology and Zoology · Cited by 1,328
Newburger, J. W., Jonas, R. A., Wernovsky, G., Wypij, D., Hickey, P. R., Kuban, K., Farrell, D. M., Holmes, G. L., Helmers, S. L., Constantinou, J., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310073291501 · Cited by 702
Self-citationEpileptogenic effect of hypoxia in the immature rodent brain
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The neurological assessment of the preterm and full-term newborn infant
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Kirklin, J. W., & Barratt‐Boyes, B. G. (1986) · Medical Entomology and Zoology · Cited by 196
Age‐Dependent Changes in Long‐Term Seizure Susceptibility and Behavior After Hypoxia in Rats
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Self-citationAcquired Neuropathologic Lesions Associated With the Hypoplastic Left Heart Syndrome
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The effect of hypothermic circulatory arrest time on cerebral function, morphology, and biochemistry
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Cited by
Marino, B. S., Lipkin, P. H., Newburger, J. W., Peacock, G., Gerdes, M., Gaynor, J. W., Mussatto, K. A., Uzark, K., Goldberg, C. S., Johnson, W. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318265ee8a · Cited by 1,608
Self-citationWernovsky, G., Wypij, D., Jonas, R. A., Mayer, J. E., Hanley, F. L., Hickey, P. R., Walsh, A. Z., Chang, A. C., Castañeda, A. R., Newburger, J. W., et al. (1995) · Circulation · doi:10.1161/01.cir.92.8.2226 · Cited by 1,010
Self-citationSun, L. S., Li, G., Miller, T. L. K., Salorio, C., Byrne, M. W., Bellinger, D. C., Ing, C., Park, R., Radcliffe, J., Hays, S. R., et al. (2016) · JAMA · doi:10.1001/jama.2016.6967 · Cited by 949
Self-citationAbnormal brain development in newborns with congenital heart disease
Miller, S. P., McQuillen, P. S., Hamrick, S., Xu, D., Glidden, D. V., Charlton, N., Karl, T., Azakie, A., Ferriero, D. M., Barkovich, A. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067393 · Cited by 860
Bellinger, D. C., Wypij, D., duPlessis, A. J., Rappaport, L. A., Jonas, R. A., Wernovsky, G., & Newburger, J. W. (2003) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(03)00711-6 · Cited by 681
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Metadata
- Authors
- Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C. K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., Walsh, A. Z., Helmers, S. L., Constantinou, J. E., Carrazana, E. J., Mayer, J. E., Hanley, F. L., Castaneda, A. R., Ware, J. H., & Newburger, J. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-03-02
- Volume
- 332
- Issue
- 9
- Pages
- 549-555
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324991405
- Cited by
- 802
- References
- 26
- FWCI
- 28.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C. K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., Walsh, A. Z., Helmers, S. L., Constantinou, J. E., Carrazana, E. J., Mayer, J. E., Hanley, F. L., Castaneda, A. R., Ware, J. H., & Newburger, J. W. (1995). Developmental and Neurologic Status of Children after Heart Surgery with Hypothermic Circulatory Arrest or Low-Flow Cardiopulmonary Bypass. New England Journal of Medicine. https://doi.org/10.1056/nejm199503023320901
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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