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Acquired Neuropathologic Lesions Associated With the Hypoplastic Left Heart Syndrome
Abstract
This study details the type, frequency, clinical presentation, and etiologic associations of acquired brain lesions in 40 infants with the hypoplastic left heart syndrome encountered during a 52-month interval. Detailed postmortem neuropathologic examinations showed that 55% of the infants were free of acquired brain lesions. However, the other 45% had combinations of hypoxic-ischemic lesions and intracranial hemorrhage. Central nervous system perfusion and glucose-oxygen delivery appeared to be important factors in the occurrence of hypoxic-ischemic lesions or intracranial hemorrhage, whereas acidosis and hypercarbia were not. Cerebral necrosis may be a predisposing factor for a major intracranial hemorrhage. A duration of cardiopulmonary bypass with hypothermic total circulatory arrest longer than 40 minutes was associated with a higher incidence of acquired neuropathology. These results indicate that the majority of infants with hypoplastic left heart syndorme are free of acquired neuropathology and suggest practical ways to reduce the risks in the others.
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Cited by
Bellinger, D. C., Jonas, R. A., Rappaport, L. A., Wypij, D., Wernovsky, G., Kuban, K. C. K., Barnes, P. D., Holmes, G. L., Hickey, P. R., Strand, R. D., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320901 · Cited by 802
An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
Mahle, W. T., Tavani, F., Zimmerman, R. A., Nicolson, S. C., Galli, K. K., Gaynor, J. W., Clancy, R. R., Montenegro, L. M., Spray, T. L., Chiavacci, R. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000032908.33237.b1 · Cited by 541
Self-citationMahle, W. T., Clancy, R. R., McGaurn, S. P., Goin, J. E., & Clark, B. J. (2001) · Pediatrics · doi:10.1542/peds.107.6.1277 · Cited by 375
Self-citationDonofrio, M. T., Bremer, Y. A., Schieken, R. M., Gennings, C., Morton, L. D., Eidem, B. W., Cetta, F., Falkensammer, C. B., Huhta, J. C., & Kleinman, C. S. (2003) · Pediatric Cardiology · doi:10.1007/s00246-002-0404-0 · Cited by 364
Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects
Licht, D. J., Wang, J., Silvestre, D. W., Nicolson, S. C., Montenegro, L. M., Wernovsky, G., Tabbutt, S., Durning, S. M., Shera, D. M., Gaynor, J. W., et al. (2004) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2004.07.022 · Cited by 332
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Metadata
- Authors
- Glauser, T. A., Rorke, L. B., Weinberg, P. M., & Clancy, R. R.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 1990-06-01
- Volume
- 85
- Issue
- 6
- Pages
- 991-1000
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W1636200806
- Cited by
- 183
- References
- 0
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acquired Neuropathologic Lesions Associated With the Hypoplastic Left Heart Syndrome. https://app.cochat.ai/papers/10.1542/peds.85.6.991
- The paper
- Glauser, T. A., Rorke, L. B., Weinberg, P. M., & Clancy, R. R. (1990). Acquired Neuropathologic Lesions Associated With the Hypoplastic Left Heart Syndrome. Pediatrics. https://doi.org/10.1542/peds.85.6.991
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