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Inhaled Glucocorticoids for Asthma
Abstract
Glucocorticoids are the most effective therapy available for patients with asthma. They may be administered either orally or, much more safely, by inhalation. With the recognition that airway inflammation is present even in patients with mild asthma, therapy with inhaled glucocorticoids is now recommended at a much earlier stage.1 However, despite their proved efficacy in the treatment of asthma, enthusiasm for their use has been tempered by concern about systemic side effects. Because of this concern, less effective therapies are often preferred, particularly for children.Mechanism of ActionMolecular MechanismsInhaled glucocorticoids are highly lipophilic. They rapidly enter airway cells, . . .
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Cited by
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
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Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933
Woodruff, P. G., Boushey, H. A., Dolganov, G. M., Barker, C. S., Yang, Y. H., Donnelly, S., Ellwanger, A., Sidhu, S. S., Dao-Pick, T. P., Pantoja, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707413104 · Cited by 828
McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805
Drazen, J. M., Yandava, C. N., Dubé, L., Szczerback, N., Hippensteel, R., Pillari, A., Israel, E., Schork, N., Silverman, E. S., Katz, D. A., et al. (1999) · Nature Genetics · doi:10.1038/9680 · Cited by 560
Metadata
- Authors
- Barnes, P. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-03-30
- Volume
- 332
- Issue
- 13
- Pages
- 868-875
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2328990695
- Cited by
- 629
- References
- 0
- FWCI
- 34.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barnes, P. J. (1995). Inhaled Glucocorticoids for Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm199503303321307
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
