Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways
Abstract
I. Introduction II. Nuclear Factor-κB (NF-κB) A. Introduction B. NF-κB is a dimeric transcription factor C. The regulatory subunit IκB is an inhibitor of NF-κB D. Activation and function of NF-κB E. The transcription factor NF-κB interacts with multiple transcription factors and transcriptional co-factors F. Transgenic animals suggest a complex role for NF-κB family members in immunity and development III. Steroid Hormones/Receptors: Glucocorticoids and the Glucocorticoid Receptor (GR) A. General background B. Glucocorticoid mechanism of action: the GR C. Glucocorticoid physiology D. GR/NF-κB interactions E. GR interacts with other transcription factors and transcriptional cofactors IV. NF-κB and GR Antagonism: Physiological Significance? V. Interactions Between NF-κB and Other Steroid Hormone Receptors A. Androgen receptor (AR) B. Estrogen receptor (ER) C. Progesterone receptor (PR) VI. Summary/Conclusions
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NF-κB directly interacts with GR in the nucleus through protein-protein interactions, causing mutual repression of both GR and NF-κB function.
“NF-κB has been found to directly interact with GR in the nucleus through protein-protein interactions, causing mutual repression of both GR and NF-κB function.67”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [67]
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383 · see citing works
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553 · see citing works
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503 · see citing works
Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819 · see citing works
Self-citationInsulin-like Growth Factor Binding Protein-1: Recent Findings and New Directions
Lee, P. D. K., Giudice, L. C., Conover, C. A., & Powell, D. R. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-216-44182 · Cited by 523 · see citing works
A corticosteroid receptor in neuronal membranes
Orchinik, M., Murray, T. F., & Moore, F. L. (1991) · Science · doi:10.1126/science.2063198 · Cited by 523 · see citing works
The Carboxyl-terminal Region of STAT3 Controls Gene Induction by the Mouse Haptoglobin Promoter
Kim, H., & Baumann, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14571 · Cited by 68 · see citing works
Flagged first, then by citations
Cited by
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Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370 · see citing works
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149 · see citing works
Self-citationCytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
The complex role of estrogens in inflammation
Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950 · see citing works
Coutinho, A. E., & Chapman, K. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.04.005 · Cited by 1,815 · see citing works
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works
Sex hormones and the immune response in humans
Bouman, A., Heineman, M. J., & Faas, M. M. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi008 · Cited by 1,131 · see citing works
Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952 · see citing works
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00817-6 · Cited by 818 · see citing works
The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
Pavlov, V. A., Wang, H., Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Molecular Medicine · doi:10.1007/bf03402177 · Cited by 772 · see citing works
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688 · see citing works
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Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676 · see citing works
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Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647 · see citing works
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
The human glucocorticoid receptor: molecular basis of biologic function
Nicolaides, N. C., Galata, Z., Kino, T., Chrousos, G. P., & Charmandari, E. (2010) · Steroids · doi:10.1016/j.steroids.2009.09.002 · Cited by 436 · see citing works
Mechanisms of glucocorticoid receptor signaling during inflammation
Smoak, K. A., & Cidlowski, J. A. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.06.010 · Cited by 420 · see citing works
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Meduri, G. U., Tolley, E. A., Chrousos, G. P., & Stentz, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2106014 · Cited by 265 · see citing works
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Bhattacharyya, S., Brown, D. E., Brewer, J. A., Vogt, S. K., & Muglia, L. J. (2007) · Blood · doi:10.1182/blood-2006-10-048215 · Cited by 249 · see citing works
Mechanisms of sex disparities in influenza pathogenesis
Klein, S. L., Hodgson, A., & Robinson, D. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811427 · Cited by 219 · see citing works
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis
González-Ramos, R., Van Langendonckt, A., Defrère, S., Lousse, J.-C., Colette, S., Devoto, L., & Donnez, J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.01.013 · Cited by 179 · see citing works
Deroo, B. J., Rentsch, C., Sampath, S., Young, J., DeFranco, D. B., & Archer, T. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4113-4123.2002 · Cited by 164 · see citing works
Wong, S. C., Dobie, R., Altowati, M. A., Werther, G. A., Farquharson, C., & Ahmed, S. F. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1026 · Cited by 163 · see citing works
Dias, G. P., Cavegn, N., Nix, A., do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S. A., Nardi, A. E., Gardino, P. F., & Thuret, S. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/541971 · Cited by 153 · see citing works
Arloth, J., Bogdan, R., Weber, P., Frishman, G., Menke, A., Wagner, K. V., Balsevich, G., Schmidt, M. V., Karbalai, N., Czamara, D., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.034 · Cited by 142 · see citing works
Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.003 · Cited by 150 · see citing works
Rohleder, N. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.015 · Cited by 136 · see citing works
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works
Wang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128 · see citing works
MacPherson, A., Dinkel, K., & Sapolsky, R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.02.021 · Cited by 120 · see citing works
Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects
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A Role for STAT5 in the Pathogenesis of IL-2-Induced Glucocorticoid Resistance
Goleva, E., Kisich, K. O., & Leung, D. Y. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5934 · Cited by 113 · see citing works
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Murphy, S. H., Suzuki, K., Downes, M., Welch, G. L., De Jesus, P., Miraglia, L. J., Orth, A. P., Chanda, S. K., Evans, R. M., & Verma, I. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114420108 · Cited by 93 · see citing works
Nasu, K., Nishida, M., Kawano, Y., Tsuno, A., Abe, W., Yuge, A., Takai, N., & Narahara, H. (2011) · Reproductive Sciences · doi:10.1177/1933719110392059 · Cited by 73 · see citing works
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia
Barrientos, R. M., Thompson, V. M., Kitt, M. M., Amat, J., Hale, M. W., Frank, M. G., Crysdale, N. Y., Stamper, C. E., Hennessey, P. A., Watkins, L. R., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.003 · Cited by 70 · see citing works
Relevance of chronic stress and the two faces of microglia in Parkinson's disease
Herrera, A. J., Espinosa-Oliva, A. M., Carrillo-Jiménez, A., Oliva-Martín, M. J., García-Revilla, J., García-Quintanilla, A., de Pablos, R. M., & Venero, J. L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00312 · Cited by 42 · see citing works
Prado, C., de Paz, B., Gómez, J., López, P., Rodríguez-Carrio, J., & Suárez, A. (2011) · Rheumatology · doi:10.1093/rheumatology/ker227 · Cited by 33 · see citing works
Rohleder, N., Otto, B., Wolf, J. M., Klose, J., Kirschbaum, C., Enck, P., & Klosterhalfen, S. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.07.004 · Cited by 31 · see citing works
The helix 1–3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones
Cluning, C., Ward, B. K., Rea, S. L., Arulpragasam, A., Fuller, P. J., & Ratajczak, T. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1023 · Cited by 26 · see citing works
Peschel, W., Kump, A., & Prieto, J. M. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01349.x · Cited by 24 · see citing works
- Authors
- McKay, L. I., & Cidlowski, J. A.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Cidlowski, John A.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1999-08-01
- Volume
- 20
- Issue
- 4
- Pages
- 435-459
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1972368286
- Cited by
- 805
- References
- 9
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 15 · 2021: 22 · 2020: 15 · 2019: 15 · 2018: 19 · 2017: 24 · 2016: 25 · 2015: 24 · 2014: 26 · 2013: 30 · 2012: 31
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, glucocorticoid receptor, steroid hormone receptors, transcription factor interaction, IκB, inflammation, immunity, androgen receptor, estrogen receptor, progesterone receptor, transcriptional cofactors
- MeSH terms
- Animals, DNA-Binding Proteins, Humans, Inflammation, Receptors, Androgen, Receptors, Estrogen, Receptors, Glucocorticoid, Receptors, Progesterone, Signal Transduction, NF-kappa B, Receptor Cross-Talk, I-kappa B Proteins, Animals, Genetically Modified, Mice
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