Cited by 805NF-κB Signaling PathwaysEstrogen and related hormone effectsSignaling Pathways in Disease

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

McKay, Lorraine I., Cidlowski, John A.·1999·Endocrine Reviews

Abstract

I. Introduction II. Nuclear Factor-κB (NF-κB) A. Introduction B. NF-κB is a dimeric transcription factor C. The regulatory subunit IκB is an inhibitor of NF-κB D. Activation and function of NF-κB E. The transcription factor NF-κB interacts with multiple transcription factors and transcriptional co-factors F. Transgenic animals suggest a complex role for NF-κB family members in immunity and development III. Steroid Hormones/Receptors: Glucocorticoids and the Glucocorticoid Receptor (GR) A. General background B. Glucocorticoid mechanism of action: the GR C. Glucocorticoid physiology D. GR/NF-κB interactions E. GR interacts with other transcription factors and transcriptional cofactors IV. NF-κB and GR Antagonism: Physiological Significance? V. Interactions Between NF-κB and Other Steroid Hormone Receptors A. Androgen receptor (AR) B. Estrogen receptor (ER) C. Progesterone receptor (PR) VI. Summary/Conclusions

Integrity signals

Registry

Crossref · 10.1210/edrv.20.4.0375

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9 of 9 references verified0 citation errors · 0 not checkable

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  • NF-κB directly interacts with GR in the nucleus through protein-protein interactions, causing mutual repression of both GR and NF-κB function.

    “NF-κB has been found to directly interact with GR in the nucleus through protein-protein interactions, causing mutual repression of both GR and NF-κB function.67”

    From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [67]

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Authors
McKay, L. I., & Cidlowski, J. A.
Affiliations
National Institutes of Health (US)
Venue
Endocrine Reviews
Published
1999-08-01
Volume
20
Issue
4
Pages
435-459
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W1972368286
Cited by
805
References
9
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 15 · 2021: 22 · 2020: 15 · 2019: 15 · 2018: 19 · 2017: 24 · 2016: 25 · 2015: 24 · 2014: 26 · 2013: 30 · 2012: 31
FWCI
3.27
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
NF-κB, glucocorticoid receptor, steroid hormone receptors, transcription factor interaction, IκB, inflammation, immunity, androgen receptor, estrogen receptor, progesterone receptor, transcriptional cofactors
MeSH terms
Animals, DNA-Binding Proteins, Humans, Inflammation, Receptors, Androgen, Receptors, Estrogen, Receptors, Glucocorticoid, Receptors, Progesterone, Signal Transduction, NF-kappa B, Receptor Cross-Talk, I-kappa B Proteins, Animals, Genetically Modified, Mice

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