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Regulation of Cell Volume in Health and Disease
Abstract
Maintenance of a constant volume in the face of extracellular and intracellular osmotic perturbations is a critical problem faced by all cells. Most cells respond to swelling or shrinkage by activating specific metabolic or membrane-transport processes that return cell volume to its normal resting state. These processes are essential for the normal function and survival of cells. This article will outline the cellular and molecular events underlying cell-volume homeostasis and discuss their relevance to medical practice. Fundamentals of Cell-Volume Regulation Meeting Osmotic Challenges Water is in thermodynamic equilibrium across the plasma membrane. In other words, the osmotic concentrations of cytoplasmic . . .
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Cited by
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Hillered, L., Vespa, P. M., & Hovda, D. A. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.3 · Cited by 365
Brain swelling after dialysis: old urea or new osmoles
Silver, S. M., Sterns, R. H., & Halperin, M. L. (1996) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(96)90124-9 · Cited by 162
Cho, K. H., Han, E. Y., Lee, S. A., Park, H., Lee, C., & IM, S. H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00111 · Cited by 29
Metadata
- Authors
- McManus, M. L., Churchwell, K. B., & Strange, K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1995-11-09
- Volume
- 333
- Issue
- 19
- Pages
- 1260-1267
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2338871610
- Cited by
- 441
- References
- 0
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- McManus, M. L., Churchwell, K. B., & Strange, K. (1995). Regulation of Cell Volume in Health and Disease. New England Journal of Medicine. https://doi.org/10.1056/nejm199511093331906
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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