The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Atrophic Gastritis and Helicobacter pylori Infection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication
Open accessAbstract
BACKGROUND: Helicobacter pylori infection plays an important part in the development of atrophic gastritis and intestinal metaplasia, conditions that predispose patients gastric cancer. Profound suppression of gastric acid is associated with increased severity of gastritis caused by H. pylori, but it is not known whether acid suppression increases the risk of atrophic gastritis. METHODS: We studied patients from two separate cohorts who were being treated for reflux esophagitis: 72 patients treated with fundoplication in Sweden and 105 treated with omeprazole (20 to 40 mg once daily) in the Netherlands. In both cohorts, the patients were followed for an average of five years (range, three to eight). After fundoplication, the patients did not receive acid-suppressive therapy. The presence of H. pylori was assessed at the first visit by histologic evaluation in the fundoplication group and by histologic and serologic evaluation in the omeprazole group. The patients were not treated for H. pylori infection. Before treatment and during follow-up, the patients underwent repeated gastroscopy, with biopsy sampling for histologic evaluation. RESULTS: Among the patients treated with fundoplication, atrophic gastritis did not develop in any of the 31 who were infected with H. pylori at base line or the 41 who were not infected; 1 patient infected with H. pylori had atrophic gastritis before treatment that persisted after treatment. Among the patients treated with omeprazole, none of whom had atrophic gastritis at base line, atrophic gastritis developed in 18 of the 59 infected with H. pylori(P<0.001) and 2 of the 46 who were not infected (P=0.62). CONCLUSIONS: Patients with reflux esophagitis and H. pylori infection who are treated with omeprazole are at increased risk of atrophic gastritis.
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Cites
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Self-citationLong-Term Treatment with Omeprazole for Refractory Reflux Esophagitis: Efficacy and Safety
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Cited by
Helicobacter pylori Infection and the Development of Gastric Cancer
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Self-citationInterleukin-1 polymorphisms associated with increased risk of gastric cancer
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Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease
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Metadata
- Authors
- Kuipers, E. J., Lundell, L., Klinkenberg-Knol, E. C., Havu, N., Festen, H. P. M., Liedman, B., Lamers, C. B. H. W., Jansen, J. B. M. J., Dalenbäck, J., Snel, P., Nelis, G. F., & Meuwissen, S. G. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-04-18
- Volume
- 334
- Issue
- 16
- Pages
- 1018-1022
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2076694998
- Cited by
- 769
- References
- 21
- FWCI
- 61.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuipers, E. J., Lundell, L., Klinkenberg-Knol, E. C., Havu, N., Festen, H. P. M., Liedman, B., Lamers, C. B. H. W., Jansen, J. B. M. J., Dalenbäck, J., Snel, P., Nelis, G. F., & Meuwissen, S. G. M. (1996). Atrophic Gastritis and Helicobacter pylori Infection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication. New England Journal of Medicine. https://doi.org/10.1056/nejm199604183341603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
