Pathogenesis of Helicobacter pylori Infection

Kusters, Johannes G.; van Vliet, Arnoud H. M.; Kuipers, Ernst J.

doi:10.1128/cmr.00054-05

Cited by 2,526Helicobacter pylori-related gastroenterology studiesGastrointestinal motility and disordersSalmonella and Campylobacter epidemiology

Pathogenesis of Helicobacter pylori Infection

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Kusters, Johannes G., van Vliet, Arnoud H. M., Kuipers, Ernst J.·2006·Clinical Microbiology Reviews

DOI 10.1128/cmr.00054-05PMC PMC1539101

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Abstract

SUMMARY: Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. Host immune gene polymorphisms and gastric acid secretion largely determine the bacterium's ability to colonize a specific gastric niche. Bacterial virulence factors such as the cytotoxin-associated gene pathogenicity island-encoded protein CagA and the vacuolating cytotoxin VacA aid in this colonization of the gastric mucosa and subsequently seem to modulate the host's immune system. This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori .

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H. pylori infection can lead to antrum-predominant gastritis, in which the oxyntic mucosa is not inflamed but a gastrin-driven increase in acid output occurs, along with the possible development of duodenal ulcer.
“H. pylori infection can lead to antrum-predominant gastritis, in which the oxyntic mucosa is not inflamed but a gastrin-driven increase in acid output occurs, along with the possible development of duodenal ulcer[67,68].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [67]

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Authors: Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J.
Affiliations: Erasmus MC (NL)
Department of Gastroenterology and Hepatology, Erasmus MC—University Medical Center, Rotterdam, The Netherlands
ORCID: Kusters, Johannes G.
Kuipers, Ernst J.
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2006-07
Volume: 19
Issue: 3
Pages: 449-490
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.00054-05
PMC: PMC1539101
OpenAlex: W2153354382
Cited by: 2,526
References: 732
Citations by year: 2026: 93 · 2025: 127 · 2024: 117 · 2023: 119 · 2022: 133 · 2021: 180 · 2020: 174 · 2019: 153 · 2018: 129 · 2017: 144 · 2016: 137 · 2015: 140 · 2014: 172 · 2013: 140 · 2012: 97
FWCI: 15.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords: Helicobacter pylori, pathogenesis, bacterial colonization, chronic active gastritis, peptic ulcer, gastric adenocarcinoma, gastric MALT lymphoma, host-pathogen interaction, gastric acid secretion, CagA, VacA, virulence factors
MeSH terms: Animals, Gastritis, Guinea Pigs, Humans, Peptic Ulcer, Stomach Neoplasms, Helicobacter pylori, Helicobacter Infections, Virulence Factors, Mice

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Pathogenesis of Helicobacter pylori Infection

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