The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Theophylline in Asthma
Abstract
Theophylline has been a popular medication for asthma for over 50 years. However, the introduction of newer pharmacologic agents, concern about the toxicity of theophylline, and recommendations in widely disseminated guidelines have recently contributed to its decreased use. In this review we reassess the role of theophylline in the pharmacotherapy of asthma and specifically address three pivotal questions: What are the data justifying its continued use? What are its risks? What is its role in the treatment of patients with asthma?HistoryAlthough first used as intravenous therapy for acute asthma1 and then as an oral medication in fixed doses . . .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Greening, A. P., Ind, P. W., Northfield, M., & Shaw, G. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92996-3 · Cited by 972
Inhaled Glucocorticoids for Asthma
Barnes, P. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503303321307 · Cited by 629
Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline
Jenne, J. W., Wyze, E., Rood, F. S., & MacDonald, F. M. (1972) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1972133349 · Cited by 496
Cheung, D., Timmers, M. C., Zwinderman, A. H., Bel, E. H., Dijkman, J. H., & Sterk, P. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210223271703 · Cited by 455
Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
Sullivan, P., Jaffar, Z., Page, C., Costello, J., Bekir, S., & Jeffery, P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90127-9 · Cited by 403
The Effect of Inhibition of 5-Lipoxygenase by Zileuton in Mild-to-Moderate Asthma
Israel, E., Rubin, P., Kemp, J. P., Grossman, J., Pierson, W., Siegel, S. C., Tinkelman, D., Murray, J. J., Busse, W., Segal, A. T., et al. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-11-199312010-00001 · Cited by 362
Spector, S. L., Smith, L. J., & Glass, M. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.3.8087328 · Cited by 341
Comparison of Patients' Compliance With Prescribed Oral and Inhaled Asthma Medications
Kelloway, J. S. (1994) · Archives of Internal Medicine · doi:10.1001/archinte.154.12.1349 · Cited by 334
Tinkelman, D. G., Reed, C. E., Nelson, H. S., & Offord, K. P. (1993) · Pediatrics · doi:10.1542/peds.92.1.64 · Cited by 297
Murciano, D., Aubier, M., Lecocguic, Y., & Pariente, R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408093110601 · Cited by 286
Cited by
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,994
International consensus on (ICON) pediatric asthma
Papadopoulos, N. G., Arakawa, H., Carlsen, K. ‐., Custovic, A., Gern, J., Lemanske, R., Le Souef, P., Mäkelä, M., Roberts, G., Wong, G., et al. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02865.x · Cited by 455
PDE4 inhibitors: current status
Spina, D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.307 · Cited by 340
Uncontrolled asthma: A review of the prevalence, disease burden and options for treatment
Peters, S. P., Ferguson, G., Deniz, Y., & Reisner, C. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.031 · Cited by 320
Impact of quality circles for improvement of asthma care: results of a randomized controlled trial
Schneider, A., Wensing, M., Biessecker, K., Quinzler, R., Kaufmann‐Kolle, P., & Szecsenyi, J. (2008) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2007.00827.x · Cited by 44
Metadata
- Authors
- Weinberger, M., & Hendeles, L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-05-23
- Volume
- 334
- Issue
- 21
- Pages
- 1380-1388
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2022935295
- Cited by
- 274
- References
- 54
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Theophylline in Asthma. https://app.cochat.ai/papers/10.1056/nejm199605233342107
- The paper
- Weinberger, M., & Hendeles, L. (1996). Theophylline in Asthma. New England Journal of Medicine. https://doi.org/10.1056/nejm199605233342107
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.