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Acute Renal Failure
Abstract
Acute renal failure is characterized by a deterioration of renal function over a period of hours to days, resulting in the failure of the kidney to excrete nitrogenous waste products and to maintain fluid and electrolyte homeostasis. In the past five decades, several important causes of acute renal failure and the pathophysiologic mechanisms that underlie renal dysfunction have come to be understood. In this article we highlight the epidemiology, general causes, and evaluation of acute renal failure in adults. We then expand on the pathophysiology of ischemic acute renal failure and discuss the rationale for both current and future therapies. . . .
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Citations
Cited by
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070716 · Cited by 2,921
Intrinsic Epithelial Cells Repair the Kidney after Injury
Humphreys, B. D., Valerius, M. T., Kobayashi, A., Mugford, J. W., Soeung, S., Duffield, J. S., McMahon, A. P., & Bonventre, J. V. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.01.014 · Cited by 868
Self-citationAlonso, A., Lau, J., Jaber, B. L., Weintraub, A., & Sarnak, M. J. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.09.009 · Cited by 345
Cellular and molecular pathways of renal repair after acute kidney injury
Kumar, S. (2018) · Kidney International · doi:10.1016/j.kint.2017.07.030 · Cited by 271
Metadata
- Authors
- Thadhani, R., Pascual, M., & Bonventre, J. V.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-05-30
- Volume
- 334
- Issue
- 22
- Pages
- 1448-1460
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4236514815
- Cited by
- 1,417
- References
- 0
- FWCI
- 28.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute Renal Failure. https://app.cochat.ai/papers/10.1056/nejm199605303342207
- The paper
- Thadhani, R., Pascual, M., & Bonventre, J. V. (1996). Acute Renal Failure. New England Journal of Medicine. https://doi.org/10.1056/nejm199605303342207
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
