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New Antiepileptic Drugs
Abstract
In the past two years, three new antiepileptic drugs — gabapentin, lamotrigine, and felbamate — have been approved for use in the United States. They are the first such drugs to be approved since valproic acid, in 1978. These three drugs and others now in use in Europe, Canada, or Japan or being tested in trials in the United States reflect the resurgence of interest in developing new drugs for the treatment of epilepsy. This article reviews the pharmacologic characteristics of these new drugs, indications for their use, side effects, and appropriate regimens.In many patients with epilepsy, seizures can . . .
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Citations
Cited by
Chiron, C., Marchand, M., Tran, A., Rey, E., d'Athis, P., Vincent, J., Dulac, O., & Pons, G. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03157-3 · Cited by 568
Stephen, L. J., Kwan, P., & Brodie, M. J. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.29000.x · Cited by 260
Self-citationPatients with Refractory Seizures
Devinsky, O. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905203402008 · Cited by 257
Antiepileptic drugs and the developing brain
Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. V. D., Turski, L., & Ikonomidou, C. (2006) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-005-5348-0 · Cited by 121
Adjunctive gabapentin treatment of bipolar disorder
Vieta, E., Martinez-Arán, A., Nieto, E., Colom, F., Reinares, M., Benabarre, A., & Gastó, C. (2000) · European Psychiatry · doi:10.1016/s0924-9338(00)00514-9 · Cited by 46
Metadata
- Authors
- Dichter, M. A., & Brodie, M. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-06-13
- Volume
- 334
- Issue
- 24
- Pages
- 1583-1590
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2322849220
- Cited by
- 340
- References
- 0
- FWCI
- 29.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dichter, M. A., & Brodie, M. J. (1996). New Antiepileptic Drugs. New England Journal of Medicine. https://doi.org/10.1056/nejm199606133342407
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
