Cited by 122Pharmacological Effects and Toxicity StudiesEpilepsy research and treatmentAnesthesia and Neurotoxicity Research

Antiepileptic drugs and the developing brain

Open access
Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. v.d., Turski, L., Ikonomidou, C.·2006·Cellular and Molecular Life Sciences CMLS

Abstract

Epilepsy is the most common neurological disorder in young humans. Antiepileptic drugs (AEDs) which are used to treat seizures in infants, children and pregnant women can cause cognitive impairment, microcephaly and birth defects. Ion channels, neurotransmitters and second messenger systems constitute molecular targets of AEDs. The same targets regulate brain processes essential both for propagation of seizures and for learning, memory and emotional behavior. Thus, AEDs can influence brain function and brain development in undesired ways. Here we review mechanisms of action of AEDs, examine clinical evidence for their adverse effects in the developing human brain, and present studies on cognitive and behavioral effects in animal models. Furthermore, we discuss mechanisms responsible for adverse effects of AEDs in the developing mammalian brain, including interference with cell proliferation and migration, axonal arborization, synaptogenesis, synaptic plasticity and physiological apoptotic cell death.

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Crossref · 10.1007/s00018-005-5348-0

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179 of 179 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Anti-epileptic drugs, given at young age or during pregnancy, can have major neurodevelopmental implications.

    “Important is also that the anti-epileptic drugs, given at young age or during pregnancy, can have major neurodevelopmental implications as well.”

    From Development of prefrontal cortex (2022) · cites this paper as [391]

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Authors
Kaindl, A. M., Asimiadou, S., Manthey, D., Hagen, M. V. D., Turski, L., & Ikonomidou, C.
Affiliations
  • Stiftung Charité (DE)
  • Technische Universität Dresden (DE)
  • Solvay (Netherlands) (NL)
Corresponding author
Ikonomidou, C.
Venue
Cellular and Molecular Life Sciences CMLS
Published
2006-01-02
Volume
63
Issue
4
Pages
399-413
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W1963567657
Cited by
121
References
179
Citations by year
2026: 4 · 2025: 6 · 2024: 5 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 12 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
8.68
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords
antiepileptic drugs, adverse drug reactions, developing brain, epilepsy, cognitive impairment, microcephaly, congenital malformations, ion channels, neurotransmitters, second messenger signaling, seizure propagation, learning and memory, behavioral effects, cell proliferation, neuronal migration, axonal arborization, synaptogenesis, synaptic plasticity, apoptosis, prenatal drug exposure
MeSH terms
Animals, Anticonvulsants, Brain, Epilepsy, Humans, Neurons, Apoptosis

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