The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A Trial of Artemether or Quinine in Children with Cerebral Malaria
Open accessAbstract
BACKGROUND: Cerebral malaria has a mortality rate of 10 to 30 percent despite treatment with parenteral quinine, a situation that may worsen with the spread of quinine resistance. Artemether is a new antimalarial agent that clears parasites from the circulation more rapidly than quinine, but its effect on mortality is unclear. METHODS: We conducted a randomized, unblinded comparison of intramuscular artemether and intramuscular quinine in 576 Gambian children with cerebral malaria. The primary end points of the study were mortality and residual neurologic sequelae. RESULTS: Fifty-nine of the 288 children treated with artemether died in the hospital (20.5 percent), as compared with 62 of the 288 treated with quinine (21.5 percent). Among the 418 children analyzed at approximately five months for neurologic disease, residual neurologic sequelae were detected in 7 of 209 survivors treated with artemether (3.3 percent) and 11 of 209 survivors treated with quinine (5.3 percent, P = 0.5). After adjustment for potential confounders, the odds ratio for death was 0.84 (95 percent confidence interval, 0.53 to 1.32) in the artemether group, and for residual neurologic sequelae, 0.51 (95 percent confidence interval, 0.17 to 1.47). There were fewer local reactions at the injection site with artemether than with quinine (0.7 percent vs. 5.9 percent, P = 0.001). CONCLUSIONS: Artemether is as effective as quinine in the treatment of cerebral malaria in children.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Indicators of Life-Threatening Malaria in African Children
Marsh, K., Forster, D., Waruiru, C., Mwangi, I., Winstanley, M., Marsh, V., Newton, C., Winstanley, P., Warn, P., Peshu, N., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322102 · Cited by 1,097
(1989) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068338 · Cited by 693
HIEN, D. (1993) · The Lancet · doi:10.1016/0140-6736(93)90362-k · Cited by 419
Severe Hypoglycemia and Hyperinsulinemia in Falciparum Malaria
White, N. J., Warrell, D. A., Chanthavanich, P., Looareesuwan, S., Warrell, M. J., Krishna, S., Williamson, D. H., & Turner, R. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307143090201 · Cited by 413
Neurotoxicity in animals due to arteether and artemether
Brewer, T. G., Peggins, J. O., Grate, S. J., Petras, J. M., Levine, B. S., Weina, P. J., Swearengen, J., Heiffer, M. H., & Schuster, B. G. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90469-3 · Cited by 254
Adult mortality in developing countries
Murray, C. J. L., & Feachem, R. G. A. (1990) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(90)90364-k · Cited by 226
HYPOGLYCAEMIA IN AFRICAN CHILDREN WITH SEVERE MALARIA
White, N. J., Marsh, K., Turner, R. C., Miller, K. D., Berry, C. D., Williamson, D. H., & Brown, J. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90354-0 · Cited by 221
Anti-TNF therapy inhibits fever in cerebral malaria
(1993) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068783 · Cited by 200
Taylor, T. E., Molyneux, M. E., Wirima, J. J., Fletcher, K. A., & Morris, K. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810203191602 · Cited by 198
Cited by
Contradicted and Initially Stronger Effects in Highly Cited Clinical Research
Ioannidis, J. P. A. (2005) · JAMA · doi:10.1001/jama.294.2.218 · Cited by 1,465
White, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
World Health Organization (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90300-6 · Cited by 1,085
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67176-0 · Cited by 1,050
Recent Natural Products Based Drug Development: A Pharmaceutical Industry Perspective
Shu, Y.-Z. (1998) · Journal of Natural Products · doi:10.1021/np9800102 · Cited by 517
Metadata
- Authors
- van Hensbroek, M. B., Onyiorah, E., Jaffar, S., Schneider, G., Palmer, A., Frenkel, J., Enwere, G., Forck, S., Nusmeijer, A., Bennett, S., Greenwood, B., & Kwiatkowski, D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-07-11
- Volume
- 335
- Issue
- 2
- Pages
- 69-75
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2313139941
- Cited by
- 257
- References
- 16
- FWCI
- 38.15
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Trial of Artemether or Quinine in Children with Cerebral Malaria. https://app.cochat.ai/papers/10.1056/nejm199607113350201
- The paper
- van Hensbroek, M. B., Onyiorah, E., Jaffar, S., Schneider, G., Palmer, A., Frenkel, J., Enwere, G., Forck, S., Nusmeijer, A., Bennett, S., Greenwood, B., & Kwiatkowski, D. (1996). A Trial of Artemether or Quinine in Children with Cerebral Malaria. New England Journal of Medicine. https://doi.org/10.1056/nejm199607113350201
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
