The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Ganciclovir
Abstract
Ganciclovir is a nucleoside analogue of guanosine, a homologue of acyclovir, and the first antiviral drug to be effective in the treatment of cytomegalovirus (CMV) disease in humans.14 It inhibits not only all the herpesviruses but also the transformation of normal cord-blood lymphocytes by Epstein–Barr virus.57 In this review, I outline ganciclovir's mechanisms of action and resistance and discuss the clinical effectiveness of intravenous and oral ganciclovir.Mechanism of ActionThe structures of ganciclovir and of its analogue acyclovir are shown in Figure 1. In vivo, ganciclovir is converted to ganciclovir triphosphate, which inhibits viral DNA polymerases, including those . . .
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Schmidt, G. M., Horak, D. A., Niland, J. C., Duncan, S. R., Forman, S. J., Zaia, J. A., & the City of Hope–Stanford–Syntex CMV Study Group* (1991) · New England Journal of Medicine · doi:10.1056/nejm199104113241501 · Cited by 616
Goodrich, J. M., Mori, M., Gleaves, C. A., Du Mond, C., Cays, M., Ebeling, D. F., Buhles, W. C., DeArmond, B., & Meyers, J. D. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252303 · Cited by 599
Reed, E. C., Bowden, R. A., Dandliker, P. S., Lilleby, K. E., & Meyers, J. D. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-10-783 · Cited by 548
Emanuel, D., Cunningham, I., Jules-Elysee, K., Brochstein, J. A., Kernan, N. A., Laver, J., Stover, D., White, D. A., Fels, A., Polsky, B., et al. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-10-777 · Cited by 490
(1992) · New England Journal of Medicine · doi:10.1056/nejm199201233260401 · Cited by 487
Sullivan, V., Talarico, C. L., Stanat, S. C., Davis, M., Coen, D. M., & Biron, K. K. (1992) · Nature · doi:10.1038/358162a0 · Cited by 471
Collaborative DHPG Treatment Study Group (1986) · New England Journal of Medicine · doi:10.1056/nejm198603273141301 · Cited by 427
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Cytomegalovirus Retinitis and Acquired Immunodeficiency Syndrome
Jabs, D. A. (1989) · Archives of Ophthalmology · doi:10.1001/archopht.1989.01070010077031 · Cited by 379
A Controlled Trial of Ganciclovir to Prevent Cytomegalovirus Disease after Heart Transplantation
Merigan, T. C., Renlund, D. G., Keay, S., Bristow, M. R., Starnes, V., O'Connell, J. B., Resta, S., Dunn, D., Gamberg, P., Ratkovec, R. M., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199204303261803 · Cited by 376
Cited by
Zhang, L., Inniss, M. C., Han, S., Moffat, M., Jones, H., Zhang, B., Cox, W. L., Rance, J. R., & Young, R. J. (2015) · Biotechnology Progress · doi:10.1002/btpr.2175 · Cited by 97
Studahl, M., Lindquist, L., Eriksson, B.-M., Günther, G., Bengner, M., Franzen-Röhl, E., Fohlman, J., Bergström, T., & Aurelius, E. (2013) · Drugs · doi:10.1007/s40265-013-0007-5 · Cited by 90
Metadata
- Authors
- Crumpacker, C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1996-09-05
- Volume
- 335
- Issue
- 10
- Pages
- 721-729
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4231692149
- Cited by
- 382
- References
- 33
- FWCI
- 22.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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