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The Esophagogastric Junction
Abstract
The lower esophageal sphincter regulates the flow of food between the esophagus and the stomach. It is now clear that both the intrinsic smooth muscle of the distal esophagus and the skeletal muscle of the crural diaphragm constitute the sphincter mechanism at the lower end of the esophagus.1 Furthermore, in normal subjects and patients with reflux esophagitis, transient relaxation of both sphincters rather than diminished lower esophageal sphincter pressure is the major mechanism of gastroesophageal reflux.2 In this article we review the current understanding of the physiology of the sphincter mechanism at the esophagogastric junction and its relation to esophageal . . .
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Citations
Cited by
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Pathophysiology of Gastroesophageal Reflux Disease
Tack, J., & Pandolfino, J. E. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.09.047 · Cited by 417
The 2018 ISDE achalasia guidelines
Zaninotto, G., Bennett, C., Boeckxstaens, G., Costantini, M., Ferguson, M. K., Pandolfino, J. E., Patti, M. G., Ribeiro, U., Richter, J., Swanstrom, L., et al. (2018) · Diseases of the Esophagus · doi:10.1093/dote/doy071 · Cited by 357
The role of the hiatus hernia in gastro‐oesophageal reflux disease
Gordon, C., Kang, J. Y., Neild, P. J., & Maxwell, J. D. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02149.x · Cited by 204
Fundamentals of Neurogastroenterology: Physiology/Motility – Sensation
Boeckxstaens, G., Camilleri, M., Sifrim, D., Houghton, L. A., Elsenbruch, S., Lindberg, G., Azpiroz, F., & Parkman, H. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.030 · Cited by 142
Metadata
- Authors
- Mittal, R. K., & Balaban, D. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-03-27
- Volume
- 336
- Issue
- 13
- Pages
- 924-932
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2316070389
- Cited by
- 644
- References
- 0
- FWCI
- 20.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Esophagogastric Junction. https://app.cochat.ai/papers/10.1056/nejm199703273361306
- The paper
- Mittal, R. K., & Balaban, D. H. (1997). The Esophagogastric Junction. New England Journal of Medicine. https://doi.org/10.1056/nejm199703273361306
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
