The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
The role of the hiatus hernia in gastro‐oesophageal reflux disease
Abstract
Summary: A sliding hiatus hernia disrupts both the anatomy and physiology of the normal antireflux mechanism. It reduces lower oesophageal sphincter length and pressure, and impairs the augmenting effects of the diaphragmatic crus. It is associated with decreased oesophageal peristalsis, increases the cross‐sectional area of the oesophago‐gastric junction, and acts as a reservoir allowing reflux from the hernia sac into the oesophagus during swallowing. The overall effect is that of increased oesophageal acid exposure. The presence of a hiatus hernia is associated with symptoms of gastro‐oesophageal reflux, increased prevalence and severity of reflux oesophagitis, as well as Barrett's oesophagus and oesophageal adenocarcinoma. The efficacy of treatment with proton pump inhibitors is reduced. Our view on the significance of the sliding hiatus hernia in gastro‐oesophageal reflux disease has changed enormously in recent decades. It was initially thought that a hiatus hernia had to be present for reflux oesophagitis to occur. Subsequently, the hiatus hernia was considered an incidental finding of little consequence. We now appreciate that the hiatus hernia has major patho‐physiological effects favouring gastro‐oesophageal reflux and hence contributing to oesophageal mucosal injury, particularly in patients with severe gastro‐oesophageal reflux disease.
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“Other studies, however, have shown it to be similar to the background population (8–26% in HSD/hEDS vs 2–22% general population) suggesting hiatus hernia may not be the main mechanism responsible for the commonly reported symptom of reflux. 14 , 28 , 42 , 43 , 44”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [42]
Citations
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Cited by
Rosen, R., Vandenplas, Y., Singendonk, M. M. J., Cabana, M. D., DiLorenzo, C., Gottrand, F., Gupta, S. K., Langendam, M. W., Staiano, A., Thapar, N., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001889 · Cited by 1,611
Vandenplas, Y., Rudolph, C. D., Committee Members:, Di Lorenzo, C., Hassall, E., Liptak, G., Mazur, L., Sondheimer, J., Staiano, A., Thomson, M., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181b7f563 · Cited by 742
Guidelines for the management of hiatal hernia
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Prevalence of hiatal hernia in the morbidly obese
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Veugelers, P. J., Porter, G. A., Guernsey, D. L., & Casson, A. G. (2006) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2006.00602.x · Cited by 181
Metadata
- Authors
- Gordon, C., Kang, J. Y., Neild, P. J., & Maxwell, J. D.
- Affiliations
- St George's Hospital (GB)
- Corresponding author
- Kang, J. Y.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2004-09-16
- Volume
- 20
- Issue
- 7
- Pages
- 719-732
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2004830815
- Cited by
- 204
- References
- 119
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 14 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 16
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- gastroesophageal reflux disease, antireflux mechanism, lower esophageal sphincter, esophageal peristalsis, esophageal acid exposure, reflux esophagitis, Barrett's esophagus, esophageal adenocarcinoma, proton pump inhibitors
- MeSH terms
- Esophagogastric Junction, Gastric Acid, Gastroesophageal Reflux, Hernia, Hiatal, Humans, Manometry, Obesity, Peristalsis, Incidence, Prevalence, Endoscopy, Gastrointestinal
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- Gordon, C., Kang, J. Y., Neild, P. J., & Maxwell, J. D. (2004). The role of the hiatus hernia in gastro‐oesophageal reflux disease. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/j.1365-2036.2004.02149.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
