The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Paternity by Intrauterine Insemination with Sperm from a Man with 5α-Reductase-2 Deficiency
Open accessAbstract
Male pseudohermaphroditism results from the abnormal differentiation of male external genitalia in a genotypic male. One cause of male pseudohermaphroditism is a deficiency of 5α-reductase-2, the enzyme that converts testosterone to 5α-dihydrotestosterone in specific androgen-dependent target tissues.1–3 Males who are homozygous for the disorder usually present with pseudovaginal perineoscrotal hypospadias at birth. Most have distinct urethral and vaginal openings within a urogenital sinus and a clitoris-like phallus. Virilization occurs at puberty with phallic growth, rugation and pigmentation of the scrotum, and testicular descent.1–3 At this time, the voice deepens and muscle mass increases, with the development of a . . .
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“T and DHT also likely have differential roles and expression in various tissues, including in the prostate, skin, penis, and testicles, among others.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [29]
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Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
Imperato-McGinley, J., Guerrero, L., Gautier, T., & Peterson, R. E. (1974) · Science · doi:10.1126/science.186.4170.1213 · Cited by 1,258
Self-citationFamilial Incomplete Male Pseudohermaphroditism, Type 2
Walsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., MacDonald, P. C., & Wilson, J. D. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410312911806 · Cited by 621
Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo
Siiteri, P. K., & Wilson, J. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-1-113 · Cited by 591
Imperato‐McGinley, J., Peterson, R. E., Gautier, T., & Sturla, E. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905313002201 · Cited by 444
Self-citationMale pseudohermaphroditism due to steroid 5α-reductase deficiency
Peterson, R. E., Imperato‐McGinley, J., Gautier, T., & Sturla, E. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90313-8 · Cited by 392
Self-citationNew method of evaluating sperm morphology with predictive value for human in vitro fertilization
Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., Veeck, L. L., Morshedi, M., & Brugo, S. (1987) · Urology · doi:10.1016/0090-4295(87)90246-9 · Cited by 260
Imperato‐McGinley, J., Sanchez, R. S., Spencer, J. R., Yee, B., & Vaughan, E. D. (1992) · Endocrinology · doi:10.1210/endo.131.3.1324152 · Cited by 246
Self-citationMale pseudohermaphroditism: The complexities of male phenotypic development
Imperato‐McGinley, J., & Peterson, R. E. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90175-3 · Cited by 156
Self-citationProstate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency
Imperato‐McGinley, J., Gautier, T., Zirinsky, K., Hom, T., Palomo, O., Stein, E. A., Vaughan, E. D., Markísz, J. A., de Arellano, E. R., & Kazam, E. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400866 · Cited by 153
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Research works printed but not linked: 6
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Metadata
- Authors
- Katz, M. D., Kligman, I., Cai, L.-Q., Zhu, Y.-S., Fratianni, C. M., Zervoudakis, I., Rosenwaks, Z., & Imperato-McGinley, J.
- Affiliations
- Cornell University (US)
- ORCID
- Zhu, Yuan-Shan
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-04-03
- Volume
- 336
- Issue
- 14
- Pages
- 994-998
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2333993541
- Cited by
- 131
- References
- 26
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 16 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 1 · 2016: 10 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32hl009421-02)
- National Heart, Lung, and Blood Institute (HL-09421-15)
- National Center for Research Resources (M01RR 00047, M01RR000047)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- intrauterine insemination, 46,XY disorders of sex development, dihydrotestosterone, androgen insensitivity syndrome, hypospadias, paternity, male infertility, congenital adrenal hyperplasia
- MeSH terms
- Adult, Female, Humans, Infertility, Male, Insemination, Artificial, Homologous, Isoenzymes, Male, Mutation, Pregnancy, Disorders of Sex Development, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Uterus
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