Cited by 634Pregnancy and preeclampsia studiesNeurological Complications and SyndromesBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.

Trial of Calcium to Prevent Preeclampsia

Open access

Levine, Richard J., Hauth, John C., Curet, Luis B., Sibai, Baha M., Catalano, Patrick M., Morris, Cynthia D., DerSimonian, Rebecca, Esterlitz, Joy R., Raymond, Elizabeth G., Bild, Diane E., Clemens, John D., Cutler, Jeffrey A., Ewell, Marian G., Friedman, Steven A., Goldenberg, Robert L., Jacobson, Sig-Linda, Joffe, Gary M., Klebanoff, Mark A., Petrulis, Alice S.·1997·New England Journal of Medicine

DOI 10.1056/nejm199707103370201

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Previous trials have suggested that calcium supplementation during pregnancy may reduce the risk of preeclampsia. However, differences in study design and a low dietary calcium intake in the populations studied limit acceptance of the data. METHODS: We randomly assigned 4589 healthy nulliparous women who were 13 to 21 weeks pregnant to receive daily treatment with either 2 g of elemental calcium or placebo for the remainder of their pregnancies. Surveillance for preeclampsia was conducted by personnel unaware of treatment-group assignments, using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits, protocols for monitoring these measurements during the hospitalization for delivery, and reviews of medical records of unscheduled outpatient visits and all hospitalizations. RESULTS: Calcium supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. Preeclampsia occurred in 158 of the 2295 women in the calcium group (6.9 percent) and 168 of the 2294 women in the placebo group (7.3 percent) (relative risk, 0.94; 95 percent confidence interval, 0.76 to 1.16). There were no significant differences between the two groups in the prevalence of pregnancy-associated hypertension without preeclampsia (15.3 percent vs. 17.3 percent) or of all hypertensive disorders (22.2 percent vs. 24.6 percent). The mean systolic and diastolic blood pressures during pregnancy were similar in both groups. Calcium did not reduce the numbers of preterm deliveries, small-for-gestational-age births, or fetal and neonatal deaths; nor did it increase urolithiasis during pregnancy. CONCLUSIONS: Calcium supplementation during pregnancy did not prevent preeclampsia, pregnancy-associated hypertension, or adverse perinatal outcomes in healthy nulliparous women.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejm199707103370201

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Analysis of Longitudinal Data
Everitt, B. S. (2001) · Psychology Press eBooks · doi:10.4324/9781410605542-11 · Cited by 6,877
Epidemiologic Research: Principles and Quantitative Methods.
Mayer, L. S., Kleinbaum, D. G., Kupper, L. L., & Morgenstern, H. (1984) · Journal of the American Statistical Association · doi:10.2307/2288427 · Cited by 2,905
A standard of fetal growth for the united states of America
Brenner, W. E., Edelman, D. A., & Hendricks, C. H. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90748-1 · Cited by 847
Hypertensive disorders in pregnancy
Chesley, L. C. (1985) · Journal of Nurse-Midwifery · doi:10.1016/0091-2182(85)90116-8 · Cited by 632
Calcium Metabolism in Normal Human Pregnancy
Heaney, R. P., & Skillman, T. G. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-4-661 · Cited by 363
Determination of Calcium in Urine and Serum by Atomic Absorption Spectrophotometry (AAS)
Trudeau, D. L., & Freier, E. F. (1967) · Clinical Chemistry · doi:10.1093/clinchem/13.2.101 · Cited by 304
Calcium Supplementation to Prevent Hypertensive Disorders of Pregnancy
Belizán, J. M., Villar, J., González, L. M., Campodonico, L., & Bergel, E. F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111143252002 · Cited by 273
META-ANALYSIS IN THE DESIGN AND MONITORING OF CLINICAL TRIALS
DerSimonian, R. (1996) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19960630)15:12 · Cited by 257
Self-citation
Effect of Calcium Supplementation on Pregnancy-Induced Hypertension and Preeclampsia
Bucher, H. C. (1996) · JAMA · doi:10.1001/jama.1996.03530380055031 · Cited by 243

Flagged first, then by citations

Show all 33 references

2 of the 33 references couldn’t be matched to a known paper.

Research works printed but not linked: 9

1942, Lancet, 2, 10
Chaudhuri SK, 1969, J Obstet Gynaecol India, 19, 313
Montanaro D, 1986, Miner Metab Res Italy, 7, 121
Sanchez-Ramos L, 1994, Obstet Gynecol, 84, 349
Cong K, 1993, Chung Hua Fu Chan Ko Tsa Chih, 28, 657
Levine RJ, 1992, Clin Appl Nutr, 2, 30
Hoffman RJ, 1988, Clin Chem, 34, 1313
Calcium and hypocalcemia. In: Klaus MH, Fanaroff AA, eds. Care of the high-risk neonate. 3rd ed. Philadelphia: W.B. Saunders, 1986:227-31.
Villar J, 1987, Obstet Gynecol, 70, 317

Sorted by citations

Items 301–400 of 633

Hypertension and Kidney Disease in Pregnancy
Maynard, S. E., Karumanchi, S. A., & Thadhani, R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6193-9.10048-x · Cited by 22
Hypertensive Disorders
Polley, L. S. (2009) · Elsevier eBooks · doi:10.1016/b978-0-323-05541-3.00045-4 · Cited by 22
Importance of Calcium
Tandoğan, B., & Ulusu, N. N. (2005) · DergiPark (Istanbul University) · Cited by 22
Late-Preterm Birth by Delivery Circumstance and Its Association With Parent-Reported Attention Problems in Childhood
Talge, N. M., Holzman, C., Egeren, L. A. V., Symonds, L. L., Scheid, J. M., Senagore, P. K., & Sikorskii, A. E. (2012) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3182564704 · Cited by 21
Goals and Strategies for Prevention of Preterm Birth: An Obstetric Perspective
Lang, C., & Iams, J. D. (2009) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2009.03.006 · Cited by 21
Reported Calcium Intake is Reduced in Women with Preeclampsia
Ramos, J. G. L., Brietzke, E. M., Costa, S. H. D. A. M., Vettorazzi, J., Barros, E., & Carvalho, C. G. (2006) · Hypertension in Pregnancy · doi:10.1080/10641950600913008 · Cited by 21
Prevention of preeclampsia
Mattar, F., & Sibai, B. M. (1999) · Seminars in Perinatology · doi:10.1016/s0146-0005(99)80060-3 · Cited by 21
Self-citation
First Trimester Placental Retinol-Binding Protein 4 (RBP4) and Pregnancy-Associated Placental Protein A (PAPP-A) in the Prediction of Early-Onset Severe Pre-Eclampsia
Yliniemi, A., Nurkkala, M.-M., Kopman, S., Korpimäki, T., Kouru, H., Ryynänen, M., & Marttala, J. (2014) · Metabolism · doi:10.1016/j.metabol.2014.12.008 · Cited by 20
Pre-treatment with calcium prevents endothelial cell activation induced by multiple activators, necrotic trophoblastic debris or IL-6 or preeclamptic sera: Possible relevance to the pathogenesis of preeclampsia
Chen, Q., Zhang, Y., Tong, M., Wu, M., Snowise, S., STONE, P. R., & Chamley, L. (2013) · Placenta · doi:10.1016/j.placenta.2013.09.014 · Cited by 20
Preterm Labor and Birth
Simhan, H. N., Iams, J. D., & Romero, R. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-32108-2.00029-9 · Cited by 21
Hypertensive Disorders of Pregnancy
Lyell, D. J. (2004) · NeoReviews · doi:10.1542/neo.5-6-e240 · Cited by 20
Retinol-Binding Protein 4 and Lipids Prospectively Measured During Early to Mid-Pregnancy in Relation to Preeclampsia and Preterm Birth Risk
Mendola, P., Ghassabian, A., Mills, J. L., Zhang, C., Tsai, M. Y., Liu, A., & Yeung, E. H. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx020 · Cited by 19
Maternal serum markers of lipid metabolism in relation to neonatal anthropometry
Boghossian, N. S., Mendola, P., Liu, A., Robledo, C. A., & Yeung, E. H. (2017) · Journal of Perinatology · doi:10.1038/jp.2017.22 · Cited by 19
Longitudinal measures of maternal vitamin D and neonatal body composition
Boghossian, N. S., Koo, W., Liu, A., Mumford, S. L., Tsai, M. Y., & Yeung, E. H. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0212-0 · Cited by 19
An innovative implementation strategy to improve the use of Dutch guidelines on hypertensive disorders in pregnancy: A randomized controlled trial
Luitjes, S., Hermens, R., de Wit, L., Heymans, M. W., van Tulder, M. W., & Wouters, M. G. A. J. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.08.451 · Cited by 19
Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery
Mijal, R. S., Holzman, C., Rana, S., Karumanchi, S. A., Wang, J., & Sikorskii, A. E. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.625458 · Cited by 19
Up-regulation of LncRNA NEAT1 induces apoptosis of human placental trophoblasts
Fan, X., Xiujuan, Z., Jianyi, L., Liyan, Y., Ting, Y., & Hu, M. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1826468 · Cited by 18
Renal Physiology and Disease in Pregnancy
Lindheimer, M. D., Conrad, K. P., & Karumanchi, S. A. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50086-3 · Cited by 18
A Suggested Approach for Implementing CONSORT Guidelines Specific to Obstetric Research
Chauhan, S. P., Blackwell, S. C., & Saade, G. R. (2013) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182a9c9af · Cited by 18
Nutrition in Multiple Gestations
Luke, B. (2005) · Clinics in Perinatology · doi:10.1016/j.clp.2005.02.005 · Cited by 18
CURRENT CONCEPTS ON THE PATHOGENESIS AND MARKERS OF PRETERM BIRTHS
Lu, G., & Goldenberg, R. L. (2000) · Clinics in Perinatology · doi:10.1016/s0095-5108(05)70021-x · Cited by 19
Self-citation
Epidemiological Trends of Maternal Hypertensive Disorders of Pregnancy at the Global, Regional, and National Levels: A Population-Based StudyPreprint
Wang, W., Xie, X., Ting, Y., Wang, Y., Zhao, F., Zhou, Z., & Zhang, H. (2021) · Research Square · doi:10.21203/rs.3.rs-146936/v1 · Cited by 18
Preeclampsia prevention: a case-control study nested in a cohort.
Alzate, A., Herrera, R., & Pineda, L. M. (2015) · PubMed Central · Cited by 14
Calcium supplementation reducing the risk of hypertensive disorders of pregnancy and related problems: A meta‐analysis of multicentre randomized controlled trials
An, L., Li, W., Xie, T., Peng, X., Li, B., Xie, S., Xu, J., Zhou, X., & Guo, S. (2015) · International Journal of Nursing Practice · doi:10.1111/ijn.12171 · Cited by 16
Ambulatory Management of Chronic Hypertension in Pregnancy
Ames, M. B., RUEDA, J., & Caughey, A. B. (2012) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e31825c8bcd · Cited by 16
Medications for preventing hypertensive disorders in high-risk pregnant women: a systematic review and network meta-analysis
Liabsuetrakul, T., Yamamoto, Y., Kongkamol, C., Ota, E., Mori, R., & Noma, H. (2022) · Systematic Reviews · doi:10.1186/s13643-022-01978-5 · Cited by 17
Calcium Supplementation for the Prevention of Pre-eclampsia
Kumar, A., Devi, S. G., Batra, S., Singh, C., & Shukla, D. K. (2009) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000362087.80461.4f · Cited by 16
Management of pre-eclampsia and haemolysis, elevated liver enzymes, and low platelets syndrome
Anumba, D. O. C., & Robson, S. C. (1999) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199904000-00007 · Cited by 16
Maternal Nutrition and Adverse Pregnancy Outcomes: Lessons from Epidemiology
Kramer, M. S. (2004) · KARGER eBooks · doi:10.1159/000082589 · Cited by 16
Prevention or Early Treatment of Preeclampsia
Roberts, J. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370209 · Cited by 16
Kidney health outcomes of hypertensive disorders of pregnancy
Piccoli, G. B., Torreggiani, M., Schwotzer, N., Cabiddu, G., Attini, R., Orozco-Guillén, A., Shemies, R. S., Jesudason, S., Fakhouri, F., & Garovic, V. D. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00977-8 · Cited by 16
Pathophysiology and medical management of systemic hypertension in preeclampsia
Frishman, W. H., Veresh, M., Schlocker, S. J., & Tejani, N. A. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0030-y · Cited by 15
Medidas preventivas das síndromes hipertensivas da gravidez na atenção primária
Chaves, A. C. D. M., Wall, M. L., Benedet, D. C. F., Souza, S. R. R. K., & de Souza, M. A. R. (2018) · Revista de Enfermagem UFPE on line · doi:10.5205/1981-8963-v12i4a234605p1060-1071-2018 · Cited by 15
Increased risk of preeclampsia among nulliparous pregnant women with idiopathic hematuria
Stehman‐Breen, C. O., Levine, R. J., Qian, C., Morris, C. D., Catalano, P. M., Curet, L. B., & Sibai, B. M. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.125768 · Cited by 15
Self-citation
Nutrition and Maternal Survival in Developing Countries
Christian, P. S. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-112-3_21 · Cited by 15
The Management of Thrombophilia During Pregnancy: A Canadian Survey
Rodger, M. A., Carrier, M., Keely, E., Karovitch, A. J., Nimrod, C. A., WALKER, M. C., & Wells, P. S. (2002) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)30593-x · Cited by 15
La pré-éclampsie : recommandations pour la pratique clinique du Collège national des gynécologues obstétriciens français
Sentilhes, L., Schmitz, T., Arthuis, C., Barjat, T. R., Berveiller, P., Camilleri, C., Froeliger, A., Garabédian, C., Guerby, P., Korb, D., et al. (2023) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2023.10.002 · Cited by 17
Calcium level during the first trimester of pregnancy as a predictor of preeclampsia
Gabbay, A., Tzur, T., Weintraub, A. Y., Shoham‐Vardi, I., Sergienko, R., & Sheiner, E. (2014) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.877925 · Cited by 14
Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis
Korhonen, P. H., Tihtonen, K. M. H., Isojärvi, J., Ojala, R., Ashorn, U., Ashorn, P., & Tammela, O. K. T. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14729 · Cited by 14
Different Doses of Calcium Supplementation to Prevent Gestational Hypertension and Pre-Eclampsia: A Systematic Review and Network Meta-Analysis
Chen, D., Hong, W., Xing, X., Zhang, L., Yu, A., Li, S., & He, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.795667 · Cited by 16
Serum 25-hydroxyvitamin D, calcium, and calcium-regulating hormones in preeclamptics and controls during first day postpartum
Dalmar, A., Raff, H., Chauhan, S. P., Singh, M., & Siddiqui, D. S. (2014) · Endocrine · doi:10.1007/s12020-014-0296-9 · Cited by 14
Early onset preeclampsia and second trimester serum markers
Lambert-Messerlian, G. M., Palomaki, G. E., Neveux, L. M., Chien, E. K., Friedman, A., Rosene‐Montella, K., Hayes, M. K., & Canick, J. A. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2387 · Cited by 14
Pre-eclampsia: is it all in the placenta?
Singh, H. J. (2009) · Europe PMC (PubMed Central) · Cited by 14
Pregnancy outcomes in smokers who develop pre‐eclampsia
Beste, L. A., England, L. J., Schisterman, E. F., Qian, C., Yu, K. F., & Levine, R. J. (2005) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2004.00617.x · Cited by 14
Self-citation
Prediction and Prevention
Briceño-Pérez, C., Briceño‐Sanabria, L., & Gracia, P. V. (2009) · Cited by 14
Association between calcium supplementation and gestational hypertension, and preeclampsia: A Meta-analysis of 26 randomized controlled trials
Jaiswal, V., Joshi, A., Jha, M., Hanif, M., Arora, A., Gupta, S., Shah, M., Deb, N., Ang, S. P., Aujla, S., et al. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102217 · Cited by 13
Pre‐eclampsia and cardiovascular disease: more questions than answers?
Ananth, C., & Cleary, K. L. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12215 · Cited by 13
Impact of Physical Activity During Pregnancy on Gestational Hypertension
Gao, Y., Ren, S., Zhou, H., & Xuan, R. (2020) · Physical Activity and Health · doi:10.5334/paah.49 · Cited by 13
Neonatal outcomes of extremely preterm infants exposed to maternal hypertension and cigarette smoking
on behalf of the Canadian Neonatal Network Investigators, Yusuf, K., Alshaikh, B. N., da Silva, O., Lodha, A. K., Wilson, R. D., Alvaro, R. E., Lee, S. K., & Shah, P. S. (2018) · Journal of Perinatology · doi:10.1038/s41372-018-0111-1 · Cited by 13
Intermediate outcomes in randomized clinical trials: an introduction
Seuc, A. H., Peregoudov, A., Betrán, A. P., & Gülmezoglu, A. M. (2013) · Trials · doi:10.1186/1745-6215-14-78 · Cited by 13
Study protocol: Cost effectiveness of two strategies to implement the NVOG guidelines on hypertension in pregnancy: An innovative strategy including a computerised decision support system compared to a common strategy of professional audit and feedback, a randomized controlled trial
Luitjes, S., Wouters, M. G. A. J., Franx, A., Scheepers, H. C. J., Coupé, V. M. H., Wollersheim, H., Steegers, E. A. P., Heringa, M. P., Hermens, R., & van Tulder, M. W. (2010) · Implementation Science · doi:10.1186/1748-5908-5-68 · Cited by 13
Nutrition for Multiples
Luke, B. (2015) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000117 · Cited by 13
Prevention of Preeclampsia and Eclampsia
Staff, A. C., Sibai, B. M., & Cunningham, F. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407866-6.00012-2 · Cited by 13
Self-citation
La prevención de la preeclampsia: un estudio de casos y controles anidado en una cohorte
Alzate, A., Herrera, R., & Pineda, L. M. (2015) · Colombia medica · doi:10.25100/cm.v46i4.1887 · Cited by 12
Preterm Birth 2: Primary, Secondary, and Tertiary Interventions to Reduce the Morbidity and Mortality of Preterm Birth
Iams, J. D., Romero, R. J., Culhane, J. F., & Goldenberg, R. L. (2009) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000344667.20582.bf · Cited by 12
Self-citation
Seasonal variation of the onset of preeclampsia and eclampsia
Soroori, Z. Z., Sharami, S. H., & Faraji, R. (2007) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 13
Maternal Healthcare in Bangladesh and Gender Equity: A Review Article
Walton, L. M., & Schbley, B. (2013) · Journal of Health Ethics · doi:10.18785/ojhe.0901.08 · Cited by 12
Variation in outcome reporting in randomized controlled trials of interventions for prevention and treatment of fetal growth restriction
Townsend, R., Sileo, F. G., Stocker, L. J., Kumbay, H., Healy, P., Gordijn, S. J., Ganzevoort, W., Beune, I. M., Baschat, A., Kenny, L. C., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20189 · Cited by 12
Nutrition During Pregnancy
West, E. H., Hark, L. A., & Catalano, P. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-32108-2.00007-x · Cited by 12
Self-citation
Maternal Mortality in Developing Countries
Ronsmans, C., Collin, S. M., & Filippi, V. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-464-3_2 · Cited by 12
Preeclampsia – abnormal uterine artery Doppler is related to recurrence of symptoms during the next pregnancy
Gudnasson, H. M., Dubiel, M., & Gudmundsson, S. (2004) · Journal of Perinatal Medicine · doi:10.1515/jpm.2004.135 · Cited by 12
Hypertensive disorders of pregnancy: preventative-, immediate- and long-term management
Nelson, S. M., & Greer, I. A. (2006) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.6.5.541 · Cited by 12
Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women
Aghamohammadi, A., & Zafari, M. (2015) · ScienceAsia · doi:10.2306/scienceasia1513-1874.2015.41.259 · Cited by 12
Maternal Calcium Intake and Metabolism During Pregnancy and Lactation
Heringhausen, J. E., & Montgomery, K. S. (2005) · The Journal of Perinatal Education · doi:10.1624/105812405x23621 · Cited by 12
Properties of A Nonparametric Test for Early Comparison of Treatments in Clinical Trials in the Presence of Surrogate Endpoints
Venkatraman, E. S., & Begg, C. B. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.01171.x · Cited by 12
Socioeconomic status and intake of energy and sodium are associated with calcium intake among pregnant women in Rafsanjan city, Iran
Ebrahimi, F., Shariff, Z. M., Rezaeian, M., Tabatabaei, S. Z., Mun, C. Y., & Tajik, E. (2012) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2012.01948.x · Cited by 11
Pregnancy-Related Complications
Mills, A. M., & Datner, E. M. (2008) · Pediatric Emergency Medicine · doi:10.1016/b978-141600087-7.50094-5 · Cited by 11
Biological indicators of thein-uteroenvironment and their association with birth weight for gestational age
Talge, N. M., Holzman, C., Senagore, P. K., Klebanoff, M. A., & Fisher, R. A. (2011) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174411000298 · Cited by 11
Self-citation
Serum Electrolyte Levels In Preeclamptic Women: A Comparative Study
Manjareeka, M. (2012) · International Journal of Pharma and Bio Sciences · Cited by 11
Maternal Nutrition and Preterm Delivery
Scholl, T. O. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-542-2_26 · Cited by 10
Counseling for women with preeclampsia or eclampsia
Witlin, A. G. (1999) · Seminars in Perinatology · doi:10.1016/s0146-0005(99)80063-9 · Cited by 11
Diagnosis of hypertensive disorders in pregnancy
Horgan, R., Diab, Y. H., Costantine, M. M., Saade, G. R., & Sibai, B. (2025) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2025.101693 · Cited by 13
Self-citation
Frequency of consumption of specific food items and symptoms of preeclampsia and eclampsia in Indian women
Agrawal, S. (2014) · International Journal of Medicine and Public Health · doi:10.4103/2230-8598.144062 · Cited by 11
EBN (Evidence-Based Nutrition) Ver. 2.0
Heaney, R. P., Weaver, C. M., & Blumberg, J. B. (2011) · Nutrition Today · doi:10.1097/nt.0b013e3182076fdf · Cited by 10
No effect of calcium and vitamin D intake on maternal blood pressure in a healthy pregnant population
Forde, H. E., Crowley, R. K., McKenna, M. J., Kilbane, M. T., Conway, M. C., McDonnell, C. M., Twomey, P. J., & McAuliffe, F. M. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2021.07.005 · Cited by 10
État des connaissances : prise en charge thérapeutique de la prééclampsie
Winer, N., & Tsasaris, V. (2008) · Sages-Femmes · doi:10.1016/j.sagf.2008.03.008 · Cited by 10
Pre-Eclampsia, Soluble Fms-Like Tyrosine Kinase 1, and the Risk of Reduced Thyroid Function: Nested Case-Control and Population Based Study
Levine, R. J., VATTEN, L. J., Horowitz, G. L., Qian, C., Romundstad, P., Yu, K., Hollenberg, A. N., Hellevik, A. I., Åsvold, B. O., & Karumanchi, S. A. (2010) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000371706.24726.a4 · Cited by 10
Self-citation
Hypertension in special populations
Flack, J. M. (2003) · Current Problems in Cardiology · doi:10.1016/s0146-2806(03)00018-5 · Cited by 10
Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures
Maioli, E., Fortino, V., & Pacini, A. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.030932 · Cited by 10
Randomised trials in maternal and perinatal medicine: global partnerships are the way forward
Gülmezoglu, M., Villar, J., Hofmeyr, G. J., Duley, L., & Belizán, J. M. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10001.x · Cited by 10
Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia
Chen, M., Jin, Y., & Cao, X. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf071 · Cited by 11
Dietary supplements and vascular function in hypertensive disorders of pregnancy
Man, A. W. C., Zhou, Y., Xia, N., & Li, H. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02810-2 · Cited by 15
Predictive biomarkers of pre-eclampsia and effectiveness of preventative interventions for the disease
Inversetti, A., Smid, M., Candiani, M., Ferrari, M., & Galbiati, S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.912271 · Cited by 9
Vitamins and Minerals
LeMone, P. (1999) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.1999.tb02026.x · Cited by 9
First Trimester Screening for Pre-eclampsia and Fetal Growth Restriction
Selvaraj, L. R., Rose, N., & Ramachandran, M. (2016) · Journal of Fetal Medicine · doi:10.1007/s40556-016-0088-9 · Cited by 9
Role of High Dose Calcium in the Prevention of Preeclampsia
Khan, A., Mandal, S. K., & Pal, A. (2016) · Bangladesh Journal of Obstetrics & Gynaecology · doi:10.3329/bjog.v28i2.30092 · Cited by 9
Update on Pre-eclampsia
Haddad, T. (2002) · International Anesthesiology Clinics · doi:10.1097/00004311-200210000-00010 · Cited by 9
Effectiveness of calcium supplementation in the prevention of gestational hypertension: A systematic review and meta-analysis of randomised controlled trials
Zhu, Q., Qin, Y., Liu, M., & Wei, Y. (2024) · Pregnancy Hypertension · doi:10.1016/j.preghy.2024.101174 · Cited by 10
Preeclampsia
Townsend, N. S., & Drummond, S. B. (2011) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/jpn.0b013e318223ad14 · Cited by 8
Dietary determinants of pregnancy induced hypertension in Isfahan
Paknahad, Z., Talebi, N., & Azadbakht, L. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 8
Etiología y fisiopatología de la hipertensión arterial esencial
Bellido, C. M., Fernández, E., López, J. A., Simón, P. H., & Padial, L. R. (2003) · Cited by 7
Prévention de la prééclampsie
Deruelle, P., Girard, J. M., Coutty, N., & Subtil, D. (2010) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2010.02.014 · Cited by 8
TEMPORARY REMOVAL: The hypertensive disorders of pregnancy: ISSHP classification, diagnosis and management recommendations for international practice 2018.
Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C., Adoyi, G., & Ishaku, S. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.01.005 · Cited by 10
Retracted
Medical Issues from Preconception Through Delivery: A Roadmap for the Internist
Carson, M., & Ehrenthal, D. B. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.04.010 · Cited by 8
PREECLAMPSIA
Mattar, F., & Sibai, B. M. (1999) · Clinics in Liver Disease · doi:10.1016/s1089-3261(05)70051-9 · Cited by 8
Self-citation
Family Medicine Obstetrics: Pregnancy and Nutrition
Harnisch, J. M., Harnisch, P. H., & Harnisch, D. R. (2012) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2011.11.003 · Cited by 8
Calcium supplementation during pregnancy reduces risk of high blood pressure, pre-eclampsia and premature birth compared with placebo?
Sibai, B. M. (2010) · BMJ Evidence-Based Medicine · doi:10.1136/ebm1145 · Cited by 8
Self-citation
Platelet Activation, Sympathetic Tone, and Plasma Volume in Nulligravid Women of Reproductive Age
Damron, D. P., Bouchard, B. A., Shapiro, R. E., Schonberg, A. L., & Bernstein, I. M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000124805.04957.05 · Cited by 8
Hypertension in Pregnancy
Heazell, A. E. P., Norwitz, E. R., Kenny, L. C., & Baker, P. N. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511902529 · Cited by 8
Hypertensive Diseases in Pregnancy
Eruo, F. U., & Sibai, B. M. (2007) · doi:10.1002/9780470753293.ch38 · Cited by 8
Self-citation

Authors: Levine, R. J., Hauth, J. C., Curet, L. B., Sibai, B. M., Catalano, P. M., Morris, C. D., DerSimonian, R., Esterlitz, J. R., Raymond, E. G., Bild, D. E., Clemens, J. D., Cutler, J. A., Ewell, M. G., Friedman, S. A., Goldenberg, R. L., Jacobson, S.-L., Joffe, G. M., Klebanoff, M. A., & Petrulis, A. S.
Affiliations: National Institutes of Health (US)
University of Alabama at Birmingham (US)
University of New Mexico (US)
University of Tennessee Health Science Center (US)
MetroHealth Medical Center (US)
Oregon Health & Science University (US)
National Heart, Lung, and Blood Institute (US)
ORCID: Catalano, Patrick M.
Morris, Cynthia D.
Clemens, John D.
Goldenberg, Robert L.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1997-07-10
Volume: 337
Issue: 2
Pages: 69-77
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199707103370201
OpenAlex: W2084688828
Cited by: 634
References: 33
Citations by year: 2026: 6 · 2025: 6 · 2024: 11 · 2023: 11 · 2022: 14 · 2021: 17 · 2020: 13 · 2019: 11 · 2018: 19 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 26 · 2013: 22 · 2012: 34
FWCI: 45.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (N01-HD-5-3122, N01-HD-5-3121, N01-HD-5-3123)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: calcium supplementation, preeclampsia prevention, pregnancy, nulliparous women, gestational hypertension, hypertensive disorders of pregnancy, blood pressure in pregnancy, urinary protein excretion, urolithiasis, perinatal outcomes, preterm birth, small for gestational age
MeSH terms: Adult, Calcium, Female, Humans, Hypertension, Parity, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Proteinuria, United States, Urinary Calculi, Incidence, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Trial of Calcium to Prevent Preeclampsia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks