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Cited by 217Psychopathy, Forensic Psychiatry, Sexual OffendingSexuality, Behavior, and TechnologyHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 29 of the 34 references it cites were found in a registry or an index, and 5 are not checked yet.

Treatment of Men with Paraphilia with a Long-Acting Analogue of Gonadotropin-Releasing Hormone

Rösler, Ariel, Witztum, Eliezer·1998·New England Journal of Medicine
DOI 10.1056/nejm199802123380702
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Abstract

Background Men with deviant sexual behavior, or paraphilia, are usually treated with psychotherapy, antidepressant drugs, progestins, and antiandrogens, but these treatments are often ineffective. Selective inhibition of pituitary-gonadal function with a long-acting agonist analogue of gonadotropin-releasing hormone may abolish the deviant sexual behavior by reducing testosterone secretion. Methods In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months. The efficacy of therapy was evaluated monthly by the Intensity of Sexual Desire and Symptoms Scale and yearly by the Three Main Complaints questionnaire. Results All the men had a decrease in the number of deviant sexual fantasies and desires, from a mean (+/-SD) of 48+/-10 per week before therapy to zero during therapy (P Conclusions Continuous administration of triptorelin, a long-acting agonist analogue of gonadotropin-releasing hormone, together with supportive psychotherapy, may be an effective treatment for men with severe paraphilia.

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Research works printed but not linked: 10

  1. Kutchinsky B, 1985, Comp Soc Res, 8, 301
  2. Abel GG. Paraphilias. In Kaplan HI, Sadock BJ, eds. Comprehensive textbook of psychiatry/V. 5th ed. Vol. 1. Baltimore: Williams & Wilkins, 1989:1069-85.
  3. Stein DJ, 1992, J Clin Psychiatry, 53, 267
  4. Meyer WJ, 1992, Bull Am Acad Psychiatry Law, 20, 249
  5. Conn PM, 1990, N Engl J Med, 324, 93
  6. Zachmann M, 1974, Helv Pediatr Acta, 29, 61
  7. Hirsch D, 1994, Isr J Med Sci, 30, 238
  8. Allolio B, 1985, Dtsch Med Wochenschr, 110, 1952
  9. Moss RL, Dudley CA. Luteinizing hormone-releasing hormone (LHRH): peptidergic signals in the neural integration of female reproductive behavior. In: Lakoski JM, Perez-Polo JR, Rassin DK, eds. Neural control of reproductive function. Vol. 50 of Neurology and neurobiology. New York: Alan R. Liss, 1989:485-99.
  10. 10.1210/jc.76.2.288 · DOI

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Metadata

Authors
Rösler, A., & Witztum, E.
Affiliations
  • Hebrew University of Jerusalem (IL)
  • Ben-Gurion University of the Negev (IL)
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1998-02-12
Volume
338
Issue
7
Pages
416-422
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199802123380702
OpenAlex
W2616481757
Cited by
217
References
33
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 11 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 6 · 2013: 14 · 2012: 6
FWCI
13.87
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
paraphilias, pedophilia, triptorelin, GnRH agonist, testosterone suppression, sexual deviance, supportive therapy, erectile dysfunction, hot flashes, bone mineral density, treatment efficacy
MeSH terms
Adult, Follicle Stimulating Hormone, Humans, Erectile Dysfunction, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Male, Paraphilic Disorders, Testis, Testosterone, Bone Density, Treatment Outcome, Triptorelin Pamoate

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