CoChat
Sign Up
Cited by 4,032Cardiovascular Health and Risk FactorsLipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults

Open access
Berenson, Gerald S., Srinivasan, Sathanur R., Bao, Weihang, Newman, William P., Tracy, Richard E., Wattigney, Wendy A.·1998·New England Journal of Medicine
DOI 10.1056/nejm199806043382302
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: In adults, cardiovascular risk factors reinforce each other in their effect on cardiovascular events. However, information is scant on the relation of multiple risk factors to the extent of asymptomatic atherosclerosis in young people. METHODS: We performed autopsies on 204 young persons 2 to 39 years of age, who had died from various causes, principally trauma. Data on antemortem risk factors were available for 93 of these persons, who were the focus of this study. We correlated risk factors with the extent of atherosclerosis in the aorta and coronary arteries. RESULTS: The extent of fatty streaks and fibrous plaques in the aorta and coronary arteries increased with age. The association between fatty streaks and fibrous plaques was much stronger in the coronary arteries (r=0.60, P<0.001) than in the aorta (r=0.23, P=0.03). Among the cardiovascular risk factors, body-mass index, systolic and diastolic blood pressure, and serum concentrations of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol, as a group, were strongly associated with the extent of lesions in the aorta and coronary arteries (canonical correlation [a measure of the association between groups of variables]: r=0.70; P<0.001). In addition, cigarette smoking increased the percentage of the intimal surface involved with fibrous plaques in the aorta (1.22 percent in smokers vs. 0.12 percent in nonsmokers, P=0.02) and fatty streaks in the coronary vessels (8.27 percent vs. 2.89 percent, P=0.04). The effect of multiple risk factors on the extent of atherosclerosis was quite evident. Subjects with 0, 1, 2, and 3 or 4 risk factors had, respectively, 19.1 percent, 30.3 percent, 37.9 percent, and 35.0 percent of the intimal surface covered with fatty streaks in the aorta (P for trend=0.01). The comparable figures for the coronary arteries were 1.3 percent, 2.5 percent, 7.9 percent, and 11.0 percent, respectively, for fatty streaks (P for trend=0.01) and 0.6 percent, 0.7 percent, 2.4 percent, and 7.2 percent for collagenous fibrous plaques (P for trend=0.003). CONCLUSIONS: These findings indicate that as the number of cardiovascular risk factors increases, so does the severity of asymptomatic coronary and aortic atherosclerosis in young people.

Overview

Integrity signals

Registry

Crossref · 10.1056/nejm199806043382302

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 30 references

Research works printed but not linked: 4

  1. 10.1001/archinte.154.16.1842 · DOI
  2. Srinivasan SR, Berenson GS. Serum lipoproteins in children and methods for study. In: Lewis LA, ed. CRC handbook of electrophoresis. Vol. 3. Lipoprotein methodology and human studies. Boca Raton, Fla.: CRC Press, 1983:185-203.
  3. Guzman MA, 1968, Lab Invest, 18, 479
  4. Tejada C, 1968, Lab Invest, 18, 509

Cited by

Sorted by citations

Items 201–300 of 1,007

Related

See all

Metadata

Authors
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A.
Affiliations
  • Tulane University (US)
  • Louisiana State University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1998-06-04
Volume
338
Issue
23
Pages
1650-1656
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm199806043382302
OpenAlex
W2315613231
Cited by
4,032
References
30
Citations by year
2026: 89 · 2025: 70 · 2024: 101 · 2023: 144 · 2022: 142 · 2021: 130 · 2020: 143 · 2019: 130 · 2018: 162 · 2017: 147 · 2016: 159 · 2015: 201 · 2014: 222 · 2013: 241 · 2012: 228
FWCI
46.44
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL 38 844)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 32 194, R01HD032194)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
cardiovascular risk factors, atherosclerosis, young adults, children, fatty streaks, fibrous plaque, aorta, coronary arteries, body mass index, blood pressure, serum lipids, cigarette smoking, multiple risk factors, autopsy findings, coronary heart disease risk
MeSH terms
Adolescent, Adult, Aorta, Aortic Diseases, Arteriosclerosis, Blood Pressure, Cardiovascular Diseases, Child, Child, Preschool, Coronary Artery Disease, Coronary Vessels, Female, Humans, Lipids, Louisiana, Male, Risk Factors, Smoking, Body Mass Index, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review