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A Comparison of Noninvasive Positive-Pressure Ventilation and Conventional Mechanical Ventilation in Patients with Acute Respiratory Failure
Open accessAbstract
BACKGROUND AND METHODS: The role of noninvasive positive-pressure ventilation delivered through a face mask in patients with acute respiratory failure is uncertain. We conducted a prospective, randomized trial of noninvasive positive-pressure ventilation as compared with endotracheal intubation with conventional mechanical ventilation in 64 patients with hypoxemic acute respiratory failure who required mechanical ventilation. RESULTS: Within the first hour of ventilation, 20 of 32 patients (62 percent) in the noninvasive-ventilation group and 15 of 32 (47 percent) in the conventional-ventilation group had an improved ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen (PaO2:FiO2) (P=0.21). Ten patients in the noninvasive-ventilation group subsequently required endotracheal intubation. Seventeen patients in the conventional-ventilation group (53 percent) and 23 in the noninvasive-ventilation group (72 percent) survived their stay in the intensive care unit (odds ratio, 0.4; 95 percent confidence interval, 0.1 to 1.4; P=0.19); 16 patients in the conventional-ventilation group and 22 patients in the noninvasive-ventilation group were discharged from the hospital. More patients in the conventional-ventilation group had serious complications (66 percent vs. 38 percent, P=0.02) and had pneumonia or sinusitis related to the endotracheal tube (31 percent vs. 3 percent, P=0.003). Among the survivors, patients in the noninvasive-ventilation group had shorter periods of ventilation (P=0.006) and shorter stays in the intensive care unit (P=0.002). CONCLUSIONS: In patients with acute respiratory failure, noninvasive ventilation was as effective as conventional ventilation in improving gas exchange and was associated with fewer serious complications and shorter stays in the intensive care unit.
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“A few small RCTs have shown benefit with NIV for early or mild ARDS or de novo hypoxic respiratory failure [418, 419].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [418]
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Metadata
- Authors
- Antonelli, M., Conti, G., Rocco, M., Bufi, M., De Blasi, R. A., Vivino, G., Gasparetto, A., & Meduri, G. U.
- Affiliations
- Policlinico Umberto I (IT)
- University of Tennessee Health Science Center (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1998-08-13
- Volume
- 339
- Issue
- 7
- Pages
- 429-435
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2331306740
- Cited by
- 1,014
- References
- 27
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 38 · 2021: 29 · 2020: 28 · 2019: 25 · 2018: 32 · 2017: 35 · 2016: 32 · 2015: 38 · 2014: 27 · 2013: 32 · 2012: 24
- FWCI
- 50.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- noninvasive positive pressure ventilation, acute respiratory failure, hypoxemic respiratory failure, endotracheal intubation, mechanical ventilation, PaO2/FiO2 ratio, ventilator-associated pneumonia, ICU length of stay, ventilator complications, mask ventilation
- MeSH terms
- Acute Disease, Aged, Female, Humans, Intensive Care Units, Intubation, Intratracheal, Length of Stay, Male, Masks, Middle Aged, Oxygen, Positive-Pressure Respiration, Prospective Studies, Pulmonary Gas Exchange, Respiration, Artificial, Respiratory Insufficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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