The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
Abstract
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American-European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.
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Another RCT did not find an effect on mortality with gelatin use (RR, 0.87; 95% CI, 0.66-1.12).
“Similarly, another RCT did not find an effect on mortality with gelatin use (RR, 0.87; 95% CI, 0.66-1.12)(344).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [344]
The studies that guide the recommendations in this section enrolled patients using criteria from the American-European Consensus Criteria Definition for Acute Lung Injury and ARDS.
“Of note, the studies that guide the recommendations in this section enrolled patients using criteria from the American-European Consensus Criteria Definition for Acute Lung Injury and ARDS [422].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [422]
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- Authors
- Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R.
- Affiliations
- Vanderbilt University (US)
- Vanderbilt University, Nashville, Tennessee
- Venue
- American journal of respiratory and critical care medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-03-01
- Volume
- 149
- Issue
- 3
- Pages
- 818-824
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2161328469
- Cited by
- 6,746
- References
- 20
- Citations by year
- 2026: 54 · 2025: 112 · 2024: 107 · 2023: 119 · 2022: 126 · 2021: 164 · 2020: 158 · 2019: 184 · 2018: 156 · 2017: 192 · 2016: 238 · 2015: 241 · 2014: 289 · 2013: 341 · 2012: 364
- FWCI
- 80.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl043167-05, 5p50hl019153-22)
- National Heart, Lung, and Blood Institute (NHLBI HL19153, NHLBI HL43167)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- acute respiratory distress syndrome, ARDS definition, ARDS pathophysiology, ARDS incidence, ARDS mortality, clinical trial coordination
- MeSH terms
- Americas, Clinical Protocols, Clinical Trials as Topic, Europe, Humans, Oxygen Inhalation Therapy, Prognosis, Radiography, Respiratory Distress Syndrome, Risk Factors, Incidence, Prevalence
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