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Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs
Abstract
One hundred years have passed since Felix Hoffman, working at Bayer Industries, reported the successful synthesis of acetylsalicylic acid as the first nonsteroidal antiinflammatory drug (NSAID).1,2 At the suggestion of Hermann Dreser, Bayer's chief pharmacologist at the time,3 the compound was called “aspirin” and was purported to represent a convenient mechanism for the delivery of salicylic acid in the treatment of rheumatic diseases, menstrual pain, and fever.2 Approximately 40 years elapsed before Douthwaite and Lintott4 provided endoscopic evidence that aspirin could cause gastric mucosal damage. Numerous reports have corroborated this observation,58 and the introduction of more potent agents . . .
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Cited by
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The role of COX‐2 in intestinal inflammation and colorectal cancer
Wang, D., & DuBois, R. N. (2010) · Oncogene · doi:10.1038/onc.2009.421 · Cited by 805
Ong, C. K. S., Seymour, R. A., Lirk, P., & Merry, A. F. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181cf9281 · Cited by 631
Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609
Diclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Metadata
- Authors
- Wolfe, M. M., Lichtenstein, D. R., & Singh, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1999-06-17
- Volume
- 340
- Issue
- 24
- Pages
- 1888-1899
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1981816788
- Cited by
- 1,956
- References
- 0
- FWCI
- 57.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wolfe, M. M., Lichtenstein, D. R., & Singh, G. (1999). Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs. New England Journal of Medicine. https://doi.org/10.1056/nejm199906173402407
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
