Cited by 2,489Cardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studiesCardiac Arrhythmias and Treatments

The DOI matches its Crossref record, with a small difference in title or year; 34 of the 34 references it cites were found in a registry or an index.

A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

Open access

Buxton, Alfred E., Lee, Kerry L., Fisher, John D., Josephson, Mark E., Prystowsky, Eric N., Hafley, Gail·1999·New England Journal of Medicine

DOI 10.1056/nejm199912163412503

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death. METHODS: We conducted a randomized, controlled trial to test the hypothesis that electrophysiologically guided antiarrhythmic therapy would reduce the risk of sudden death among patients with coronary artery disease, a left ventricular ejection fraction of 40 percent or less, and asymptomatic, unsustained ventricular tachycardia. Patients in whom sustained ventricular tachyarrhythmias were induced by programmed stimulation were randomly assigned to receive either antiarrhythmic therapy, including drugs and implantable defibrillators, as indicated by the results of electrophysiologic testing, or no antiarrhythmic therapy. Angiotensin-converting-enzyme inhibitors and beta-adrenergic-blocking agents were administered if the patients could tolerate them. RESULTS: A total of 704 patients with inducible, sustained ventricular tachyarrhythmias were randomly assigned to treatment groups. Five-year Kaplan-Meier estimates of the incidence of the primary end point of cardiac arrest or death from arrhythmia were 25 percent among those receiving electrophysiologically guided therapy and 32 percent among the patients assigned to no antiarrhythmic therapy (relative risk, 0.73; 95 percent confidence interval, 0.53 to 0.99), representing a reduction in risk of 27 percent). The five-year estimates of overall mortality were 42 percent and 48 percent, respectively (relative risk, 0.80; 95 percent confidence interval, 0.64 to 1.01). The risk of cardiac arrest or death from arrhythmia among the patients who received treatment with defibrillators was significantly lower than that among the patients discharged without receiving defibrillator treatment (relative risk, 0.24; 95 percent confidence interval, 0.13 to 0.45; P<0.001). Neither the rate of cardiac arrest or death from arrhythmia nor the overall mortality rate was lower among the patients assigned to electrophysiologically guided therapy and treated with antiarrhythmic drugs than among the patients assigned to no antiarrhythmic therapy. CONCLUSIONS: Electrophysiologically guided antiarrhythmic therapy with implantable defibrillators, but not with antiarrhythmic drugs, reduces the risk of sudden death in high-risk patients with coronary disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejm199912163412503

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875
Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia
Moss, A. J., Hall, W. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Klein, H., Levine, J. H., Saksena, S., Waldo, A. L., Wilber, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612263352601 · Cited by 4,165
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo
Echt, D. S., Liebson, P. R., Mitchell, L. B., Peters, R. W., Obias-Manno, D., Barker, A. H., Arensberg, D., Baker, A., Friedman, L., Greene, H. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199103213241201 · Cited by 3,244
A Comparison of Antiarrhythmic-Drug Therapy with Implantable Defibrillators in Patients Resuscitated from Near-Fatal Ventricular Arrhythmias
The AVID Investigators (1997) · New England Journal of Medicine · doi:10.1056/nejm199711273372202 · Cited by 3,221
Discrete Sequential Boundaries for Clinical Trials
Lan, K. K. G., & DeMets, D. L. (1983) · Biometrika · doi:10.2307/2336502 · Cited by 2,310
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
Julian, D. G., CAMM, A. J., Frangin, G., Janse, M. J., Munoz, A., Pj, S., & Simon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09145-3 · Cited by 1,100
Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT
Cairns, J. A., Connolly, S. J., Roberts, R. E., & Gent, M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)08171-8 · Cited by 949
Out-of-Hospital Cardiac Arrest in the 1990s: A Population-Based Study in the Maastricht Area on Incidence, Characteristics and Survival
de Vreede-Swagemakers, J. J. M., Gorgels, A. P. M., Dubois-Arbouw, W. I., van Ree, J. W., Daemen, M. J. A. P., Houben, L. G. E., & Wellens, H. J. J. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00355-0 · Cited by 841
Clinical classification of cardiac deaths.
Hinkle, L. E., & Thaler, H. T. (1982) · Circulation · doi:10.1161/01.cir.65.3.457 · Cited by 640
Use of the Automatic External Defibrillator in the Management of Out-of-Hospital Cardiac Arrest
Weaver, W. D., Hill, D., Fahrenbruch, C. E., Copass, M. K., Martin, J. S., Cobb, L. A., & Hallstrom, A. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809153191101 · Cited by 473
Prehospital Ventricular Defibrillation
Liberthson, R. R., Nagel, E. L., Hirschman, J. C., & Nussenfeld, S. R. (1974) · New England Journal of Medicine · doi:10.1056/nejm197408152910701 · Cited by 472
Prognostic significance of ventricular tachycardia and fibrillation induced at programmed stimulation and delayed potentials detected on the signal-averaged electrocardiograms of survivors of acute myocardial infarction.
Denniss, A. R., Richards, D. A., Cody, D. V., Russell, P. A., Young, A. A., Cooper, M. J., Ross, D. L., & Uther, J. B. (1986) · Circulation · doi:10.1161/01.cir.74.4.731 · Cited by 450
Racial Differences in the Incidence of Cardiac Arrest and Subsequent Survival
Becker, L. B., Han, B. H., Meyer, P., Wright, F. A., Rhodes, K. V., Smith, D. W., & Barrett, J. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199308263290902 · Cited by 441
Electrophysiological testing and nonsustained ventricular tachycardia. Use and limitations in patients with coronary artery disease and impaired ventricular function.
Wilber, D. J., Olshansky, B., Moran, J. F., & Scanlon, P. J. (1990) · Circulation · doi:10.1161/01.cir.82.2.350 · Cited by 274
Myocardial infarction patients in the 1990s—their risk factors, stratification and survival in Canada: The Canadian assessment of myocardial infarction (CAMI) study
Rouleau, J. L., Talajic, M. R., Sussex, B. A., Potvin, L., Warnica, W. J., Davies, R. F., Gardner, M., Stewart, D. J., Planté, S., Dupuis, R., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00599-4 · Cited by 268
Long-term benefit of early thrombolytic therapy in patients with acute myocardial infarction: 5 year follow-up of a trial conducted by the Interuniversity Cardiology Institute of the Netherlands
Simoons, M. L., Vos, J., Tijssen, J. G. P., Vermeer, F., Verheugt, F. W. A., Krauss, X. H., & Cats, V. M. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90003-x · Cited by 220
Prevention of sudden death in patients with coronary artery disease: The multicenter unsustained tachycardia trial (MUSTT)
Buxton, A. E., Fisher, J. D., Josephson, M. E., Lee, K. L., Pryor, D. B., Prystowsky, E. N., Simson, M. B., DiCarlo, L. A., Echt, D. S., Packer, D. L., et al. (1993) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(93)90015-6 · Cited by 180
Self-citation
Programmed electrical stimulation in patients with high-grade ventricular ectopy: electrophysiologic findings and prognosis for survival.
Gomes, J. A., Hariman, R. I., Kang, P. S., El-Sherif, N., Chowdhry, I. H., & Lyons, J. (1984) · Circulation · doi:10.1161/01.cir.70.1.43 · Cited by 165
Routine programmed electrical stimulation in survivors of acute myocardial infarction for prediction of spontaneous ventricular tachyarrhythmias during follow-up: Results, optimal stimulation protocol and cost-effective screening
Bourke, J. P., Richards, D. A. B., Ross, D. L., Wallace, E. M., McGuire, M. A., & Uther, J. B. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90802-g · Cited by 161
Programmed ventricular stimulation in survivors of an acute myocardial infarction.
Roy, D., Marchand, E., Théroux, P., Waters, D. D., Pelletier, G. B., & Bourassa, M. G. (1985) · Circulation · doi:10.1161/01.cir.72.3.487 · Cited by 142
Nonsustained ventricular tachycardia in patients with coronary artery disease: role of electrophysiologic study.
Buxton, A. E., Marchlinski, F. E., Flores, B. T., Miller, J. M., Doherty, J. U., & Josephson, M. E. (1987) · Circulation · doi:10.1161/01.cir.75.6.1178 · Cited by 131
Self-citation
Long-term survival in 618 patients from the Western Washington streptokinase in myocardial infarction trials
Cerqueira, M. D., Maynard, C. C., Ritchie, J. L., Davis, K. B., & Kennedy, J. W. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90436-q · Cited by 104
Prevalence, characteristics and significance of ventricular premature complexes and ventricular tachycardia detected by 24-hour continuous electrocardiographic recording in the Cardiac Arrhythmia Suppression Trial
Denes, P., Gillis, A. M., Yudi Pawitan, Y., Kammerling, J. M., Wilhelmsen, L., Salerno, D. M., & The CAST Investigators (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90404-9 · Cited by 71
Prediction of Sustained Ventricular Tachycardia Inducible by Programmed Stimulation in Patients With Coronary Artery Disease
Buxton, A. E., Hafley, G. E., Lehmann, M. H., Gold, M. R., O’Toole, M., Tang, A., Coromilas, J., Hook, B. G., Stamato, N. J., & Lee, K. L. (1999) · Circulation · doi:10.1161/01.cir.99.14.1843 · Cited by 70
Self-citation
Prognostic significance of sustained monomorphic ventricular tachycardia induced by programmed ventricular stimulation using up to triple extrastimuli in survivors of acute myocardial infarction
Iesaka, Y., Nogami, A., Aonuma, K., Nitta, J., Chun, Y., Fujiwara, H., & Hiraoka, M. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90314-q · Cited by 61
Does the rest electrocardiogram after myocardial infarction determine the predictive value of exercise-induced st depression? A 2 year follow-up study in a veteran population
Klein, J., Froelicher, V. F., Detrano, R., Dubach, P., & Yen, R. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90178-2 · Cited by 52
Nonsustained Ventricular Tachycardia in Coronary Artery Disease: Relation to Inducible Sustained Ventricular Tachycardia
Buxton, A. E., Lee, K. L., DiCarlo, L., Echt, D. S., Fisher, J. D., Greer, G. S., Josephson, M. E., Packer, D., Prystowsky, E. N., Talajic, M. R., et al. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-125-1-199607010-00006 · Cited by 50
Self-citation
Remarks About Postinfarction Prognosis in Light of the Experience With the Gruppo Italiano per lo Studio della Sopravvivenza nell' Infarto Miocardico (GISSI) Trials
Tavazzi, L., & Volpi, A. (1997) · Circulation · doi:10.1161/01.cir.95.5.1341 · Cited by 44
Definition of Predicted Effective Antiarrhythmic Drug Therapy for Ventricular Tachyarrhythmias by the Electrophysiologic Study Approach: Randomized Comparison of Patient Response Criteria
Mitchell, L. B., Sheldon, R. S., Gillis, A. M., Connolly, S. J., Duff, H. J., Gardner, M. J., Hui, W. K. K., Ramadan, D., & Wyse, D. G. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00294-5 · Cited by 23
Meta-analysis of empirical long-term antiarrhythmic therapy after myocardial infarction
Hine, L. K. (1989) · JAMA · doi:10.1001/jama.262.21.3037 · Cited by 9

Research works printed but not linked: 1

10.2307/2281868 · DOI · Paper page

Sorted by citations

2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
“symptoms while receiving GDMT, who have reasonable expectation of meaningful survival for more than 1 yeary (362,597,598).”
Background
Prophylactic Implantation of a Defibrillator in Patients with Myocardial Infarction and Reduced Ejection Fraction
Moss, A. J., Zaręba, W., Hall, W. J., Klein, H., Wilber, D. J., Cannom, D. S., Daubert, J. P., Higgins, S. L., Brown, M. W., & Andrews, M. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013474 · Cited by 6,885
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,532
2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
Zeppenfeld, K., Tfelt‐Hansen, J., Riva, M., Winkel, B. G., Behr, E. R., Blom, N. A., Charron, P., Corrado, D., Dagres, N., de Chillou, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac262 · Cited by 3,432

See all 2,489

Authors: Buxton, A. E., Lee, K. L., Fisher, J. D., Josephson, M. E., Prystowsky, E. N., & Hafley, G.
Affiliations: Brown University (US)
Duke University (US)
Albert Einstein College of Medicine (US)
Beth Israel Deaconess Medical Center (US)
ORCID: Buxton, Alfred E.
Lee, Kerry L.
Fisher, John D.
Prystowsky, Eric N.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1999-12-16
Volume: 341
Issue: 25
Pages: 1882-1890
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm199912163412503
OpenAlex: W2313547185
Cited by: 2,489
References: 34
Citations by year: 2026: 20 · 2025: 36 · 2024: 23 · 2023: 34 · 2022: 44 · 2021: 41 · 2020: 51 · 2019: 54 · 2018: 54 · 2017: 92 · 2016: 75 · 2015: 87 · 2014: 95 · 2013: 114 · 2012: 122
FWCI: 70.29
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5u01hl045726-06)
National Heart, Lung, and Blood Institute (UO1HL45700, UO1-HL45726, U01HL045700)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: coronary artery disease, asymptomatic ventricular arrhythmia, implantable cardioverter-defibrillator, antiarrhythmic drugs, electrophysiologic testing, programmed electrical stimulation, cardiac arrest, all-cause mortality, left ventricular ejection fraction, ACE inhibitors, beta-blockers
MeSH terms: Aged, Anti-Arrhythmia Agents, Cardiac Pacing, Artificial, Coronary Disease, Electrophysiology, Female, Humans, Male, Middle Aged, Survival Analysis, Death, Sudden, Cardiac, Defibrillators, Implantable, Tachycardia, Ventricular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Randomized Study of the Prevention of Sudden Death in Patients with Coronary Artery Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks