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The Physiology of Parathyroid Hormone–Related Protein
Abstract
Parathyroid hormone–related protein was identified in the 1980s as a tumor product that had the ability to activate parathyroid hormone receptors and cause hypercalcemia.1 Parathyroid hormone–related protein resembles parathyroid hormone not only in terms of its genetic sequence but also in terms of its genetic structure and is thus a second member of the parathyroid hormone family.2 As expected of a protein that activates the parathyroid hormone receptor, parathyroid hormone–related protein causes hypercalcemia by increasing bone resorption and renal tubular resorption of calcium.3,4 Like parathyroid hormone, it also has phosphaturic action.Parathyroid Hormone–Related Protein and HypercalcemiaParathyroid hormone–related protein . . .
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Citations
Cited by
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Hyperparathyroid and Hypoparathyroid Disorders
Marx, S. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432508 · Cited by 481
Hormones and Disorders of Mineral Metabolism
Bringhurst, F. R., Demay, M. B., & Kronenberg, H. M. (2011) · Williams Textbook of Endocrinology · doi:10.1016/b978-1-4377-0324-5.00028-6 · Cited by 298
Parathyroid Hormone-Related Protein: An Update
Wysolmerski, J. J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2142 · Cited by 279
Pathophysiological mechanisms of vascular calcification in end-stage renal disease
Davies, M. R., & Hruska, K. A. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.060002472.x · Cited by 259
Metadata
- Authors
- Strewler, G. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-01-20
- Volume
- 342
- Issue
- 3
- Pages
- 177-185
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341713409
- Cited by
- 439
- References
- 0
- FWCI
- 27.52
- Type
- journal article
- Language
- en
- Open access
- closed
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