The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Parathyroid Hormone-Related Protein: An Update
Open accessAbstract
PTHrP was identified as a cause of hypercalcemia in cancer patients 25 yr ago. In the intervening years, we have learned that PTHrP and PTH are encoded by related genes that are part of a larger "PTH gene family." This evolutionary relationship permits them to bind to the same type 1 PTH/PTHrP receptor, which explains why humoral hypercalcemia of malignancy resembles hyperparathyroidism. This review will outline basic facts about PTHrP biology and its normal physiological functions, with an emphasis on new findings of the past 5-10 yr. The medical and research communities first became aware of PTHrP because of its involvement in a common paraneoplastic syndrome. Now, research into the basic biology of PTHrP has suggested previously unrecognized connections to a variety of disease states such as osteoporosis, osteoarthritis, and breast cancer and has highlighted how PTHrP itself might be used in therapy for osteoporosis and diabetes. Therefore, the story of this remarkable protein is a paradigm for translational research, having gone from bedside to bench and now back to bedside.
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Citations
Cites
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A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression
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Defining the roles of parathyroid hormone-related protein in normal physiology
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PTHrP and Skeletal Development
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Cited by
Osteocytic signalling pathways as therapeutic targets for bone fragility
Plotkin, L. I., & Bellido, T. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.71 · Cited by 206
Delgado-Calle, J., Tu, X., Pacheco-Costa, R., McAndrews, K., Edwards, R., Pellegrini, G. G., Kuhlenschmidt, K., Olivos, N., Robling, A., Peacock, M., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3011 · Cited by 114
Metadata
- Authors
- Wysolmerski, J. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2012-09-01
- Volume
- 97
- Issue
- 9
- Pages
- 2947-2956
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2025075383
- Cited by
- 279
- References
- 73
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wysolmerski, J. J. (2012). Parathyroid Hormone-Related Protein: An Update. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2012-2142
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
