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Neurologic Complications of the Reactivation of Varicella–Zoster Virus
Abstract
Varicella–zoster virus is an exclusively human herpesvirus that causes chickenpox (varicella), becomes latent in cranial-nerve and dorsal-root ganglia, and frequently reactivates decades later to produce shingles (zoster) and postherpetic neuralgia. In immunocompetent elderly persons or immunocompromised patients, varicella–zoster virus may produce disease of the central nervous system.Since the last major review of varicella–zoster virus in the Journal, 1,2 advances in molecular biology have provided important new insights into the pathogenesis of infection with varicella–zoster virus. The detection of varicella–zoster virus in blood vessels and other tissues by methods based on the polymerase chain reaction (PCR) has widened the recognized . . .
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Cited by
Recommendations for the management of herpes zoster
Dworkin, R. H., Johnson, R. W., Breuer, J., Gnann, J. W., Levin, M. J., Backonja, M., Betts, R. F., Gershon, A. A., Haanpää, M. L., McKendrick, M. W., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/510206 · Cited by 869
Crucian, B. E., Choukèr, A., Simpson, R. J., Mehta, S., Marshall, G., Smith, S. M., Zwart, S. R., Heer, M., Ponomarev, S., Whitmire, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01437 · Cited by 421
Varicella‐Zoster Virus: Atypical Presentations and Unusual Complications
Gnann, Jr. (2002) · The Journal of Infectious Diseases · doi:10.1086/342963 · Cited by 396
Viral encephalitis: a review of diagnostic methods and guidelines for management
Steiner, I., Budka, H., Chaudhuri, A., Koskiniemi, M., Sainio, K., Salonen, O., & Kennedy, P. G. E. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01126.x · Cited by 367
Levin, M. J., Smith, J. G., Kaufhold, R. M., Barber, D., Hayward, A. R., Chan, C. Y., Chan, I. S. F., Li, D. J. J., Wang, W., Keller, P. M., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/379048 · Cited by 314
Metadata
- Authors
- Gilden, D. H., Kleinschmidt-DeMasters, B. K., LaGuardia, J. J., Mahalingam, R., & Cohrs, R. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-03-02
- Volume
- 342
- Issue
- 9
- Pages
- 635-645
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2321123402
- Cited by
- 853
- References
- 0
- FWCI
- 22.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neurologic Complications of the Reactivation of Varicella–Zoster Virus. https://app.cochat.ai/papers/10.1056/nejm200003023420906
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- Gilden, D. H., Kleinschmidt-DeMasters, B. K., LaGuardia, J. J., Mahalingam, R., & Cohrs, R. J. (2000). Neurologic Complications of the Reactivation of Varicella–Zoster Virus. New England Journal of Medicine. https://doi.org/10.1056/nejm200003023420906
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