The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling
Open accessAbstract
BACKGROUND: Umbilical-cord blood as an alternative to bone marrow for hematopoietic stem-cell transplantation may lower the risk of graft-versus-host disease (GVHD). METHODS: We studied the records of 113 recipients of cord blood from HLA-identical siblings from the period from 1990 through 1997 and compared them with the records of 2052 recipients of bone marrow from HLA-identical siblings during the same period. The study population consisted of children 15 years of age or younger. We compared the rates of GVHD, hematopoietic recovery, and survival using Cox proportional-hazards regression to adjust for potentially confounding factors. RESULTS: Recipients of cord blood were younger than recipients of bone marrow (median age, 5 years vs. 8 years; P<0.001), weighed less (median weight, 17 kg vs. 26 kg; P<0.001), and were less likely to have received methotrexate for prophylaxis against GVHD (28 percent vs. 65 percent, P<0.001). Multivariate analysis demonstrated a lower risk of acute GVHD (relative risk, 0.41; P=0.001) and chronic GVHD (relative risk, 0.35; P=0.02) among recipients of cord-blood transplants. As compared with recovery after bone marrow transplantation, the likelihood of recovery of the neutrophil count and the platelet count was significantly lower in the first month after cord-blood transplantation (relative risk, 0.40 [P<0.001], and relative risk, 0.20 [P<0.001]), respectively. Mortality was similar in the two groups (relative risk of death in the recipients of cord blood, 1.15; P=0.43). CONCLUSIONS: Recipients of cord-blood transplants from HLA-identical siblings have a lower incidence of acute and chronic GVHD than recipients of bone marrow transplants from HLA-identical siblings.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
GLUCKSBERG, H., STORB, R., FEFER, A., BUCKNER, C. D., NEIMAN, P. E., CLIFT, R. A., LERNER, K. G., & THOMAS, E. D. (1974) · Transplantation · doi:10.1097/00007890-197410000-00001 · Cited by 3,694
Survival Analysis, Techniques for Censored and Truncated Data
Rao, M. B. (1998) · Technometrics · doi:10.1080/00401706.1998.10485206 · Cited by 3,617
Gooley, T. A., Leisenring, W., Crowley, J., & Storer, B. E. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19990330)18:6<695::aid-sim60>3.0.co;2-o · Cited by 2,688
Gluckman, E., Broxmeyer, H. E., Auerbach, A. D., Friedman, H. S., Douglas, G. W., Devergie, A., Esperou, H., Thierry, D., Socie, G., Lehn, P., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910263211707 · Cited by 2,094
Self-citationOutcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors
Rubinstein, P., Carrier, C., Scaradavou, A., Kurtzberg, J., Adamson, J., Migliaccio, A. R., Berkowitz, R. L., Cabbad, M., Dobrila, N. L., Taylor, P. E., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811263392201 · Cited by 1,319
Outcome of Cord-Blood Transplantation from Related and Unrelated Donors
Gluckman, E., Rocha, V., Boyer-Chammard, A., Locatelli, F., Arcese, W., Pasquini, R., Ortega, J., Souillet, G., Ferreira, E., Laporte, J.-P., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708073370602 · Cited by 1,249
Self-citationKurtzberg, J., Laughlin, M., Graham, M. L., Smith, C., Olson, J. F., Halperin, E. C., Ciocci, G., Carrier, C., Stevens, C. E., & Rubinstein, P. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607183350303 · Cited by 1,024
Klein, J. P., & Moeschberger, M. L. (1997) · Statistics for Biology and Health · doi:10.1007/978-1-4757-2728-9 · Cited by 685
Self-citationWagner, J., Rosenthal, J., Sweetman, R., Shu, X., Davies, S., Ramsay, N., McGlave, P., Sender, L., & Cairo, M. (1996) · Blood · doi:10.1182/blood.v88.3.795.795 · Cited by 629
Self-citationWagner, J., Steinbuch, M., Kernan, N., Broxmayer, H., & Gluckman, E. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91268-1 · Cited by 587
Self-citation
Cited by
Wagner, J. E., Barker, J. N., DeFor, T. E., Baker, K. S., Blazar, B. R., Eide, C., Goldman, A., Kersey, J., Krivit, W., MacMillan, M. L., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0294 · Cited by 1,010
Self-citationUmbilical cord blood transplantation: the first 25 years and beyond
Ballen, K. K., Gluckman, E., & Broxmeyer, H. E. (2013) · Blood · doi:10.1182/blood-2013-02-453175 · Cited by 709
Self-citationFactors affecting thymic function after allogeneic hematopoietic stem cell transplantation
Weinberg, K., Blazar, B. R., Wagner, J. E., Agura, E., Hill, B. J., Smogorzewska, M., Koup, R. A., Betts, M. R., Collins, R. H., & Douek, D. C. (2001) · Blood · doi:10.1182/blood.v97.5.1458 · Cited by 422
Self-citationRelated umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
Locatelli, F. (2003) · Blood · doi:10.1182/blood-2002-07-2090 · Cited by 386
Human NK cells display major phenotypic and functional changes over the life span
Le Garff‐Tavernier, M., Béziat, V., Decocq, J., Siguret, V., Gandjbakhch, F., Pautas, E., Debré, P., Merle‐Beral, H., & Vieillard, V. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00584.x · Cited by 338
Metadata
- Authors
- Rocha, V., Wagner, J. E., Sobocinski, K. A., Klein, J. P., Zhang, M.-J., Horowitz, M. M., & Gluckman, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-06-22
- Volume
- 342
- Issue
- 25
- Pages
- 1846-1854
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2127340198
- Cited by
- 868
- References
- 17
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling. https://app.cochat.ai/papers/10.1056/nejm200006223422501
- The paper
- Rocha, V., Wagner, J. E., Sobocinski, K. A., Klein, J. P., Zhang, M.-J., Horowitz, M. M., & Gluckman, E. (2000). Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling. New England Journal of Medicine. https://doi.org/10.1056/nejm200006223422501
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
