The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers
Open accessAbstract
BACKGROUND: After endoscopic treatment of bleeding peptic ulcers, bleeding recurs in 15 to 20 percent of patients. METHODS: We assessed whether the use of a high dose of a proton-pump inhibitor would reduce the frequency of recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Patients with actively bleeding ulcers or ulcers with nonbleeding visible vessels were treated with an epinephrine injection followed by thermocoagulation. After hemostasis had been achieved, they were randomly assigned in a double-blind fashion to receive omeprazole (given as a bolus intravenous injection of 80 mg followed by an infusion of 8 mg per hour for 72 hours) or placebo. After the infusion, all patients were given 20 mg of omeprazole orally per day for eight weeks. The primary end point was recurrent bleeding within 30 days after endoscopy. RESULTS: We enrolled 240 patients, 120 in each group. Bleeding recurred within 30 days in 8 patients (6.7 percent) in the omeprazole group, as compared with 27 (22.5 percent) in the placebo group (hazard ratio, 3.9; 95 percent confidence interval, 1.7 to 9.0). Most episodes of recurrent bleeding occurred during the first three days, which made up the infusion period (5 in the omeprazole group and 24 in the placebo group, P<0.001). Three patients in the omeprazole group and nine in the placebo group underwent surgery (P=0.14). Five patients (4.2 percent) in the omeprazole group and 12 (10 percent) in the placebo group died within 30 days after endoscopy (P=0.13). CONCLUSIONS: After endoscopic treatment of bleeding peptic ulcers, a high-dose infusion of omeprazole substantially reduces the risk of recurrent bleeding.
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Citations
Cites
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Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
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Self-citationEffect of acid and pepsin on blood coagulation and platelet aggregation
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A Comparison of Omeprazole and Placebo for Bleeding Peptic Ulcer
Khuroo, M. S., Yattoo, G. N., Javid, G., Khan, B. A., Shah, A. A., Gulzar, G. M., & Sodi, J. S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361503 · Cited by 359
Cited by
Barkun, A. N., Bardou, M., Kuipers, E. J., Sung, J., Hunt, R. H., Martel, M., Sinclair, P., & for the International Consensus Upper Gastrointestinal Bleeding Conference Group* (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00009 · Cited by 1,163
Self-citationvan Leerdam, M. E., Vreeburg, E. M., Rauws, E. A. J., Geraedts, A. A. M., Tijssen, J. G. P., Reitsma, J. B., & Tytgat, G. N. J. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07517.x · Cited by 508
Epidemiology of acute upper gastrointestinal bleeding
van Leerdam, M. E. (2008) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2007.10.011 · Cited by 455
Non-variceal upper gastrointestinal haemorrhage: guidelines
(2002) · Gut · doi:10.1136/gut.51.suppl_4.iv1 · Cited by 261
McDonald, E. G., Milligan, J., Frenette, C., & Lee, T. C. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.42 · Cited by 216
Metadata
- Authors
- Lau, J. Y. W., Sung, J. J. Y., Lee, K. K. C., Yung, M.-Y., Wong, S. K. H., Wu, J. C. Y., Chan, F. K. L., Ng, E. K. W., You, J. H. S., Lee, C. W., Chan, A. C. W., & Chung, S. C. S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-08-03
- Volume
- 343
- Issue
- 5
- Pages
- 310-316
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1964067924
- Cited by
- 699
- References
- 26
- FWCI
- 49.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lau, J. Y. W., Sung, J. J. Y., Lee, K. K. C., Yung, M.-Y., Wong, S. K. H., Wu, J. C. Y., Chan, F. K. L., Ng, E. K. W., You, J. H. S., Lee, C. W., Chan, A. C. W., & Chung, S. C. S. (2000). Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers. New England Journal of Medicine. https://doi.org/10.1056/nejm200008033430501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
