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Defective Urinary Concentrating Ability Due to a Complete Deficiency of Aquaporin-1
Open accessAbstract
Aquaporin-1, the archetypal water-channel protein,1 was initially identified in red cells and renal proximal tubular epithelium.2 The gene for aquaporin-1 (AQP1) on chromosome 7 colocalizes with the Colton blood-group antigen,3,4 and the Colton blood-group antigen polymorphism was identified as a substitution of a single amino acid in an extracellular domain of aquaporin-1.5 The International Blood Group Reference Laboratory has confirmed the existence of only six kindreds who lack the Colton blood group. Members of three of these kindreds were found to be homozygous for different mutations in the AQP1 gene, and their red-cell membranes had a complete . . .
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Cited by
Aquaporins in the Kidney: From Molecules to Medicine
Nielsen, S., Frøkiær, J., Marples, D., Kwon, T.-H., Agre, P., & Knepper, M. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00024.2001 · Cited by 1,251
Self-citationAquaporins: important but elusive drug targets
Verkman, A. S., Anderson, M. O., & Papadopoulos, M. C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4226 · Cited by 586
Aquaporin water channels: molecular mechanisms for human diseases1
Agre, P., & Kozono, D. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01083-4 · Cited by 490
Self-citationAquaporins in Clinical Medicine
Verkman, A. S. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-043010-193843 · Cited by 388
Functional requirement of aquaporin-5 in plasma membranes of sweat glands
Nejsum, L. N., Kwon, T.-H., Jensen, U. B., Fumagalli, O., Frøkiaer, J., Krane, C. M., Menon, A. G., King, L. S., Agre, P. C., & Nielsen, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012588099 · Cited by 211
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Metadata
- Authors
- King, L. S., Choi, M., Fernandez, P. C., Cartron, J.-P., & Agre, P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2001-07-19
- Volume
- 345
- Issue
- 3
- Pages
- 175-179
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1995178724
- Cited by
- 230
- References
- 0
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- King, L. S., Choi, M., Fernandez, P. C., Cartron, J.-P., & Agre, P. (2001). Defective Urinary Concentrating Ability Due to a Complete Deficiency of Aquaporin-1. New England Journal of Medicine. https://doi.org/10.1056/nejm200107193450304
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