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LRRK2 G2019S as a Cause of Parkinson's Disease in North African Arabs
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G2019S-LRRK2 accounts for 30-41% of familial Parkinson's disease cases and 10% of sporadic Parkinson's disease.
“The G2019S-LRRK2 mutations accounts for 30–41% of all familial cases, and 10% of sporadic PD [23, 31, 38, 39, 57, 58, 68, 99].”
From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [38]
Table 1 reports 30% and 41% in separate studies of familial Parkinson’s disease among North African Arabs, supporting that range only for this population. It reports 41%, not 10%, in sporadic cases; the paper does not establish these percentages for all Parkinson’s disease cases. (LLM, conf=0.90)
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Epidemiology and etiology of Parkinson's disease: a review of the evidence
Wirdefeldt, K., Adami, H.-O., Cole, P., Trichopoulos, D., & Mandel, J. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9581-6 · Cited by 1,199
Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance
Hernandez, D. G., Reed, X., & Singleton, A. B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13593 · Cited by 448
“…Jewish PD patients, and it is believed that most LRRK2 p.G2019S mutation carriers are from a common founder originating in North Africa and spreading with the Jewish diaspora (Brice 2005; Farrer et al. 2005; Kachergus et al. 2005; Lesage et al. 2006a,b; Ozelius et al. 2006; Healy et al. 2008).”
BackgroundInfluentialRamonet, D., Daher, J. P. L., Lin, B. M., Stafa, K., Kim, J., Banerjee, R., Westerlund, M., Pletnikova, O., Glauser, L., Yang, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018568 · Cited by 405
The Role of LRRK2 in Neurodegeneration of Parkinson Disease
Rui, Q., Ni, H., Li, D., Gao, R., & Chen, G. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180222165418 · Cited by 196
UDCA exerts beneficial effect on mitochondrial dysfunction in LRRK2 G2019S carriers and in vivo
Mortiboys, H., Furmston, R., Bronstad, G., Aasly, J., Elliott, C., & Bandmann, O. (2015) · Neurology · doi:10.1212/wnl.0000000000001905 · Cited by 131
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
Choi, I., Kim, B., Byun, J.-W., Baik, S. H., Huh, Y. H., Kim, J.-H., Mook-Jung, I., Song, W. K., Shin, J.-H., Seo, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9255 · Cited by 112
Wu, Y., Pei, Y., Yang, Z., Li, K., Lou, X., & Cui, W. (2020) · Aging · doi:10.18632/aging.103878 · Cited by 12
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Singh, V., Menard, M. A., Serrano, G. E., Beach, T. G., Zhao, H. T., Riley-DiPaolo, A., Subrahmanian, N., LaVoie, M. J., & Volpicelli-Daley, L. A. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01704-9 · Cited by 9
Metadata
- Authors
- Lesage, S., Dürr, A., Tazir, M., Lohmann, E., Leutenegger, A.-L., Janin, S., Pollak, P., & Brice, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-01-26
- Volume
- 354
- Issue
- 4
- Pages
- 422-423
- ISSN
- 0028-4793
- 1533-4406
- Cited by
- 494
- References
- 0
- Language
- en
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