LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

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Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts

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A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

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The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

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Inflammatory Responses Are Not Sufficient to Cause Delayed Neuronal Death in ATP-Induced Acute Brain Injury

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Mitoxantrone Targets the ATP-binding Site of FAK, Binds the FAK Kinase Domain and Decreases FAK, Pyk-2, c-Src, and IGF-1R In Vitro Kinase Activities

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Parkinson's Disease and Low Frequency Alleles Found Together Throughout LRRK2

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Microglia and astrocyte dysfunction in parkinson's disease

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Astrocytes, Microglia, and Parkinson’s Disease

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Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

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Microglia: Brain cells on the move

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Protective Microglia and Their Regulation in Parkinson’s Disease

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Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient‐derived induced pluripotent stem cells

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Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

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G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice

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Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease

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A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D2 synthase expression

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LRRK2 modulates microglial activity through regulation of chemokine (C–X3–C) receptor 1 –mediated signalling pathways

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The Involvement of Neuroinflammation in the Onset and Progression of Parkinson’s Disease

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A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

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LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

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Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy

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Targeting LRRK2 in Parkinson’s disease: an update on recent developments

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LRRK2 Gly2019Ser Mutation Promotes ER Stress via Interacting with THBS1/TGF‐β1 in Parkinson's Disease

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Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ 42 in triggering receptor expressed on myeloid cells 2 loss‐of‐function murine models

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LRRK2 as a target for modulating immune system responses

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Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model

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Genetic Imaging of Neuroinflammation in Parkinson’s Disease: Recent Advancements

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Mechanisms of Mutant LRRK2 Neurodegeneration

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A P arkinson's disease gene, DJ ‐1, repairs brain injury through S ox9 stabilization and astrogliosis

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Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology

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The role of LRRK2 in cytoskeletal dynamics

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Pivotal Role of Fyn Kinase in Parkinson’s Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target?

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Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration

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Integration of iPSC-Derived Microglia into Brain Organoids for Neurological Research

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Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission

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Leucine‐rich repeat kinase 2 and Parkinson's disease

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Parkinson disease–associatedLRRK2 G2019Stransgene disrupts marrow myelopoiesis and peripheral Th17 response

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Microglia: roles and genetic risk in Parkinson’s disease

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Interaction of LRRK2 and α-Synuclein in Parkinson’s Disease

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Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's disease

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Integrin-Kindlin3 requirements for microglial motility in vivo are distinct from those for macrophages

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Microglial cells: Sensors for neuronal activity and microbiota-derived molecules

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The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization

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Critical roles of astrocytic‐CCL2‐dependent monocyte infiltration in a DJ‐1 knockout mouse model of delayed brain repair

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LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway

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Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

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Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor α-mediated neurotoxicity

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Convergent mechanisms of microglia‐mediated synaptic dysfunction contribute to diverse neuropathological conditions

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Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors

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Morphological diversity of microglia: Implications for learning, environmental adaptation, ageing, sex differences and neuropathology

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Emerging roles of protein kinases in microglia-mediated neuroinflammation

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Leucine-Rich Repeat Kinase 2 Influences Fate Decision of Human Monocytes Differentiated from Induced Pluripotent Stem Cells

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An Aqueous Extract of Herbal Medicine ALWPs Enhances Cognitive Performance and Inhibits LPS-Induced Neuroinflammation via FAK/NF-κB Signaling Pathways

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Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice

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Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s diseasePreprint

Gaertner, Z. A., Oram, C., Schneeweis, A. K., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J.-F., & Awatramani, R. B. (2024) · eLife · doi:10.7554/elife.101035 · Cited by 20 · see citing works

Dissecting the non-neuronal cell contribution to Parkinson’s disease pathogenesis using induced pluripotent stem cells

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Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo

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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model

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How Parkinson’s Disease-Linked LRRK2 Mutations Affect Different CNS Cell Types

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The Double-Faceted Role of Leucine-Rich Repeat Kinase 2 in the Immunopathogenesis of Parkinson’s Disease

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LRRK2 and WAVE2 regulate microglial‐transition through distinct morphological phenotypes to induce neurotoxicity in a novel two‐hit in vitro model of neurodegeneration

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Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?

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The Parkinson's disease–associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages

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The efficient generation of knockout microglia cells using a dual-sgRNA strategy by CRISPR/Cas9

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Leucine-rich repeat kinase 2-related functions in GLIA: an update of the last years

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Quantitative Proteomic Analysis of Primitive Neural Stem Cells from LRRK2 G2019S-Associated Parkinson’s Disease Patient-Derived iPSCs

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Longitudinal dysregulation of long non-coding RNAs in Parkinson’s disease

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GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices

Zhou, G., & Zha, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.692217 · Cited by 8 · see citing works

Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors

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Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

Gaertner, Z. A., Oram, C., Schneeweis, A. K., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J.-F., & Awatramani, R. B. (2025) · eLife · doi:10.1101/2024.06.06.597807 · Cited by 8 · see citing works

Toward Systemic Lipofuscin Removal

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LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2

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The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells

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Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease

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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition

Kim, B., Suh, Y. H., & Joe, E.-H. (2022) · Animal Cells and Systems · doi:10.1080/19768354.2022.2158219 · Cited by 7 · see citing works

In silico discovery of novel compounds for FAK activation using virtual screening, AI-based prediction, and molecular dynamics

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Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models

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Deficiency of leucine-rich repeat kinase 2 aggravates thioacetamide-induced acute liver failure and hepatic encephalopathy in mice

Li, D., Yu, S.-F., Lin, L., Guo, J., Huang, S.-M., Wu, X., You, H.-L., Cheng, X., Zhang, Q., Zeng, Y., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03125-4 · Cited by 5 · see citing works

The Integrin Pathway Partially Mediates Stretch-Induced Deficits in Primary Rat Microglia

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The LRRK2-G2019S mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles

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Well-Tempered Metadynamics Simulations Combined with Free Energy Landscape Analysis Uncover the Conformational Transition Pathway of the DYG Motif in LRRK2

Gong, X., Tan, S., Wang, L., Tian, Y., Zhang, Q., Tong, H. H. Y., Yao, X., & Liu, H. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00054 · Cited by 4 · see citing works

Air-liquid interface culture of midbrain organoids improves neuronal functionality and integration of microgliaPreprint

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Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s diseasePreprint

Gaertner, Z. A., Oram, C., Schneeweis, A. K., Schonfeld, E., Bolduc, C., Chen, C., Dombeck, D. A., Parisiadou, L., Poulin, J. F., & Awatramani, R. B. (2024) · eLife · doi:10.7554/elife.101035.1 · Cited by 5 · see citing works

Therapeutic Targeting of Autosomal Parkinson’s Disease by Modulation of Leucine-Rich Repeat Kinase 2 (LRRK2) Protein

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Peripheral immunochemical considerations in Parkinson disease: sources, targets and crosstalk mechanisms

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Type I and II pili mediate Streptococcus pneumoniae invasion into human blood-brain barrier-derived cells through extracellular matrix protein receptors and different endocytosis pathways

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Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brainPreprint

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Quinpirole ameliorates the dysfunction of microglia in human LRRK2-R1441G transgenic micePreprint

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