The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Classic Twin Study of External Ear Malformations, Including Microtia
Open accessAbstract
To the Editor: The pathogenesis of microtia, a rare congenital malformation of the external ear, remains elusive. Phenotypes range from minor deformities, such as preauricular tags, to anotia, the ...
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The auricle's plasticity greatly reduces after 6 weeks due to decreased estrogen and hyaluronic acid content in the child's blood circulation.
“The auricle's plasticity greatly reduces after 6 weeks due to decreased estrogen and hyaluronic acid content in the child's blood circulation (9–11).”
From Using Ear Molding to Treat Congenital Auricular Deformities (2021) · cites this paper as [9]
The main text (page unavailable) reports twin concordance rates and discusses genetic and environmental contributions to external-ear malformations. Searches for auricular plasticity after six weeks, estrogen, and hyaluronic acid found no passage addressing the claimed change or its cause. (LLM, conf=0.78)
Experimental — accuracy not yet measuredEstrogen can increase the content of hyaluronic acid and thus the plasticity of auricular cartilage.
“Estrogen can increase the content of hyaluronic acid and thus the plasticity of auricular cartilage.”
From Using Ear Molding to Treat Congenital Auricular Deformities (2021) · cites this paper as [9]
The study’s main text reports twin concordance rates and genetic and environmental contributions to external-ear malformations (page not provided). Searches for estrogen, hyaluronic acid, and cartilage plasticity found no passage addressing the claimed mechanism. (LLM, conf=0.77)
Experimental — accuracy not yet measuredResidual maternal estrogen levels at birth peak within 72 h of birth and return to their baseline at 6 weeks.
“Residual maternal estrogen levels at birth peak within 72 h of birth and return to their baseline at 6 weeks.”
From Using Ear Molding to Treat Congenital Auricular Deformities (2021) · cites this paper as [9]
The paper’s main text (page unavailable) discusses twin concordance and genetic contributions to external-ear malformations, not maternal estrogen after birth. Searches for the claimed 72-hour peak and six-week return to baseline found no relevant passage in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThe optimal time for non-invasive correction of auricle deformities is 5-7 days after birth.
“The optimal time for non-invasive correction of auricle deformities is 5–7 days after birth.”
From Using Ear Molding to Treat Congenital Auricular Deformities (2021) · cites this paper as [9]
The main text (page unavailable) examines twin concordance and the genetic contribution to external-ear malformations, not their non-invasive correction. Searches for the claimed 5–7-day window and for newborn ear-molding timing found no passage addressing optimal treatment timing. (LLM, conf=0.76)
Experimental — accuracy not yet measured
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Citations
Cites
Genetics of microtia and associated syndromes
Alasti, F., & Camp, G. V. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.062158 · Cited by 166
Congenital heart defects in patients with oculo‐auriculo‐vertebral spectrum (Goldenhar syndrome)
Digilio, M. C., Calzolari, F., Capolino, R., Toscano, A., Sárközy, A., Zorzi, A. D., Dallapiccola, B., & Marino, B. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32407 · Cited by 66
Wieczorek, D., Ludwig, M. Z., Böehringer, S., Jongbloet, P. H., Gillessen‐Kaesbach, G., & Horsthemke, B. (2007) · Human Genetics · doi:10.1007/s00439-007-0336-0 · Cited by 61
Left microtia in one monozygotic twin. A case report.
Neal, G. S., & Hankins, G. D. V. (1992) · PubMed · Cited by 8
IPSILATERAL MICROTIA IN MONOZYGOTIC TWINS: AN UNUSUAL CONCORDANT PHENOTYPE
Hussain, M., Ball, E. A., & Moss, A. L. H. (2004) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000110861.47621.45 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 1
- Neal GS, 1992, J Reprod Med, 37, 375
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Sorted by citations
Nonsurgical Management of Congenital Auricular Anomalies
Lennon, C., & Chinnadurai, S. (2018) · Facial Plastic Surgery Clinics of North America · doi:10.1016/j.fsc.2017.09.001 · Cited by 28
Using Ear Molding to Treat Congenital Auricular Deformities
Chen, Y., Wang, W., Wang, Y., & Mao, X. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.752981 · Cited by 15
Metadata
- Authors
- Artunduaga, M. A., Quintanilla-Dieck, M. D. L., Greenway, S., Betensky, R., Nicolau, Y., Hamdan, U., Jarrin, P., Osorno, G., Brent, B., Eavey, R., Seidman, C., & Seidman, J. G.
- Affiliations
- Harvard University (US)
- University of California San Diego (US)
- Universidad Nacional de Colombia (CO)
- El Camino Hospital (US)
- Vanderbilt University (US)
- Howard Hughes Medical Institute (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-09-17
- Volume
- 361
- Issue
- 12
- Pages
- 1216-1218
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC3648865
- OpenAlex
- W2054454269
- Cited by
- 39
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (TL1TR000169, UL1TR000170, KL2TR000168)
- National Heart, Lung, and Blood Institute (PL1HL092552)
- National Institute on Deafness and Other Communication Disorders (R01DC007453)
- National Center for Research Resources (UL1RR025758, KL2RR025757, TL1RR025756)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Genetics (clinical) › Congenital Ear and Nasal Anomalies
- Health Sciences › Medicine › Surgery › Reconstructive Facial Surgery Techniques
- Health Sciences › Medicine › Surgery › Craniofacial Disorders and Treatments
- Keywords
- microtia, external ear malformation, twin studies, congenital malformations, pathogenesis, anotia, preauricular tags, heritability
- MeSH terms
- Congenital Abnormalities, Ear, External, Genotype, Humans, Mutation, Twins, Dizygotic, Twins, Monozygotic
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