Cited by 24Gastrointestinal Tumor Research and TreatmentNeuroendocrine Tumor Research AdvancesThyroid Disorders and Treatments

Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors

Sosipatros Alexandros Boikos, Lee J. Helman, Constantine A. Stratakis·2014·New England Journal of Medicine

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Crossref · 10.1056/nejmc1405198

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  • The ALBIOS trial in 1,818 patients with sepsis or septic shock found no difference between albumin plus crystalloids and crystalloids alone in 28-day or 90-day mortality.

    “The largest clinical trial in sepsis, the ALBIOS trial comparing a combination of albumin and crystalloids to crystalloids alone in 1818 patients with sepsis or septic shock did not demonstrate a difference in 28-day (RR 1.0; 95% CI 0.87–1.14) or 90-day mortality (RR 0.94; 95% CI 0.85–1.05) [339].”
  • Evidence shows higher blood pressure at early and later time points, higher static filling pressures, and lower net fluid balance with albumin.

    “The suggestion to consider albumin in patients who received large volumes of crystalloids is informed by evidence showing higher blood pressure at early and later time points [339], higher static filling pressures [340], and lower net fluid balance [339] with albumin.”
  • Albumin is theoretically more likely to maintain oncotic pressure than crystalloids.

    “Although albumin is theoretically more likely to maintain oncotic pressure than crystalloids [339]”

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Authors
Boikos, S. A., Helman, L. J., & Stratakis, C. A.
Venue
New England Journal of Medicine
Published
2014-07-03
Volume
371
Issue
1
Pages
84-87
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2406148105
Cited by
24
References
0
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 1
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords
thyroid hormone inactivation, gastrointestinal stromal tumor, tyrosine kinase inhibitors, drug resistance, tyrosine kinase inhibitor resistance
MeSH terms
Gastrointestinal Neoplasms, Humans, Hypothyroidism, Iodide Peroxidase, Male, Thyroid Hormones, Gastrointestinal Stromal Tumors

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