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Albumin Replacement in Severe Sepsis or Septic Shock
Abstract
To the Editor: The Albumin Italian Outcome Sepsis study conducted by Caironi et al. (April 10 issue)1 is the third large-scale, randomized trial to compare albumin with crystalloids in adult patients with severe sepsis. The first such trial was the Saline versus Albumin Fluid Evaluation study.2 In addition, the Early Albumin Resuscitation during Septic Shock study has been completed and its mortality results published.3 In all three trials, mortality was lower among patients receiving albumin, and the respective relative risks coincided closely, ranging from 0.87 to 0.94 (Fig. 1). Although the effect did not attain statistical significance in any of the individual trials, the pooled relative risk in all three trials is 0.92 (95% confidence interval [CI], 0.84 to 1.00; P = 0.046), indicating a significant reduction in mortality associated with albumin use among adults with severe sepsis. This result supports the conclusion of a previous metaanalysis involving predominantly small trials with different control fluids and patient populations.4 The result is also consistent with the observed reduction in mortality associated with albumin use among patients with spontaneous bacterial peritonitis, a disease that shares important pathophysiological features with severe sepsis.5
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Smaller studies suggest that source control within 6 to 12 hours is advantageous.
“While there are limited data to conclusively issue a recommendation regarding the timeframe in which source control should be obtained, smaller studies suggest that source control within 6 to 12 hours is advantageous (265-271).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [266]
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Albumin Replacement in Patients with Severe Sepsis or Septic Shock
Caironi, P., Tognoni, G., Masson, S., Fumagalli, R., Pesenti, A. M., Romero, M., Fanizza, C., Caspani, L., Faenza, S., Grasselli, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305727 · Cited by 1,314
Self-citationNitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238
Quinlan, G. J., Martin, G. S., & Evans, T. W. (2005) · Hepatology · doi:10.1002/hep.20720 · Cited by 985
Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis
The SAFE Study Investigators (2010) · Intensive Care Medicine · doi:10.1007/s00134-010-2039-6 · Cited by 404
Delaney, A. P., Dan, A., McCaffrey, J., & Finfer, S. R. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181ffe217 · Cited by 342
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2
O'Brien, A. J., Fullerton, J. N., Massey, K. A., Auld, G., Sewell, G. W., Naomi-James, S., Newson, J., Karra, E., Winstanley, A. M., Alazawi, W., et al. (2014) · Nature Medicine · doi:10.1038/nm.3516 · Cited by 286
Salerno, F., Navickis, R. J., & Wilkes, M. M. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.007 · Cited by 220
Quinlan, G. J., Margarson, M., Mumby, S. E., Evans, T. W., & Gutteridge, J. M. C. (1998) · Clinical Science · doi:10.1042/cs0950459 · Cited by 160
Quinlan, G. J., MARGARSON, M. P., Mumby, S. E., et al. (1998) · Clinical Science · doi:10.1042/cs19980191 · Cited by 62
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Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
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Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
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Irvine, K. M., Ratnasekera, I. U., Powell, E. E., & Hume, D. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00293 · Cited by 181
Fluid management in sepsis: The potential beneficial effects of albumin
Vincent, J., Backer, D. D., & Wiedermann, C. J. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.04.019 · Cited by 149
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Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis
Hong, W., Lin, S., Zippi, M., Geng, W., Stock, S., Basharat, Z., Cheng, B., Pan, J., & Zhou, M. (2017) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2017/5297143 · Cited by 122
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Albumin in critically ill patients
Caironi, P., Länger, T., & Gattinoni, L. (2015) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000223 · Cited by 66
Self-citationSemler, M. W., & Rice, T. W. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.007 · Cited by 63
Development and validation of a risk prediction score for severe acute pancreatitis
Hong, W., Lillemoe, K. D., Pan, S., Zimmer, V., Kontopantelis, E., Stock, S., Zippi, M., Wang, C., & Zhou, M. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1903-6 · Cited by 56
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Melia, D., & Post, B. (2020) · Journal of the Intensive Care Society · doi:10.1177/1751143720961245 · Cited by 54
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Englert, F. A., Seidel, R. A., Galler, K., Gouveia, Z. L., Soares, M. P., Neugebauer, U., Clemens, M. G., Sponholz, C., Heinemann, S. H., Pohnert, G., et al. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108075 · Cited by 32
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Metadata
- Authors
- Caironi, P., Tognoni, G., & Gattinoni, L.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-07-03
- Volume
- 371
- Issue
- 1
- Pages
- 83-84
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1230640476
- Cited by
- 80
- References
- 8
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 3
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- albumin, sepsis, septic shock, crystalloids, fluid resuscitation, mortality, spontaneous bacterial peritonitis
- MeSH terms
- Albumins, Female, Humans, Isotonic Solutions, Male, Shock, Septic, Rehydration Solutions, Sepsis
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