The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Heparin-Induced Thrombocytopenia Presenting as Bilateral Adrenal Hemorrhages
Open accessAbstract
Drug Administration in 2005 as a topical 5% gel (50 mg of dapsone per 1 g of product; Aczone, Allergan).After the topical application of dapsone gel, a plasma level is detectable within 2 hours and has a half-life of 48 hours. 2 Our patient had been applying a pea-sized amount of topical dapsone twice daily for 7 days before presentation.Details of the mechanism of dapsone-induced methemoglobinemia and a discussion of other possible contributing factors in this patient's case are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.Our case report highlights the potential for systemic absorption with clinical methemoglobinemia after prescribed therapeutic use of a topical dapsone-containing product.
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“heparin (thrombocytopenia-mediated adrenal hemorrhage) (48).”
From The Changing Face of Drug-induced Adrenal Insufficiency in the Food and Drug Administration Adverse Event Reporting System (2022) · cites this paper as [48]
Citations
Cites
Temporal Aspects of Heparin-Induced Thrombocytopenia
Warkentin, T. E., & Kelton, J. G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104263441704 · Cited by 977
Self-citationDelayed-Onset Heparin-Induced Thrombocytopenia and Thrombosis
Warkentin, T. E., & Kelton, J. G. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-135-7-200110020-00009 · Cited by 463
Self-citationA Comparison of Danaparoid and Lepirudin in Heparin-induced Thrombocytopenia
Farner, B., Eichler, P., Kroll, H., & Greinacher, A. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615946 · Cited by 192
Warkentin, T. E., Basciano, P. A., Knopman, J., & Bernstein, R. A. (2014) · Blood · doi:10.1182/blood-2014-01-549741 · Cited by 159
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Sorted by citations
Autoimmune heparin‐induced thrombocytopenia
Greinacher, A., Selleng, K., & Warkentin, T. E. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13813 · Cited by 414
Self-citationHeparin-Induced Thrombocytopenia
Greinacher, A., Bakchoul, T., Cuker, A., & Warkentin, T. E. (1997) · Elsevier eBooks · doi:10.1002/9781118520093.ch30 · Cited by 194
Self-citationHeparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management
Hogan, M., & Berger, J. S. (2020) · Vascular Medicine · doi:10.1177/1358863x19898253 · Cited by 183
Li, X., Gao, P., Tan, J., Xiong, K., Maitz, M. F., Pan, C., Wu, H., Chen, Y., Yang, Z., & Huang, N. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b14409 · Cited by 172
Heparin-Induced Thrombocytopenia
Arepally, G. M., & Padmanabhan, A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315445 · Cited by 159
Metadata
- Authors
- Warkentin, T. E., Safyan, E. L., & Linkins, L.-A.
- Affiliations
- McMaster University (CA)
- University of Pittsburgh Medical Center (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-01-29
- Volume
- 372
- Issue
- 5
- Pages
- 492-494
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2020248408
- Cited by
- 57
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 6
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Health Sciences › Medicine › Hematology › Methemoglobinemia and Tumor Lysis Syndrome
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- heparin-induced thrombocytopenia, bilateral adrenal hemorrhage, dapsone, methemoglobinemia, systemic absorption, adverse drug reactions
- MeSH terms
- Adrenal Gland Diseases, Anticoagulants, Hemorrhage, Heparin, Humans, Thrombocytopenia
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- CoChat. (2026). Citation check: Heparin-Induced Thrombocytopenia Presenting as Bilateral Adrenal Hemorrhages. https://app.cochat.ai/papers/10.1056/nejmc1414161
- The paper
- Warkentin, T. E., Safyan, E. L., & Linkins, L.-A. (2015). Heparin-Induced Thrombocytopenia Presenting as Bilateral Adrenal Hemorrhages. New England Journal of Medicine. https://doi.org/10.1056/nejmc1414161
