Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

Rosenberg, S. A., Yang, J. C., Sherry, R. M., Kammula, U. S., Hughes, M. S., Phan, G. Q., Citrin, D. E., Restifo, N. P., Robbins, P. F., Wunderlich, J. R., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0116 · Cited by 2,145 · see citing works

Pancreatic Cancer

Park, W., Chawla, A., & O'Reilly, E. M. (2021) · JAMA · doi:10.1001/jama.2021.13027 · Cited by 1,931 · see citing works

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

Tran, E., Turcotte, S., Gros, A., Robbins, P. F., Lu, Y., Dudley, M. E., Wunderlich, J. R., Somerville, R. P. T., Hogan, K., Hinrichs, C. S., et al. (2014) · Science · doi:10.1126/science.1251102 · Cited by 1,710 · see citing works

Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer

Leidner, R. S., Silva, N. S., Huang, H., Sprott, D. E., Zheng, C., Shih, Y.-P., Leung, A., Payne, R., Sutcliffe, K., Cramer, J., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2119662 · Cited by 527 · see citing works

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

Di Pilato, M., Kfuri-Rubens, R., Pruessmann, J. N., Ozga, A. J., Messemaker, M., Cadilha, B. L., Sivakumar, R., Cianciaruso, C., Warner, R. D., Marangoni, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.015 · Cited by 488 · see citing works

A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers

Stevanović, S., Helman, S. R., Wunderlich, J., Langhan, M. M., Doran, S., Kwong, M.-L. M., Somerville, R., Klebanoff, C., Kammula, U., Sherry, R., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2722 · Cited by 250 · see citing works

Breast Cancers Are Immunogenic: Immunologic Analyses and a Phase II Pilot Clinical Trial Using Mutation-Reactive Autologous Lymphocytes

Zacharakis, N., Huq, L., Seitter, S. J., Kim, S. P., Gartner, J. J., Sindiri, S., Hill, V. K., Li, Y. F., Paria, B. C., Ray, S., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.21.02170 · Cited by 196 · see citing works

T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00737-6 · Cited by 183 · see citing works

CXCR6 by increasing retention of memory CD8 + T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer

Muthuswamy, R., McGray, A. R., Battaglia, S., He, W., Miliotto, A. J., Eppolito, C., Matsuzaki, J., Tsuji, T., Koya, R. C., Chodon, T., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003329 · Cited by 70 · see citing works

Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study

Krüger, S., Lohneis, A., Abendroth, A., Berger, A. W., Ettrich, T. J., Waidmann, O., Kapp, M., Steiner, B., Kumbrink, J., Reischer, A., et al. (2022) · ESMO Open · doi:10.1016/j.esmoop.2022.100388 · Cited by 22 · see citing works

Unveiling the role of KRAS in tumor immune microenvironment

Xu, M., Zhao, X., Wen, T., & Qu, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116058 · Cited by 93 · see citing works

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

Sivakumar, S., Jainarayanan, A., Arbe-Barnes, E. H., Sharma, P. K., Leathlobhair, M. N., Amin, S., Reiss, D. J., Heij, L. R., Hegde, S., Magen, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55424-2 · Cited by 67 · see citing works

Improving outcomes of patients with pancreatic cancer

Dreyer, S. B., Beer, P. A., Hingorani, S. R., & Biankin, A. V. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01019-9 · Cited by 66 · see citing works

Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment

Baharom, F., Hermans, D., Delamarre, L., & Seder, R. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01091-9 · Cited by 47 · see citing works

Challenges and solutions for therapeutic TCR ‐based agents

Malviya, M., Aretz, Z. E. H., Molvi, Z., Lee, J., Pierre, S. A., Wallisch, P., Dao, T., & Scheinberg, D. A. (2023) · Immunological Reviews · doi:10.1111/imr.13233 · Cited by 37 · see citing works

Pancreatic ductal adenocarcinoma (PDAC): clinical progress in the last five years

Mosalem, O. M., Abdelhakeem, A. A. F., Abdel-Razeq, N. H., & Babiker, H. M. (2025) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2025.2473698 · Cited by 30 · see citing works

Driving neoantigen-based cancer vaccines for personalized immunotherapy into clinic: A burdensome journey to promising land

Yu, G., He, X., Li, X., & Wu, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113464 · Cited by 20 · see citing works

Immunotherapy in the Fight Against Bone Metastases: A Review of Recent Developments and Challenges

Peng, Z., Huang, W. P., Xiao, Z., Wang, J., Zhu, Y., Zhang, F., Lan, D., & He, F. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01256-7 · Cited by 14 · see citing works

KRAS, a New Target for Precision Medicine in Colorectal Cancer?

Boilève, A., Smolenschi, C., Lambert, A., Boige, V., Delaye, M., Camilleri, G. M., Tarabay, A., Valéry, M., Fuerea, A., Pudlarz, T., et al. (2024) · Cancers · doi:10.3390/cancers16203455 · Cited by 11 · see citing works

Design of nano-delivery systems for pancreatic cancer immunotherapy

Fu, S., Gao, C., Yu, Q., Gong, R., Yang, Z., Zang, X., Shan, S., Mombrú, D., Romero, M., Mombrú, Á. W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218098 · Cited by 11 · see citing works

Characterizing and forecasting neoantigens-resulting from MUC mutations in COAD

Chen, M., Zhang, X., Ming, Z., Lingyu, Feng, X., Han, Z., & An, H. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05103-z · Cited by 11 · see citing works

Nanomaterial-assisted pancreatic cancer theranostics

Liu, Y., Xu, H., Bai, S., Chen, T., Ma, X., Lin, J., Sun, L., Gao, C., Wu, A., & Li, Q. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbaf054 · Cited by 8 · see citing works

CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus

Yang, J., Song, Y., Xu, S., Ge, S., & Haiwen, Z. (2023) · Organogenesis · doi:10.1080/15476278.2023.2234504 · Cited by 4 · see citing works

Improving molecular subtypes and prognosis of pancreatic cancer through multi group analysis and machine learning

Zhang, X., Lin, F.-F., Wen, Y.-Q., & Guan, K.-P. (2025) · Discover Oncology · doi:10.1007/s12672-025-01841-8 · Cited by 3 · see citing works

Facilitating Personalized Immunotherapy with Interventional Radiology and Tumor Organoids

Tian, W., McKenney, A. S., & Zhan, C. (2025) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2025.08.038 · Cited by 2 · see citing works

IL-12 and GM-CSF engineered dendritic cells enhance the enrichment and selection of tumor-reactive T cells for cancer immunotherapy

Liu, Z., Li, H., Gao, Z., Cheng, R., Lu, J., Che, X., Dong, J., Wang, Z., Cui, Z., Gu, J., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1684842 · Cited by 1 · see citing works

Progress in cell-based immunotherapies for solid tumors

Zhang, L., Zhang, D., & Wang, B. (2026) · Discover Oncology · doi:10.1007/s12672-026-05092-z · Cited by 1 · see citing works

Uncovering ectopic GC-like niches for tumor reactive lymphocyte priming in lung adenocarcinoma using Stereo-XCR-seq

Zhan, X., Huang, M., Zhang, Y., Liu, Z., Liu, C., Guo, Y., Liu, Y., Zhou, W., Yan, Y., Zeng, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75405-x · Cited by 1 · see citing works

Metastasiertes nichtkleinzelliges Lungenkarzinom: Zielgerichtete Therapie – was uns in der Zukunft erwartet

Christopoulos, P. (2023) · Deutsches Ärzteblatt · doi:10.3238/personko.2023.03.03.02

Progress in understanding of relationship between intestinal microecology and pancreatic cancer

Qin, Y.-M., & Sha, J. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i24.1001

Editorial: Drug development for pancreatic cancer: novel targets, drug candidates and mechanisms

Sun, X., & Xu, H. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1705678

Mapping the frontiers: a bibliometric perspective on t cell-based immunotherapy in pancreatic cancer since the twenty-first century

Tang, Z., Wang, C., Ma, Z., Shang, P., Yuan, Q., & Yue, J. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06356-x

Multidisciplinary treatment incorporating autologous DC-CIK cell therapy induces long-term survival in advanced pancreatic cancer: a case report

Chen, S., Xie, Y., Xu, S., Su, L., Xu, Y., Liu, S., Zheng, Q., Liu, Q., & Sun, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1908017

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177P Ubiquitous neoantigens as targets for T cell recognition in a patient with metastatic pancreatic neuroendocrine tumour

Tanis, J., McCann, K. J., Castaneda, E., Thomas, J., Bailey, A. G., Pickering, J., Singh, P., Tiwari, A., Currall, E., Chudley, L., et al. (2024) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2024.100930

Neoantigen-Based Immunotherapy for a Long-Term Survivor With Pancreatic Neuroendocrine Tumor

Tang, X., Shao, Y., Li, D., & Ding, K. (2022) · Pancreas · doi:10.1097/mpa.0000000000002092

Genetic therapy for pancreatic neoplasms

Leng, Y. (2000) · Cited by 6 · see citing works