Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas

Papke, David J.; Yurgelun, Matthew B.; Noffsinger, Amy E.; Turner, Kevin O.; Genta, Robert M.; Redston, Mark

doi:10.1056/nejmc2210175

Cited by 72Genetic factors in colorectal cancerColorectal Cancer Surgical TreatmentsDNA Repair Mechanisms

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Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas

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Papke, David J., Yurgelun, Matthew B., Noffsinger, Amy E., Turner, Kevin O., Genta, Robert M., Redston, Mark·2022·New England Journal of Medicine

DOI 10.1056/nejmc2210175

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Depending on disease stage, only around 3-15% of CRCs classify as dMMR/MSI-H, whereas the remaining ones are pMMR/MSS.
“However, depending on disease stage, only around 3–15% of CRCs classify as dMMR/MSI-H, whereas the remaining ones are pMMR/MSS.9”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [9]

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938 High Prevalence of Mismatch Repair Deficiency Among Colorectal Cancers Diagnosed After Colonoscopy
Stoffel, E. M., Erichsen, R., Frøslev, T., Vyberg, M., Koeppe, E. S., Hamilton, S. R., Baron, J. A., & Sørensen, H. T. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)60580-1
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Mismatch Repair Deficiency in Sporadic Colorectal Cancers
任舒月, 陈春生, & 任常山 (1998)
Gender difference for mismatch repair deficiency in human colorectal cancer
Duval, A., Iacopetta, B. J., Thorstensen, L., Meling, G. I., Lothe, R. A., Thuille, B., Suraweera, N., Thomas, G. D., & Hamelin, R. (2001) · Gastroenterology · doi:10.1053/gast.2001.28585 · Cited by 14

Authors: Papke, D. J., Yurgelun, M. B., Noffsinger, A. E., Turner, K. O., Genta, R. M., & Redston, M.
Affiliations: Brigham and Women's Hospital (US)
Dana-Farber Cancer Institute (US)
Inform Diagnostics, Irving, TX
ORCID: Papke, David J.
Yurgelun, Matthew B.
Turner, Kevin O.
Genta, Robert M.
Redston, Mark
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2022-11-03
Volume: 387
Issue: 18
Pages: 1714-1716
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmc2210175
OpenAlex: W4308146090
Cited by: 72
References: 5
Citations by year: 2026: 14 · 2025: 20 · 2024: 23 · 2023: 14 · 2022: 1
FWCI: 9.82
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: mismatch repair deficiency, rectal adenocarcinoma, Lynch syndrome, hereditary colorectal cancer, DNA mismatch repair, cancer prevalence
MeSH terms: Adenocarcinoma, Brain Neoplasms, Humans, Neoplastic Syndromes, Hereditary, Colorectal Neoplasms, Prevalence, DNA Mismatch Repair

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Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas

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