The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hemoglobin and the Paracrine and Endocrine Functions of Nitric Oxide
Abstract
Nitric oxide, a key factor in the maintenance of vascular tone, causes vascular smooth muscles to relax. Hemoglobin rapidly destroys nitric oxide, thereby limiting the activity of the gas to the local environment. Recent work suggests that nitric oxide reacts with hemoglobin at high oxygen tensions to form relatively long-lived products. At low oxygen tensions, these products release vasodilatory nitric oxide. This work is controversial, but it provides evidence of the potential of inhaled nitric oxide as a therapeutic agent.
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Citations
Cites
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
Reiter, C. D., Wang, X., Tanus-Santos, J. E., Hogg, N., Cannon, R. O., Schechter, A. N., & Gladwin, M. T. (2002) · Nature Medicine · doi:10.1038/nm1202-799 · Cited by 1,330
Self-citationGladwin, M. T., Wang, X., Reiter, C. D., Yang, B. K., Vivas, E. X., Bonaventura, C., & Schechter, A. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203236200 · Cited by 160
Self-citation
Cited by
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Self-citationEndothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Self-citationStrategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
Self-citationYudkin, J. S., Eringa, E., & Stehouwer, C. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66585-3 · Cited by 549
Metadata
- Authors
- Schechter, A. N., & Gladwin, M. T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-04-10
- Volume
- 348
- Issue
- 15
- Pages
- 1483-1485
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2072877187
- Cited by
- 251
- References
- 2
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schechter, A. N., & Gladwin, M. T. (2003). Hemoglobin and the Paracrine and Endocrine Functions of Nitric Oxide. New England Journal of Medicine. https://doi.org/10.1056/nejmcibr023045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
