Endothelial Function and Dysfunction: Testing and Clinical Relevance

Deanfield, John E.; Halcox, Julian P.; Rabelink, Ton J.

doi:10.1161/circulationaha.106.652859

Cited by 2,710Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionCardiovascular Disease and Adiposity

Endothelial Function and Dysfunction: Testing and Clinical Relevance

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Deanfield, John E., Halcox, Julian P., Rabelink, Ton J.·2007·Circulation

DOI 10.1161/circulationaha.106.652859

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A dysfunctional endothelium produces less vasodilators in response to the same amount of shear stress, resulting in less vasodilation.
“However, a dysfunctional endothelium produces less vasodilators in response to the same amount of shear stress, resulting in less vasodilation (35–37).”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [36]

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Mechanisms of Diabetic Complications
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
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Cigarette Smoking and Hypertension
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Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease
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Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
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MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1
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Endothelial Dysfunction in Chronic Inflammatory Diseases
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Methodological issues in the assessment of skin microvascular endothelial function in humans
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Nonalcoholic Fatty Liver Disease and the Heart
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Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation
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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice
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Dietary Phosphorus Acutely Impairs Endothelial Function
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Alexander, M. Y., Osto, E., Schmidt‐Trucksäss, A., Shechter, M., Trifunović, D., Duncker, D. J., Aboyans, V., Bäck, M., Badimón, L., Cosentino, F., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa085 · Cited by 401 · see citing works
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Importance of Measuring the Time Course of Flow-Mediated Dilatation in Humans
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Mediterranean diet and health status: Active ingredients and pharmacological mechanisms
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Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects
Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 384 · see citing works
Alcohol's Effects on the Cardiovascular System.
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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works
Health-promoting effects of the citrus flavanone hesperidin
Li, C., & Schluesener, H. J. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.906382 · Cited by 357 · see citing works
eNOS, metabolic syndrome and cardiovascular disease
Huang, P. L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.03.005 · Cited by 357 · see citing works
Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip
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Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction
Xu, J., & Zou, M. (2009) · Circulation · doi:10.1161/circulationaha.108.835223 · Cited by 348 · see citing works
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction
Severino, P., D’Amato, A., Pucci, M., Infusino, F., Adamo, F., Birtolo, L. I., Netti, L., Montefusco, G., Chimenti, C., Lavalle, C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218118 · Cited by 362 · see citing works
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
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Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches
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Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults
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Assessment and Treatment of Cardiovascular Risk in Prediabetes: Impaired Glucose Tolerance and Impaired Fasting Glucose
DeFronzo, R. A., & Abdul‐Ghani, M. A. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.03.013 · Cited by 318 · see citing works
Endothelial Function Predicts Progression of Carotid Intima-Media Thickness
Halcox, J., Donald, A. E., Ellins, E. A., Witte, D. R., Shipley, M. J., Brunner, E. J., Marmot, M. G., & Deanfield, J. E. (2009) · Circulation · doi:10.1161/circulationaha.108.765701 · Cited by 315 · see citing works
Pathophysiology of Cardiovascular Diseases: New Insights into Molecular Mechanisms of Atherosclerosis, Arterial Hypertension, and Coronary Artery Disease
Frąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081938 · Cited by 339 · see citing works
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Pernow, J., & Jung, C. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt036 · Cited by 311 · see citing works
Blood pressure rise following angiogenesis inhibition by bevacizumab. A crucial role for microcirculation
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Endothelial Function in Human Immunodeficiency Virus-Infected Antiretroviral-Naive Subjects Before and After Starting Potent Antiretroviral Therapy
Torriani, F. J., Komarow, L., Parker, R. A., Cotter, B. R., Currier, J. S., Dubé, M. P., Fichtenbaum, C. J., Gerschenson, M., Mitchell, C. K. C., Murphy, R. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.04.049 · Cited by 300 · see citing works
The role of low-grade inflammation in the polycystic ovary syndrome
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Impaired nitric oxide bioavailability and l -arginine–reversible endothelial dysfunction in adults with falciparum malaria
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Non-Invasive Vascular Function Tests:
Tomiyama, H., & Yamashina, A. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0534 · Cited by 298 · see citing works
Psoriasis and metabolic disease: epidemiology and pathophysiology
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Systemic and Pulmonary Vascular Dysfunction in Children Conceived by Assisted Reproductive Technologies
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Significance of a Multiple Biomarkers Strategy Including Endothelial Dysfunction to Improve Risk Stratification for Cardiovascular Events in Patients at High Risk for Coronary Heart Disease
Nozaki, T., Sugiyama, S., Koga, H., Sugamura, K., Ohba, K., Matsuzawa, Y., Sumida, H., Matsui, K., Jinnouchi, H., & Ogawa, H. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.022 · Cited by 294 · see citing works
Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study
Velmurugan, S., Gan, J. M., Rathod, K. S., Khambata, R. S., Ghosh, S. M., Hartley, A., Van Eijl, S., Sagi-Kiss, V., Chowdhury, T. A., Curtis, M., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116244 · Cited by 284 · see citing works
Assessment of atherosclerosis: the role of flow-mediated dilatation
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Authors: Deanfield, J. E., Halcox, J. P., & Rabelink, T. J.
Affiliations: Leiden University Medical Center (NL)
ORCID: Deanfield, John E.
Halcox, Julian P.
Rabelink, Ton J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-03-13
Volume: 115
Issue: 10
Pages: 1285-1295
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.106.652859
OpenAlex: W1849785625
Cited by: 2,710
References: 106
Citations by year: 2026: 81 · 2025: 95 · 2024: 124 · 2023: 131 · 2022: 157 · 2021: 154 · 2020: 142 · 2019: 128 · 2018: 160 · 2017: 171 · 2016: 167 · 2015: 168 · 2014: 189 · 2013: 134 · 2012: 146
FWCI: 14.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: endothelial function, endothelial dysfunction, endothelium, vascular function
MeSH terms: Animals, Endothelium, Vascular, Homeostasis, Humans, Risk Factors, Vasodilation, Signal Transduction, Biomarkers, Disease Progression, Atherosclerosis

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