The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Expression of Concern Reaffirmed
Abstract
On December 8, 2005, we published an expression of concern1 regarding an article by Bombardier et al. on the Vioxx Gastrointestinal Outcomes Research (VIGOR) study that was published in the Journal on November 23, 2000.2 Our expression of concern was prompted by evidence that the VIGOR article did not accurately represent the safety data available to the authors when the article was being reviewed for publication. More than four months before the article was published, at least two of its authors were aware of critical data on an array of adverse cardiovascular events that were not included in the VIGOR . . .
Overview
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Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“How harms outcomes are assessed will affect the results obtained.276 277 278 279”
From SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials (2025) · cites this paper as [278]
Citations
Cites
Bombardier, C., Laine, L., Reicin, A. S., Shapiro, D., Burgos‐Vargas, R., Davis, B. R., Day, R. O., Ferraz, M. B., Hawkey, C. J., Hochberg, M. C., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011233432103 · Cited by 4,014
Ombardier, C. L. B., Aine, L. O. L., Eicin, A. L. R., Hapiro, D. E. S., Urgos, R. U. B., Avis, B. A. D., Ay, R., Arcos, M. J., Erraz, B. O. F., Awkey, C. H. J. H., et al. (2010) · Cited by 252
Curfman, G., Morrissey, S., & Drazen, J. M. (2005) · New England Journal of Medicine · doi:10.1056/nejme058314 · Cited by 157
Self-citationResponse to Expression of Concern Regarding VIGOR Study
Bombardier, C., Laine, L., Burgos‐Vargas, R., Davis, B. R., Day, R. O., Ferraz, M. B., Hawkey, C. J., Hochberg, M. C., Kvien, T. K., Schnitzer, T. J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmc066096 · Cited by 29
Research works printed but not linked: 2
- Reicin A, 2006, N Engl J Med, 354, 1198
- 10.1056/NEJMe058314 · DOI
Cited by
Sorted by citations
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis
Trelle, S., Reichenbach, S., Wandel, S., Hildebrand, P., Tschannen, B., Villiger, P. M., Egger, M., & Jüni, P. (2011) · BMJ · doi:10.1136/bmj.c7086 · Cited by 1,196
Dissemination and publication of research findings: an updated review of related biases
Song, F., Parekh, Hooper, L., Loke, Y., Ryder, J., Sutton, A., Hing, C., Kwok, C., Pang, C., & Harvey, I. (2010) · Health Technology Assessment · doi:10.3310/hta14080 · Cited by 1,039
Ford, A. C., Talley, N. J., Spiegel, B. M. R., Foxx-Orenstein, A. E., Schiller, L., Quigley, E. M. M., & Moayyedi, P. (2008) · BMJ · doi:10.1136/bmj.a2313 · Cited by 565
Publication Bias in the Organizational Sciences
Kepes, S., Banks, G. C., McDaniel, M. A., & Whetzel, D. L. (2012) · Organizational Research Methods · doi:10.1177/1094428112452760 · Cited by 416
Metadata
- Authors
- Curfman, G. D., Morrissey, S., & Drazen, J. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-03-16
- Volume
- 354
- Issue
- 11
- Pages
- 1193-1193
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1998613929
- Cited by
- 109
- References
- 4
- Citations by year
- 2025: 14 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 6
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Nursing › Issues, ethics and legal aspects › Pharmaceutical industry and healthcare
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- rofecoxib, VIGOR trial, cardiovascular adverse events, drug safety, publication integrity, expression of concern
- MeSH terms
- Arthritis, Rheumatoid, Cardiovascular Diseases, Gastrointestinal Diseases, Humans, Lactones, Myocardial Infarction, Naproxen, Research Design, Sulfones, Thromboembolism
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