The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Metabolic Enzymes as Oncogenes or Tumor Suppressors
Open accessAbstract
Whether mutations in metabolic pathways contribute to the pathogenesis of cancer is controversial.1,2 Cancer cells have long been noted to preferentially metabolize glucose through glycolysis, a discovery that has been translated to the clinic through positron-emission-tomography imaging of 18F-deoxyglucose uptake in tumors. Moreover, recent studies have uncovered recurrent somatic mutations in four genes involved in the metabolism of mitochondrial citrate that either cause or predispose cells to become malignant.In this issue of the Journal, Yan and colleagues3 report that 70% or more of low-grade gliomas bear mutations in one of two NADP+-dependent isocitrate dehydrogenase enzymes (IDH1 and . . .
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“Recently it has become apparent that cancer is also associated with metabolic mutations confined to the tumor. In these diseases, the metabolic enzymes behave genetically as oncogenes or tumor suppressors (Figure 3A) (Frezza et al., 2011a; Thompson, 2009).”
From Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? (2012) · cites this paper as Thompson, 2009
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Cites
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Self-citationAnalysis of the IDH1 codon 132 mutation in brain tumors
Balss, J., Meyer, J., Mueller, W., Korshunov, A., Hartmann, C., & von Deimling, A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0455-2 · Cited by 1,036
Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer
King, A., Selak, M. A., & Gottlieb, E. (2006) · Oncogene · doi:10.1038/sj.onc.1209594 · Cited by 672
Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E., & Ding, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404298200 · Cited by 407
MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359
Gasparre, G., Porcelli, A. M., Bonora, E., Pennisi, L. F., Toller, M., Iommarini, L., Ghelli, A. M., Moretti, M., Betts, C. M., Martinelli, G. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703056104 · Cited by 316
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
Hartong, D. T., Dange, M., McGee, T. L., Berson, E. L., Dryja, T. P., & Colman, R. F. (2008) · Nature Genetics · doi:10.1038/ng.223 · Cited by 172
Lee, J. K., Edderkaoui, M., Truong, P. A., Ohno, I., Jang, K., Berti, A., Pandol, S. J., & Gukovskaya, A. S. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.022 · Cited by 157
Kil, I. S., Kim, S. Y., Lee, S. J., & Park, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.07.009 · Cited by 51
Regulation of replicative senescence by NADP+-dependent isocitrate dehydrogenase
Kil, I. S., Huh, T. L., Lee, Y. S., Lee, Y. M., & Park, J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.021 · Cited by 44
Research works printed but not linked: 1
- 10.1056/NEJMoa0808710 · DOI · Paper page
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Sorted by citations
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Self-citationAerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404
Cancer metabolism: looking forward
Martínez‐Reyes, I., & Chandel, N. S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00378-6 · Cited by 1,877
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120
Metadata
- Authors
- Thompson, C. B.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Thompson, Craig B.
- ORCID
- Thompson, Craig B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-02-19
- Volume
- 360
- Issue
- 8
- Pages
- 813-815
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC2848669
- OpenAlex
- W2075033593
- Cited by
- 213
- References
- 12
- Citations by year
- 2026: 2 · 2024: 12 · 2023: 4 · 2022: 15 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01CA104838, R01CA092660, R01CA105463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- metabolic enzymes, oncogenes, tumor suppressor, isocitrate dehydrogenase, IDH1, IDH2, low-grade glioma, somatic mutations, cancer metabolism, glycolysis
- MeSH terms
- Brain Neoplasms, DNA Mutational Analysis, Fumarate Hydratase, Glioblastoma, Glioma, Humans, Isocitrate Dehydrogenase, Mutation, Succinate Dehydrogenase, Hypoxia-Inducible Factor 1
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