Cited by 215Cancer, Hypoxia, and MetabolismGlioma Diagnosis and TreatmentCancer, Lipids, and Metabolism

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Metabolic Enzymes as Oncogenes or Tumor Suppressors

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Thompson, Craig B.·2009·New England Journal of Medicine

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Abstract

Whether mutations in metabolic pathways contribute to the pathogenesis of cancer is controversial.1,2 Cancer cells have long been noted to preferentially metabolize glucose through glycolysis, a discovery that has been translated to the clinic through positron-emission-tomography imaging of 18F-deoxyglucose uptake in tumors. Moreover, recent studies have uncovered recurrent somatic mutations in four genes involved in the metabolism of mitochondrial citrate that either cause or predispose cells to become malignant.In this issue of the Journal, Yan and colleagues3 report that 70% or more of low-grade gliomas bear mutations in one of two NADP+-dependent isocitrate dehydrogenase enzymes (IDH1 and . . .

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Authors: Thompson, C. B.
Affiliations: University of Pennsylvania (US)
Corresponding author: Thompson, Craig B.
ORCID: Thompson, Craig B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2009-02-19
Volume: 360
Issue: 8
Pages: 813-815
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejme0810213
PMC: PMC2848669
OpenAlex: W2075033593
Cited by: 213
References: 12
Citations by year: 2026: 2 · 2024: 12 · 2023: 4 · 2022: 15 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P01CA104838, R01CA092660, R01CA105463)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: metabolic enzymes, oncogenes, tumor suppressor, isocitrate dehydrogenase, IDH1, IDH2, low-grade glioma, somatic mutations, cancer metabolism, glycolysis
MeSH terms: Brain Neoplasms, DNA Mutational Analysis, Fumarate Hydratase, Glioblastoma, Glioma, Humans, Isocitrate Dehydrogenase, Mutation, Succinate Dehydrogenase, Hypoxia-Inducible Factor 1

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